H-Dap(1)-N(Me)Leu-Sar-N(Me)Leu-(2).H-Dap(2)-N(Me)Leu-Sar-N(Me)Leu-(1) | 1031272-66-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Dap(1)-N(Me)Leu-Sar-N(Me)Leu-(2).H-Dap(2)-N(Me)Leu-Sar-N(Me)Leu-(1)
• 英文别名: (3S,9S,12S,16S,22S,25S)-12,25-diamino-4,7,10,17,20,23-hexamethyl-3,9,16,22-tetrakis(2-methylpropyl)-1,4,7,10,14,17,20,23-octazacyclohexacosane-2,5,8,11,15,18,21,24-octone
• CAS: 1031272-66-8
• 化学式: C₄₀H₇₄N₁₀O₈
• 分子量: 823.09
• InChiKey: CPYSTVBTQBTZPH-JNRWAQIZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  58
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  232
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  H-Dap(1)-N(Me)Leu-Sar-N(Me)Leu-(2).H-Dap(2)-N(Me)Leu-Sar-N(Me)Leu-(1) 生成 Fmoc-Dap(1)-N(Me)Leu-Sar-N(Me)Leu-(2).Fmoc-Dap(2)-N(Me)Leu-Sar-N(Me)Leu-(1)
  参考文献：
  名称：

  Design and Synthesis of FAJANU: a de Novo C₂ Symmetric Cyclopeptide Family

  摘要：

  A novel cyclic peptide has been designed from several potent marine cytotoxic peptides, including IB-01212, luzopeptin, triostin, and thiocoraline. The FAJANU scaffold maintains C-2 symmetry, cyclic structure, and the construction of aromatic and aliphatic character at the N- and C-terminal extremes. A first six-member family was previously synthesized and evaluated biologically. Several analogues presented greater activity than IB-01212. Furthermore, on the basis of the most active candidate, we have performed a more exhaustive synthetic and structural analysis: (i) structure-activity relationship provided clues about the key elements in the framework, (ii) NMR assignment confirmed C-2, symmetry, and (iii) confocal images revealed its penetration and cellular localization.

  DOI：

  10.1021/jm800047b
• 作为产物：
  描述：

  di-tert-butyl ((2S,8S,12S,15S,21S,25S)-2,8,15,21-tetraisobutyl-1,4,7,14,17,20-hexamethyl-3,6,9,13,16,19,22,26-octaoxo-1,4,7,10,14,17,20,23-octaazacyclohexacosane-12,25-diyl)dicarbamate 在 三异丙基硅烷 、 水 、 三氟乙酸 作用下， 生成 H-Dap(1)-N(Me)Leu-Sar-N(Me)Leu-(2).H-Dap(2)-N(Me)Leu-Sar-N(Me)Leu-(1)
  参考文献：
  名称：

  Design and Synthesis of FAJANU: a de Novo C₂ Symmetric Cyclopeptide Family

  摘要：

  A novel cyclic peptide has been designed from several potent marine cytotoxic peptides, including IB-01212, luzopeptin, triostin, and thiocoraline. The FAJANU scaffold maintains C-2 symmetry, cyclic structure, and the construction of aromatic and aliphatic character at the N- and C-terminal extremes. A first six-member family was previously synthesized and evaluated biologically. Several analogues presented greater activity than IB-01212. Furthermore, on the basis of the most active candidate, we have performed a more exhaustive synthetic and structural analysis: (i) structure-activity relationship provided clues about the key elements in the framework, (ii) NMR assignment confirmed C-2, symmetry, and (iii) confocal images revealed its penetration and cellular localization.

  DOI：

  10.1021/jm800047b

文献信息

• Design and Synthesis of FAJANU: a de Novo <i>C</i>₂ Symmetric Cyclopeptide Family
  作者：Fayna Garcia-Martin、Luis J. Cruz、Ricard A. Rodriguez-Mias、Ernest Giralt、Fernando Albericio

  DOI：10.1021/jm800047b

  日期：2008.6.1

  A novel cyclic peptide has been designed from several potent marine cytotoxic peptides, including IB-01212, luzopeptin, triostin, and thiocoraline. The FAJANU scaffold maintains C-2 symmetry, cyclic structure, and the construction of aromatic and aliphatic character at the N- and C-terminal extremes. A first six-member family was previously synthesized and evaluated biologically. Several analogues presented greater activity than IB-01212. Furthermore, on the basis of the most active candidate, we have performed a more exhaustive synthetic and structural analysis: (i) structure-activity relationship provided clues about the key elements in the framework, (ii) NMR assignment confirmed C-2, symmetry, and (iii) confocal images revealed its penetration and cellular localization.