(7-bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one)dichloroplatinum(II) | 113602-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (7-bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one)dichloroplatinum(II)
• 英文别名: 7-Bromo-5-pyridin-2-yl-1,3-dihydro-1,4-benzodiazepin-2-one;dichloroplatinum
• CAS: 113602-36-1
• 化学式: C₁₄H₁₀BrCl₂N₃OPt
• 分子量: 582.143
• InChiKey: QRWXXNJZYFQFNZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  4.01
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  cis-dichlorobis(dimethylsulfoxide)platinum(II) 、 溴西泮 以 二氯甲烷 为溶剂， 生成 (7-bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one)dichloroplatinum(II)
  参考文献：
  名称：

  Metal complexes of benzodiazepines. Kinetic properties of bromazepam toward square planar dimethyl sulfoxide complexes of platinum(II) and palladium(II)

  摘要：

  The kinetics of substitution reactions of Me(2)SO from the complexes [MX(2)(Me(2)SO)(2)] (M=Pt, X=Cl CH3, cis; M=Pd, X=Cl, trans) by the ligands bromazepam or bipy have been investigated in Me(2)SO and/or CH2Cl2 at 25 degrees C. The results are interpreted in terms of an associative mechanism for cis-[PtCl2(Me(2)SO)(2)] and a dissociative mechanism for cis-[PtMe(2)(Me(2)SO)(2)]. The substitution reaction for the complex trans-[PdCl2(Me(2)SO)(2)] proceeds without retention of stereochemistry; a consecutive displacement mechanism or a pseudo-rotation mechanism can be operative. The kinetic behaviour of bromazepam and bipy is very similar.

  DOI：

  10.1016/0020-1693(93)03654-s

文献信息

• Metal complexes of benzodiazepines. Part 3. Synthesis and characterization of organometallic complexes of platinum(II)
  作者：Maria C. Aversa、Paola Bonaccorsi、Matteo Cusumano、Placido Giannetto、Domenico Minniti

  DOI：10.1039/dt9910003431

  日期：——

  The complexes cis-[PtMe2(Me2SO)L1] and [PtR2L2] (R = Me or Ph) are easily obtained by reaction in CH2Cl2 of the complexes [PtMe2(Me2SO)2] or [PtPh2(Et2S)}2] with L1 = 2,3-dihydro-2,2,4-trimethyl-1H-1,5-benzodiazepine or L2 = bromazepam = 7-bromo-1,3-dihydro-5-(2-pyridyl)2-H-1,4-benzodiazepin-2-one. They are the first examples of simple organometallic adducts of benzodiazepines with platinum(II). Their H-1 and C-13 NMR spectra suggest the co-ordination of L1 through N5, while L2 acts as a bidentate ligand by means of the imine and pyridine nitrogen atoms. The co-ordinated heterocyclic rings show a notable increase in their inversion barrier.