N²,N⁶-dilauroyl-DL-lysine | 17047-87-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N²,N⁶-dilauroyl-DL-lysine
• 英文别名: N²,N⁶-Dilauroyl-DL-lysin；N2,N6-Bis(1-oxododecyl)-L-lysine；2,6-bis(dodecanoylamino)hexanoic acid
• CAS: 17047-87-9
• 化学式: C₃₀H₅₈N₂O₄
• 分子量: 510.802
• InChiKey: ZQGOIDUGPJSGNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  36
• 可旋转键数：
  27
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  月桂酰氯 、 DL-赖氨酸 在 sodium hydroxide 作用下， 生成 N²,N⁶-dilauroyl-DL-lysine
  参考文献：
  名称：

  The Preparation of Long Chain N-Acylamino Acids

  摘要：

  DOI：

  10.1021/ja01582a049

文献信息

• CATIONIC LIPIDS, METHODS FOR PREPARING THE SAME, AND DELIVERY SYSTEMS HAVING ABILITY TO TRANSITION INTO CELLS COMPRISING THE SAME
  申请人：Park Myung-Ok

  公开号：US20130123485A1

  公开（公告）日：2013-05-16

  The present invention provides cationic lipids, methods for preparing the same, and delivery systems comprising the same. The present invention can provide cationic lipids which enhance the efficiency of intracellular or in vivo delivery of multiple-anionic target compounds such as drugs, anticancer agents, nucleic acids, etc., have no intracellular toxicity, but show increased stability, methods for preparing the same, and delivery systems comprising the same.

  本发明提供了阳离子脂质、其制备方法以及包含该脂质的传递系统。本发明可以提供增强多阴离子靶向化合物（如药物、抗癌剂、核酸等）在细胞内或体内传递效率的阳离子脂质，不具有细胞内毒性，但表现出增加的稳定性，以及其制备方法和包含该脂质的传递系统。
• Isothiocyanate functional surfactants, formulations incorporating isothiocyanate functional surfactants and associated methods for treating biofilms
  申请人：Silver Michael E.

  公开号：US10273205B2

  公开（公告）日：2019-04-30

  The present invention relates to methods, formulations, and compositions for the treatment of biofilms. In particular, the application discloses isothiocyanate functional surfactants either alone or combination with adjunct agents to treat biofilms. One suitable isothiocyanate functional surfactant is represented by the following chemical structure:

  本发明涉及治疗生物膜的方法、制剂和组合物。特别是，本申请公开了异硫氰酸盐功能表面活性剂，可以单独使用，也可以与辅助剂结合使用，以治疗生物膜。一种合适的异硫氰酸酯功能表面活性剂由以下化学结构表示：
• ISOTHIOCYANATE FUNCTIONAL SURFACTANTS, FORMULATIONS INCORPORATING ISOTHIOCYANATE FUNCTIONAL SURFACTANTS AND ASSOCIATED METHODS FOR TREATING BIOFILMS
  申请人：Silver Michael E.

  公开号：US20180037545A1

  公开（公告）日：2018-02-08

  The present invention relates to methods, formulations, and compositions for the treatment of biofilms. In particular, the application discloses isothiocyanate functional surfactants either alone or combination with adjunct agents to treat biofilms. One suitable isothiocyanate functional surfactant is represented by the following chemical structure:
• The Preparation of Long Chain N-Acylamino Acids
  作者：E. Jungermann、J. F. Gerecht、I. J. Krems

  DOI：10.1021/ja01582a049

  日期：1956.1