5-(3-Isoxazolyl)-3-thiophenesulfonyl chloride | 881381-15-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(3-Isoxazolyl)-3-thiophenesulfonyl chloride
• 英文别名: 5-(1,2-oxazol-3-yl)thiophene-3-sulfonyl chloride
• CAS: 881381-15-3
• 化学式: C₇H₄ClNO₃S₂
• 分子量: 249.7
• InChiKey: JDQZCZGPMQWZFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-phenyl-3-(4-piperidinyl)-1H-indole-7-carboxamide 、 5-(3-Isoxazolyl)-3-thiophenesulfonyl chloride 、 三乙胺 生成 3-(1-{[5-(3-isoxazolyl)-3-thienyl]sulfonyl}-4-piperidinyl)-5-phenyl-1H-indole-7-carboxamide
  参考文献：
  名称：

  Chemical Compounds

  摘要：

  本发明涉及新型吲哚羧酰胺衍生物。具体而言，本发明涉及公式I所示的化合物：其中R1，R2，R3，U和V如下所定义，及其药学上可接受的盐。本发明的化合物是IKK2的抑制剂，可用于治疗与不适当的IKK2（也称为IKKβ）活性有关的疾病，如类风湿性关节炎、哮喘和COPD（慢性阻塞性肺疾病）。因此，本发明还涉及包含本发明化合物的药物组合物。本发明还进一步涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制IKK2活性和治疗与此相关的疾病的方法。

  公开号：

  US20070254873A1

文献信息

• Chemical compounds
  申请人：Glaxo Group Limited

  公开号：US07858796B2

  公开（公告）日：2010-12-28

  The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

  本发明涉及新型吲哚羧酰胺衍生物。具体而言，本发明涉及公式I所示的化合物，其中R1、R2、R3、U和V的定义如下，以及其药学上可接受的盐。本发明的化合物是IKK2的抑制剂，可用于治疗与不适当IKK2（也称为IKKβ）活性相关的疾病，如类风湿性关节炎、哮喘和COPD（慢性阻塞性肺疾病）。因此，本发明还涉及包含该化合物的制药组合物。本发明还进一步涉及使用该化合物或包含该化合物的制药组合物来抑制IKK2活性和治疗与之相关的疾病的方法。
• CHEMICAL COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1793826A2

  公开（公告）日：2007-06-13
• US7858796B2
  申请人：——

  公开号：US7858796B2

  公开（公告）日：2010-12-28
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：GLAXO GROUP LTD

  公开号：WO2006034317A2

  公开（公告）日：2006-03-30

  The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (1): where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKß) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.