N-allyl-3-(4-ethylphenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine | 1421637-32-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-allyl-3-(4-ethylphenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine
• 英文别名: 3-(4-ethylphenyl)-N-prop-2-enyl-[1,3]thiazolo[4,5-c]pyridazin-6-amine
• CAS: 1421637-32-2
• 化学式: C₁₆H₁₆N₄S
• 分子量: 296.396
• InChiKey: ZTTNKPRURUTBJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  78.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-乙基苯硼酸 在 四(三苯基膦)钯 、 碳酸氢钠 、 sodium carbonate 、 caesium carbonate 作用下， 以 甲醇 、 水 、 甲苯 、 乙腈 为溶剂， 反应 30.5h， 生成 N-allyl-3-(4-ethylphenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine
  参考文献：
  名称：

  A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines

  摘要：

  A facile and efficient synthesis of 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines is reported. The key step for the construction of this novel bicyclic scaffold was the reaction between 3-amino-4-bromopyridazine derivatives and alkylisothiocyanates. The application of this methodology for the synthesis of a small library of thiazolo[4,5-c]pyridazines is also described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.072

文献信息

• A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines
  作者：Alessandro Stella、Steven De Jonghe、Kenneth Segers、Piet Herdewijn

  DOI：10.1016/j.tetlet.2012.11.072

  日期：2013.2

  A facile and efficient synthesis of 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines is reported. The key step for the construction of this novel bicyclic scaffold was the reaction between 3-amino-4-bromopyridazine derivatives and alkylisothiocyanates. The application of this methodology for the synthesis of a small library of thiazolo[4,5-c]pyridazines is also described. (C) 2012 Elsevier Ltd. All rights reserved.