3-bromo-1-ethylpyrazole-4-carboxylic acid | 1399664-50-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-bromo-1-ethylpyrazole-4-carboxylic acid
• 英文别名: 3-Bromo-1-ethyl-1H-pyrazole-4-carboxylic acid
• CAS: 1399664-50-6
• 化学式: C₆H₇BrN₂O₂
• 分子量: 219.038
• InChiKey: DPOYHWHHYUDBTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] HETEROCYCLIC CARBOXYLATE COMPOUNDS AS GLYCOLATE OXIDASE INHIBITORS<br/>[FR] CARBOXYLATES HÉTÉROCYCLES EN TANT QU'INHIBITEURS DE GLYCOLATE OXYDASE
  申请人：GYANRX SCIENCES INC

  公开号：WO2021086874A1

  公开（公告）日：2021-05-06

  The present disclosure relates generally to modulators of human glycolate oxidase enzyme and methods of use and manufacture thereof. (I)

  本公开涉及人类乙醇酸氧化酶酶的调节剂及其使用和制造方法。
• [EN] BENZODIAZEPINE DERIVATIVES FOR TREATING A RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION<br/>[FR] DÉRIVÉS DE BENZODIAZÉPINE POUR LE TRAITEMENT D'UNE INFECTION PAR LE VIRUS RESPIRATOIRE SYNCYTIAL (RSV)
  申请人：REVIRAL LTD

  公开号：WO2021079121A1

  公开（公告）日：2021-04-29

  Benzodiazepine derivatives of formula (I): wherein: each of R1 and R2 is independently H or halo; R3 is H, C1-C6 alkyl, -NHR8 or -OR'; either (i) a, c, and e are all bonds, with b, d and f absent; or b, d and f are all bonds, with a, c and e absent; R4 is H or a group selected from C1-C6 alkyl, C3-C6 cycloalkyl and 4- to 10-membered heterocyclyl, the group being unsubstituted or substituted; R5 is H or halo; R6 is -OR8, -NR8R9 or -R8; R7 is H or halo; each of R8 and R9 is independently H or a group selected from C1-C6 alkyl, C3-C6 cycloalkyl and 4- to 10-membered heterocyclyl, the group being unsubstituted or substituted; R' is H or C1-C6 alkyl; and one of V and W is CH and the other is N or CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

  苯二氮卓啉衍生物的结构式（I）：其中：R1和R2中的每一个独立地是H或卤素；R3是H，C1-C6烷基，-NHR8或-OR'；要么（i）a，c和e都是键，b，d和f不存在；要么b，d和f都是键，a，c和e不存在；R4是H或从C1-C6烷基，C3-C6环烷基和4-到10-成员杂环基中选择的基团，该基团未取代或取代；R5是H或卤素；R6是-OR8，-NR8R9或-R8；R7是H或卤素；R8和R9中的每一个独立地是H或从C1-C6烷基，C3-C6环烷基和4-到10-成员杂环基中选择的基团，该基团未取代或取代；R'是H或C1-C6烷基；V和W中的一个是CH，另一个是N或CH；以及其药用盐是RSV的抑制剂，因此可用于治疗或预防RSV感染。
• HETEROCYCLIC CARBOXYLATE COMPOUNDS AS GLYCOLATE OXIDASE INHIBITORS
  申请人：GyanRx Sciences, Inc.

  公开号：US20210128532A1

  公开（公告）日：2021-05-06

  The present disclosure relates generally to modulators of human glycolate oxidase enzyme and methods of use and manufacture thereof.
• BENZODIAZEPINE DERIVATIVES FOR TREATING A RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION
  申请人：ReViral Limited

  公开号：US20220409629A1

  公开（公告）日：2022-12-29

  Benzodiazepine derivatives of formula (I): wherein: each of R 1 and R 2 is independently H or halo; R 3 is H, C 1 -C 6 alkyl, —NHR 8 or —OR′; either (i) a, c, and e are all bonds, with b, d and f absent; orb, d and f are all bonds, with a, c and e absent; R 4 is H or a group selected from C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl and 4- to 10-membered heterocyclyl, the group being unsubstituted or substituted; R 5 is H or halo; R 6 is —OR 8 , —NR 8 R 9 or —R 8 ; R 7 is H or halo; each of R 8 and R 9 is independently H or a group selected from C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl and 4- to 10-membered heterocyclyl, the group being unsubstituted or substituted; R′ is H or C 1 -C 6 alkyl; and one of V and W is CH and the other is N or CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.