2-(3-(4-hydroxyphenyl)propyl)benzene-1,3,5-triol | 127265-09-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-(3-(4-hydroxyphenyl)propyl)benzene-1,3,5-triol
• 英文别名: (p-hydroxyphenylpropyl)phloroglucinol；2-[3-(4-hydroxy-phenyl)-propyl]-phloroglucinol；3-(4-Hydroxy-phenyl)-1-(2.4.6-trihydroxy-phenyl)-propan；2-[3-(4-Hydroxy-phenyl)-propyl]-phloroglucin；2-[3-(4-hydroxyphenyl)propyl]benzene-1,3,5-triol
• CAS: 127265-09-2
• 化学式: C₁₅H₁₆O₄
• 分子量: 260.29
• InChiKey: QTRGEOYAVGDPSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 amalgamated zinc 作用下， 生成 2-(3-(4-hydroxyphenyl)propyl)benzene-1,3,5-triol
  参考文献：
  名称：

  Yield and Quality of Leek in Response to Compost Applied as a Mulch or Incorporated Into the Soil

  摘要：

  DOI：

  10.1080/1065657x.2002.10702086

文献信息

• Substrate‐Controlled Hydrogenation of Flavanones: Selective Synthesis of 2′‐Hydroxy‐1,3‐Diarylpropanes and Flavans
  作者：Martín Soto、Paula Pérez‐Ramos、Raquel G. Soengas、Humberto Rodríguez‐Solla

  DOI：10.1002/ejoc.202300139

  日期：——

  Herein, a new substrate-controlled hydrogenation of flavanones to selectively obtain 2′-hydroxy-1,3-diarylpropanes or flavans depending on the substitution of the flavanone moiety is described. Thus, hydrogenation of non-fluorinated flavanones provided the corresponding 2′-hydroxy-1,3-diarylpropanes, whereas hydrogenation of fluorinated flavanones afforded selectively the corresponding flavans in excellent

  在此，描述了一种新的底物控制的黄烷酮氢化，根据黄烷酮部分的取代选择性地获得 2'-羟基-1,3-二芳基丙烷或黄烷。因此，非氟化黄烷酮的氢化提供了相应的 2'-羟基-1,3-二芳基丙烷，而氟化黄烷酮的氢化以优异的产率选择性地提供了相应的黄烷。
• Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors
  作者：Amol Gupte、John K. Buolamwini

  DOI：10.1016/j.bmcl.2008.11.112

  日期：2009.2

  Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio-protective and neuroprotective agents. Although quite a few potent inhibitors of the equilibrative nucleoside transporters are known, largely missing are the concentrative nucleoside transporter inhibitors. Phloridzin (3, K-i = 16.00 mu M) is a known moderate inhibitor of the concentrative nucleoside transporters. We have synthesized and evaluated analogs of phloridzin at the hCNT3 nucleoside transporter. Within the series of synthesized analogs compound 16 (K-i = 2.88 mu M), possessing a ribofuranose sugar unit instead of a glucopyranose as present in phloridzin, exhibited the highest binding affinity at the hCNT3 transporter. Phloridzin and compound 16 have also been shown to be selective for the hCNT3 transporter as compared with the hENT1 transporter. Compound 16 can serve as a new lead which after further modi. cations could yield selective and potent hCNT3 inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.
• Funatsu, Takakazu; Iriye, Ryozo; Takai, Hideyuki, Agricultural and Biological Chemistry, 1989, vol. 53, # 11, p. 3087 - 3090
  作者：Funatsu, Takakazu、Iriye, Ryozo、Takai, Hideyuki、Hirota, Mitsuru

  DOI：——

  日期：——
• FUNATSU, TAKAKAZU;IRIYE, RYOZO;TAKAI, HIDEYUKI;HIROTA, MITSURU, AGR. AND BIOL. CHEM., 53,(1989) N1, C. 3087-3089
  作者：FUNATSU, TAKAKAZU、IRIYE, RYOZO、TAKAI, HIDEYUKI、HIROTA, MITSURU

  DOI：——

  日期：——
• [EN] TASTE MODIFIERS<br/>[FR] MODIFICATEURS DE GOÛT
  申请人：PEPPER SEVEN UP INC DR

  公开号：WO2013074811A1

  公开（公告）日：2013-05-23

  A beverage or other composition may include phloretin and trilobatin wherein the weight ratio of phloretin to trilobatin is from about 1 : 1 to about 3: 1. The concentration of phloretin in such a composition may be about 5 ppm to about 150 ppm. The combination of phloretin and trilobatin may remove one or more negative characteristics of the composition.