6-(4-(N,N-dimethylamino)phenyl)-4-(4-methoxyphenyl)pyrimidin-2(1H)-one | 912960-76-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(4-(N,N-dimethylamino)phenyl)-4-(4-methoxyphenyl)pyrimidin-2(1H)-one
• 英文别名: 6-[4-(dimethylamino)phenyl]-4-(4-methoxyphenyl)-1H-pyrimidin-2-one
• CAS: 912960-76-0
• 化学式: C₁₉H₁₉N₃O₂
• 分子量: 321.379
• InChiKey: YHFKUXXNBDXQMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  53.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对二甲氨基苯甲醛 、 尿素 、 对甲氧基苯乙酮 在 sodium 作用下， 以 四氢呋喃 为溶剂， 反应 0.17h， 以90%的产率得到6-(4-(N,N-dimethylamino)phenyl)-4-(4-methoxyphenyl)pyrimidin-2(1H)-one
  参考文献：
  名称：

  A one-pot three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using atomized sodium in THF under sonic condition

  摘要：

  A simple and an efficient procedure for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones using atomized sodium/THF via a one-pot three-component Biginelli-like cyclocondensation of an aldehyde, a methyl ketone and urea under ultrasonic condition is developed. The method is mild and inexpensive; yields are high and the reactions go to completion within 10-15 min. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ultsonch.2013.12.021

文献信息

• TCT (2,4,6-Trichloro-1,3,5-triazine) Promoted Single-Step Syntheis of 4,6-Diarylpyrimidin-2(1H)-ones under Microwave Irradiation
  作者：Ahmad Reza Khosropour、Ahmad R. Khosropour、Iraj Mohammadpoor-Baltork、Mohammad M. Khodaei、Mahbubeh Jokar

  DOI：10.3987/com-05-10613

  日期：——
• A one-pot three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using atomized sodium in THF under sonic condition
  作者：Mohamed Afzal Pasha、Shrivatsa Nagashree

  DOI：10.1016/j.ultsonch.2013.12.021

  日期：2014.7

  A simple and an efficient procedure for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones using atomized sodium/THF via a one-pot three-component Biginelli-like cyclocondensation of an aldehyde, a methyl ketone and urea under ultrasonic condition is developed. The method is mild and inexpensive; yields are high and the reactions go to completion within 10-15 min. (C) 2013 Elsevier B.V. All rights reserved.