N-formyl-N-methylglycine | 38456-66-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-formyl-N-methylglycine
• 英文别名: N-formylsarcosine；N-formyl-sarcosine；N-Formylsarkosin；NFormylsarcosin；2-[formyl(methyl)amino]acetic acid
• CAS: 38456-66-5
• 化学式: C₄H₇NO₃
• 分子量: 117.104
• InChiKey: CGENPBMSAIVDAP-UHFFFAOYSA-N

物化性质

• 沸点：
  354.8±25.0 °C(Predicted)
• 密度：
  1.248±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-formyl-N-methylglycine 、 丙炔酸乙酯 以 乙酸酐 为溶剂， 以to obtain 18.08 g (yield 88.4%) of the title compound的产率得到乙基1-甲基吡咯-3-羧酸酯
  参考文献：
  名称：

  Process for preparing 1-substituted pyrrole-3-carboxylic acid derivatives

  摘要：

  提供了一种简单且工业上可行的制备1-取代吡咯-3-羧酸衍生物(I)的过程。该过程包括根据以下反应，将式(II)化合物、式(III)化合物和酸酐反应：##STR1## 其中R.sub.1和R.sub.2分别表示烷基、芳基烷基或芳基基团。

  公开号：

  US05684161A1

文献信息

• Pyrroloazepine derivatives
  申请人：Suntory Limited

  公开号：US05962448A1

  公开（公告）日：1999-10-05

  A pyrroloazepine compound having the following formula (I): wherein the ring P represented by ##STR1## is a pyrrole ring having the following structure: ##STR2## wherein R.sub.1 represents C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.4 -C.sub.8 cycloalkyl-alkyl, C.sub.6 -C.sub.14 aryl or C.sub.7 -C.sub.22 aralkyl, which are optionally substituted; and R.sub.2 represents H or C.sub.1 -C.sub.8 alkyl, which is optionally substituted; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z.sub.2 is not present and Z.sub.1 represents H, but, when the bond is absent, Z.sub.1 and Z.sub.2 are both H; Z.sub.1 represents H and Z.sub.2 represents a group OR.sub.3, in which R.sub.3 represents H, C.sub.1 -C.sub.8 alkyl, or C.sub.7 -C.sub.22 aralkyl, which are optionally substituted; Z.sub.1 and Z.sub.2 both represent groups SR.sub.4, in which R.sub.4 represents C.sub.1 -C.sub.8 alkyl or C.sub.7 -C.sub.22 aralkyl, which are optionally substituted; or Z.sub.1 and Z.sub.2 are combined together to represent O, a group NOR.sub.5, in which R.sub.5 represents H, or C.sub.1 -C.sub.8 alkyl or C.sub.2 -C.sub.3 alkylenedithio, which are optionally substituted; A represents alkylene, alkenylene or alkynylene; and Y represents a group in which W is CH, C.dbd. or N, m is for 0 or 1, n is for 1, 2 or 3, G is O, S, C.dbd.O, sulfinyl, sulfonyl, alkylene, alkenylene or acetal; E.sub.1 and E.sub.2 is H or C.sub.1 -C.sub.8 alkyl; and D represents an aromatic hydrocarbon or an aromatic heterocyclic ring. The compound (I) has strong serotonin-2 receptor antagonistic action and low toxicity and less side effects, and is therapeutically useful in the treatment of circulatory diseases and/or conditions related thereto.

  一种具有以下式（I）的吡咯环辛烷化合物：其中由##STR1##表示的环P是具有以下结构的吡咯环：##STR2##其中R.sub.1表示C.sub.1 -C.sub.8烷基，C.sub.3 -C.sub.8环烷基，C.sub.4 -C.sub.8环烷基-烷基，C.sub.6 -C.sub.14芳基或C.sub.7 -C.sub.22芳基烷基，可以选择性地取代；而R.sub.2表示H或C.sub.1 -C.sub.8烷基，可以选择性地取代；虚线表示键的存在或不存在；当键存在时，Z.sub.2不存在，Z.sub.1表示H，但当键不存在时，Z.sub.1和Z.sub.2都是H；Z.sub.1表示H，Z.sub.2表示OR.sub.3基团，其中R.sub.3表示H，C.sub.1 -C.sub.8烷基或C.sub.7 -C.sub.22芳基烷基，可以选择性地取代；Z.sub.1和Z.sub.2都表示SR.sub.4基团，其中R.sub.4表示C.sub.1 -C.sub.8烷基或C.sub.7 -C.sub.22芳基烷基，可以选择性地取代；或Z.sub.1和Z.sub.2结合在一起表示O，NOR.sub.5基团，其中R.sub.5表示H，或C.sub.1 -C.sub.8烷基或C.sub.2 -C.sub.3烷基二硫，可以选择性地取代；A表示烷基，烯烃基或炔烃基；Y表示一个基团，其中W为CH，C.dbd.或N，m为0或1，n为1，2或3，G为O，S，C.dbd.O，亚砜，砜基，烷基，烯烃基或缩醛基；E.sub.1和E.sub.2为H或C.sub.1 -C.sub.8烷基；D表示芳香烃或芳香杂环。化合物（I）具有强烈的5-羟色胺2受体拮抗作用，毒性低，副作用少，在治疗循环系统疾病和/或相关疾病方面具有治疗用途。
• Organosilicon based synthesis of new functionalized aminomethylenediphosphonates with moieties of amino acids
  作者：Andrey A. Prishchenko、Roman S. Alekseyev、Mikhail V. Livantsov、Olga P. Novikova、Ludmila I. Livantsova、Valery S. Petrosyan

  DOI：10.1016/j.jorganchem.2018.07.007

  日期：2018.9

  with moieties of various amino acids are synthesized via unique reaction of tris(trimethylsilyl) phosphite and N-formyl amino acids at the presence of effective catalyst – trimethylsilyl triflate under mild conditions. The further treatment of aminomethylenediphosphonates with the methanol excess resulted in the water-soluble functionalized aminomethylenediphosphonic acids.

  在有效的催化剂存在下，在温和的条件下，通过三（三甲基甲硅烷基）亚磷酸酯与N-甲酰基氨基酸的独特反应，合成了具有各种氨基酸部分的新型功能化氨基亚甲基二膦酸酯。用过量的甲醇进一步处理氨基亚甲基二膦酸酯，得到了水溶性官能化的氨基亚甲基二膦酸。
• Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents
  申请人：American Cyanamid Company

  公开号：US05284863A1

  公开（公告）日：1994-02-08

  Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole compounds which are effective for the phytopathogenic fungi are described. A method for the fungicidal use of said compounds and methods for the preparation of said compounds are presented.

  描述了对植物病原真菌有效的卤代硫、亚砜和磺酰基芳基吡咯烷化合物。提供了使用这些化合物的杀菌方法以及制备这些化合物的方法。
• Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and
  申请人：American Cyanamid Company

  公开号：US05306827A1

  公开（公告）日：1994-04-26

  Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole compounds which are effective for the control of insects and acarids are described. A method for the insecticidal and acaricidal use of said compounds and methods for the preparation of said compounds are presented.

  描述了对昆虫和螨虫有效的卤代硫基、-亚砜基和-砜基芳基吡咯烷化合物。提供了利用这些化合物进行杀虫和杀螨的方法，以及制备这些化合物的方法。
• Intermittent claudication therapeutic drugs comprising pyrroloazepines
  申请人：Suntory Limited

  公开号：US06288056B1

  公开（公告）日：2001-09-11

  A method of treating or improving intermittent claudication, which comprises administering, to a patient with intermittent claudication, a pyrroloazepine derivative or a pharmacologically acceptable salt thereof, said pyrroloazepine derivative being represented by the following formula (I): wherein the dotted line indicates existence or nonexistence of a bond; when the bond of the dotted line exists, X does not exist, and, when the bond of the dotted line does not exist, X represents a hydrogen atom, a hydroxy group or a group OR1 in which R1 represents a substituted or unsubstituted alkyl group; Y represents a linear or branched, substituted or unsubstituted alkyl group; Z1 and Z2 are the same or different and each independently represent a hydrogen atom, a hydroxy group or a halogen atom; and W represents a hydrogen atom or a methyl group.

  一种治疗或改善间歇性跛行的方法，包括向患有间歇性跛行的患者施用吡咯环庚烯衍生物或其药理学上可接受的盐，所述吡咯环庚烯衍生物由以下式（I）表示：其中虚线表示键的存在或不存在；当虚线的键存在时，X不存在，当虚线的键不存在时，X代表氢原子、羟基或其中R1代表取代或未取代的烷基的基团OR1；Y代表线性或支链、取代或未取代的烷基；Z1和Z2相同或不同，各自独立地表示氢原子、羟基或卤原子；W表示氢原子或甲基基团。