N-Acetyl-N-ethylalanin | 23619-43-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Acetyl-N-ethylalanin
• 英文别名: N-Acetyl-N-ethylglycine；2-[acetyl(ethyl)amino]acetic acid
• CAS: 23619-43-4
• 化学式: C₆H₁₁NO₃
• 分子量: 145.158
• InChiKey: ZWGZDKQORRWCGT-UHFFFAOYSA-N

物化性质

• 沸点：
  294.6±23.0 °C(Predicted)
• 密度：
  1.146±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 一氧化碳 、 N-乙基乙酰胺 在 palladium on activated charcoal N-甲基吡咯烷酮 、 硫酸 、 lithium bromide 作用下， 130.0 ℃ 、6.0 MPa 条件下， 反应 60.0h， 以78%的产率得到N-Acetyl-N-ethylalanin
  参考文献：
  名称：

  A new improved palladium-catalyzed amidocarbonylation

  摘要：

  A new and improved variant of the palladium-catalyzed amidocarbonylation(1)) to yield N-acyl-alpha-amino acids is described. Using Pd/C as catalyst the products were prepared in good to excellent yields (up to 98 %). Advantages of the Pd/C-catalyst with regard to former catalyst systems are demonstrated by the preparation of N-substituted non-natural amino acids which are of current interest as structural units of peptoids. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00801-1

文献信息

• [EN] HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS<br/>[FR] DÉRIVÉS DE L'ACIDE HYDROXAMIQUE EN TANT QU'AGENTS CONTRE DES BACTÉRIES À GRAM NÉGATIF
  申请人：ASTRAZENECA AB

  公开号：WO2010100475A1

  公开（公告）日：2010-09-10

  The invention relates to chemical compounds of formula (IB): or a salt thereof. In some embodiments, the invention relates to inhibitors of UDP-3-0 — (R-S-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC). In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein and their use in the prevention and/or treatment of Gram- negative bacterial infections.

  该发明涉及化学式(IB)的化合物或其盐。在某些实施例中，该发明涉及UDP-3-0-(R-S-羟基肉豆蔻酰)-N-乙酰葡萄糖胺脱乙酰酶(LpxC)的抑制剂。在更进一步的实施例中，该发明涉及包含本文披露的化合物的药物组合物及其在预防和/或治疗革兰氏阴性细菌感染中的用途。
• Method and materials for repairing electrolytic cell membranes
  申请人：ELTECH SYSTEMS CORPORATION

  公开号：EP0079218A1

  公开（公告）日：1983-05-18

  A method for repairing perfluorocarbon copolymer cation exchange membranes involves partially solvating a quantity of a perfluorocarbon copolymer having a desired pendant cation-exchange functional group, using a solvating dispersion medium. The composition is applied to areas of the membrane to be repaired and the dispersion medium is then removed.

  一种修复全氟碳共聚物阳离子交换膜的方法是利用一种溶解分散介质部分溶解一定量的全氟碳共聚物，该共聚物具有所需的悬垂阳离子交换官能团。将组合物涂抹在需要修复的膜区域，然后去除分散介质。
• Paramagnetic metal ion-based macrocylic magnetization transfer contrast agents and method of use
  申请人：Board of Regents, The University of Texas System

  公开号：US20020127182A1

  公开（公告）日：2002-09-12

  The present invention is directed, in general, to contrast agents (CA), and methods and systems of using such agents for producing image contrast based on a magnetization transfer (MT) mechanism. The CA comprises a tetraazacyclododecane ligand having pendent arms R, R′, R″ and R″′ that are amides having a general formula: —CR 1 H—CO—NH—CH 2 —R 2 . R 1 includes organic substituents and R 2 is not hydrogen. A paramagnetic metal ion (M) is coordinated to the ligand. The method, comprises subjecting a CA, in a sample, to a radio frequency pulse. The CA has pendent arms R, R′, R″ and R″′ comprising organic substituents and the ligand further includes a M and a water molecule. A signal is obtained by applying a radio frequency pulse at a resonance frequency of the water molecule. The magnetic resonance system, comprises a magnetic resonance apparatus and the CA, the agent containing a ligand having the above described general formula.

  本发明一般涉及造影剂（CA），以及使用这种造影剂产生基于磁化转移（MT）机制的图像对比的方法和系统。CA 包括四氮杂环十二烷配体，该配体具有下垂臂 R、R′、R″和 R″′，它们是具有通式的酰胺：-R 1 H-CO-NH-CH 2 -R 2 .R 1 包括有机取代基，R 2 不是氢。顺磁性金属离子（M）与配体配位。该方法包括将样品中的 CA置于射频脉冲下。CA 具有由有机取代基组成的垂臂 R、R′、R″和 R″′，配体还包括 M 和水分子。通过在水分子的共振频率上施加射频脉冲可获得信号。磁共振系统，包括磁共振装置和 CA，该剂含有具有上述通式的配体。
• SYNTHESIS OF COMBINATORIAL ARRAYS OF ORGANIC COMPOUNDS THROUGH THE USE OF MULTIPLE COMPONENT COMBINATORIAL ARRAY SYNTHESES
  申请人：ONTOGEN CORPORATION

  公开号：EP0708751A1

  公开（公告）日：1996-05-01
• VITAMIN D RECEPTOR MODULATORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1565422B1

  公开（公告）日：2009-02-04