benzamidomethyl 4-(benzamidomethoxy)phenyl ether

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzamidomethyl 4-(benzamidomethoxy)phenyl ether
• 英文别名: N-[[4-(benzamidomethoxy)phenoxy]methyl]benzamide
• 化学式: C₂₂H₂₀N₂O₄
• 分子量: 376.412
• InChiKey: KWWZMUGCFURGEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (benzamidomethyl)triethylammonium chloride 在 TEA 作用下， 以 水 、 丙酮 为溶剂， 生成 benzamidomethyl 4-(benzamidomethoxy)phenyl ether
  参考文献：
  名称：

  Simple Method for Benzamidomethylation of Phenols in Water Solution

  摘要：

  Benzamidomethyl ethers ROCH(2)NHBz (5) (R = aryl, cyclohexyl and benzyl) were obtained in high yields in reactions of ROH (4) with (benzamidomethyl)triethylammonium chloride 3 as a benzamidomethylation agent. Reactions occurred in water, except reactions of cyclohexyl and benzyl alcohol with 3 that occurred in CHCl3.

  DOI：

  10.1080/00397919908085975

文献信息

• Simple Method for Benzamidomethylation of Phenols in Water Solution
  作者：Emil Popovski、Ljiljana Klisarova、Dražen Vikič-Topić

  DOI：10.1080/00397919908085975

  日期：1999.10

  Benzamidomethyl ethers ROCH(2)NHBz (5) (R = aryl, cyclohexyl and benzyl) were obtained in high yields in reactions of ROH (4) with (benzamidomethyl)triethylammonium chloride 3 as a benzamidomethylation agent. Reactions occurred in water, except reactions of cyclohexyl and benzyl alcohol with 3 that occurred in CHCl3.