2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-methyl-5-trifluoromethyl-3-oxo-2,3-dihydropyridazine | 188489-05-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-methyl-5-trifluoromethyl-3-oxo-2,3-dihydropyridazine
• 英文别名: 2-(4-chloro-2-fluoro-5-hydroxy)phenyl-4-methyl-5-trifluoromethyl-2,3-dihydropyridazin-3-one；2-[2-fluoro-4-chloro-5-hydroxy-phenyl]-4-methyl-5-trifluoromethylpyridazin-3-one；2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4methyl-5-trifluoromethylpyridazin-3-one；S-3153-1-OH；2-(2-fluoro-4-chloro-5-hydroxyphenyl)-4-methyl-5-trifluoromethylpyridazin-3-one；2-[2-fluoro-4-chloro-5-hydroxyphenyl]-4-methyl-5-trifluoromethylpyridazin-3-one；2-(4-Chloro-2-fluoro-5-hydroxyphenyl)-4-methyl-5-(trifluoromethyl)-3(2H)-pyridazinone；2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-methyl-5-(trifluoromethyl)pyridazin-3-one
• CAS: 188489-05-6
• 化学式: C₁₂H₇ClF₄N₂O₂
• 分子量: 322.646
• InChiKey: INGLCBNUVJMQKR-UHFFFAOYSA-N

物化性质

• 沸点：
  369.4±52.0 °C(Predicted)
• 密度：
  1.57±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿；二氯甲烷；甲醇；二甲基亚砜

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2,3-二氯丙烯 、 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-methyl-5-trifluoromethyl-3-oxo-2,3-dihydropyridazine 在 potassium carbonate 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 1.0h， 生成 2-[4-Chloro-5-(2-chloroprop-2-enoxy)-2-fluorophenyl]-4-methyl-5-(trifluoromethyl)pyridazin-3-one
  参考文献：
  名称：

  Pyridazin-3-one derivatives, their use, and intermediates for their production

  摘要：

  提供具有以下结构式的新型肼酮[2]，其中R3为氢、烷基、卤代烷基或烷氧基烷基；Q为[Q-1]、[Q-2]、[Q-3]、[Q-4]或[Q-5]，用于形成除草剂的活性成分的中间体。

  公开号：

  US06348628B1
• 作为产物：
  描述：

  3-carboxy-2-trifluoromethyl-2-hydroxy-1-butanal-1-(4-chloro-2-fluoro-5-hydroxyphenylhydrazone) 在 氮气 、 乙醚 、 盐酸 、 碳酸氢钠 、 magnesium sulfate 作用下， 以 溶剂黄146 、 吡啶 为溶剂， 反应 8.0h， 以Thus, 2-(2-fluoro-4-chloro-5-hydroxyphenyl)-4-methyl-5-trifluoromethylpyridazin-3-on (0.227 g) was obtained的产率得到2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-methyl-5-trifluoromethyl-3-oxo-2,3-dihydropyridazine
  参考文献：
  名称：

  Process for preparing pyridazin-3-on derivatives

  摘要：

  公式（1）的吡啶并嗪-3-酮衍生物：其中R2为氢原子或C1-C3烷基，R3为氢原子或C1-C3烷基，Q为可选取代的苯基，可以在氮含芳香化合物和硼化合物的存在下，通过环合公式（2）的羧酸衍生物或其盐，制备高产率和高纯度的产物，其中R2，R3和Q如上所定义。

  公开号：

  US06500951B1
• 作为试剂：
  描述：

  3,3,3-trifluoro-2-oxopropanal 1-(4-chloro-2-fluoro-5-hydroxyphenylhydrazone) 、 [(1-ethoxycarbonyl)ethylidene]triphenylphosphorane 在 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-methyl-5-trifluoromethyl-3-oxo-2,3-dihydropyridazine 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以afforded 8.8 g of 2-(2-fluoro-4-chloro-5-hydroxyphenyl)-4-methyl-5-trifluoromethylpyridazin-3-one (compound 1-391)的产率得到2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-methyl-5-trifluoromethyl-3-oxo-2,3-dihydropyridazine
  参考文献：
  名称：

  Pyridazin-3-one derivatives, their use, and intermediates for their

  摘要：

  提供了一种公式为[1]的新型吡啶并嗪衍生物，其作为除草剂的活性成分非常有用，其中R.sup.1是卤代烷基；R.sup.2和R.sup.3相同或不同，可以是氢、烷基、卤代烷基或烷氧基烷基；Q是[Q-1]、[Q-2]、[Q-3]、[Q-4]或[Q-5]。此外，还提供了它们的使用方法和生产中间体。

  公开号：

  US06090753A1

文献信息

• Pyridazin-3-one derivatives and their use
  申请人：Sumitomo Chemical Company Limited

  公开号：US06107250A1

  公开（公告）日：2000-08-22

  The present invention provides novel pyridazin-3-one derivatives of general formula (1): ##STR1## wherein R.sup.1 is haloalkyl; R.sup.2 and R.sup.3 are independently hydrogen, alkl, haloalkyl, or alkoxyalkyl; X is hydrogen or halogen; Y is halogen, nitro, cyano, or trihalomethyl; Z.sup.1 is oxygen, sulfur, CH.sub.2, or NH; R.sup.4 is hydrogen, halogen, or alkyl; and R.sup.5 is cycoalkyl, formyl, benzyl, alkyl with an epoxy group, or other substituents as defined in the description, and herbicides containing them as active ingredients.

  本发明提供了一种新型的吡啶并嗪-3-酮衍生物，其一般式为（1）：##STR1## 其中R.sup.1是卤代烷基；R.sup.2和R.sup.3分别是氢、烷基、卤代烷基或烷氧基烷基；X是氢或卤素；Y是卤素、硝基、氰基或三卤甲基；Z.sup.1是氧、硫、CH.sub.2或NH；R.sup.4是氢、卤素或烷基；R.sup.5是环烷基、甲酰基、苄基、带有环氧基的烷基或其他在说明中定义的取代基，以及包含它们作为活性成分的除草剂。
• 6-alkoxycarbonylpyridazin-3-one compounds
  申请人：Sumitomo Chemical Co., Ltd.

  公开号：US06077953A1

  公开（公告）日：2000-06-20

  The 6-alkoxycarbonylpyridazin-3-one compounds given in the formula: ##STR1## wherein, X represents a hydrogen and so on, Y represents a halogen atom, R.sup.1 represents a C.sub.1 -C.sub.6 alkyl group, R.sup.2 represents a hydrogen and other groups as defind, R.sup.3 represents a C.sub.1 -C.sub.3 haloalkoxy group and B represents a hydrogen and other groups as defind, are intermediates to produce the pyridazin-3-one compounds given in the formula: ##STR2## wherein X represents a hydrogen atom and other groups as defind, Y represents a halogen atom, R.sup.2 represents a hydrogen atom and other groups as defind, R.sup.3 represents a C.sub.1 -C.sub.3 haloalkyl group and B represents a hydrogen atom and other groups as defined, which are herbicidal compounds.

  公式为：##STR1## 其中，X代表氢等，Y代表卤素原子，R.sup.1代表C.sub.1-C.sub.6烷基，R.sup.2代表氢和其他定义的基团，R.sup.3代表C.sub.1-C.sub.3卤代氧烷基，B代表氢和其他定义的基团的6-烷氧羰基吡啶嗪-3-酮化合物是生成公式为：##STR2## 其中X代表氢原子和其他定义的基团，Y代表卤素原子，R.sup.2代表氢原子和其他定义的基团，R.sup.3代表C.sub.1-C.sub.3卤代烷基，B代表氢原子和其他定义的基团的除草化合物的中间体。
• Herbicidal composition
  申请人：Sumitomo Chemical Company, Limited

  公开号：US06147030A1

  公开（公告）日：2000-11-14

  A herbicidal composition for foliar treatment is described, which contains as active ingredients, (a) a compound of general formula [1] wherein R is alkyl, cycloalkyl, alkenyl, dimethylamino, or diethylamino; and (b) a compound selected from the group consisting of imazethapyr or a salt thereof, imazaquin or a salt thereof, imazamox or a salt thereof, acifluorfen-sodium, lactofen, fomesafen, clethodim, sethoxydim, fenoxaprop-P-ethyl, fluazifop-P-butyl, and quizalofop-P-ethyl. The herbicidal composition is useful for effective control of a wide variety of weeds in upland fields, particularly in soybean fields. Also described are a weeding method by foliar treatment of weeds with the above herbicidal composition; and use as a herbicide for foliar treatment, of a mixture of the above active ingredients. ##STR1##

  本发明涉及一种叶面处理用除草剂组合物，其包含以下活性成分：(a) 一种通式[1]中R为烷基、环烷基、烯基、二甲基氨基或二乙基氨基的化合物；以及(b) 从以下组中选择的化合物：咪唑草胺或其盐、伊马津赛或其盐、伊马唑喹或其盐、乙酰氟苯酸钠、乳沃苯、福美双、克莱索地、塞托草胺、草灭脲-乙酯、氟草酸丁酯和草丹磷乙酯。该除草剂组合物对于有效控制干地上各种杂草，特别是大豆田非常有用。本发明还涉及一种通过叶面处理使用上述除草剂组合物的除草方法；以及将上述活性成分混合物用作叶面处理用除草剂。##STR1##
• Herbicide compositions
  申请人：Sumitomo Chemical Company, Limited

  公开号：US06197727B1

  公开（公告）日：2001-03-06

  The present invention provides herbicide compositions for foliar treatment each containing as active ingredients, a 2-chloro-4-fluoro-5-(4methyl-5-trifluoromethyl-3-pyridazinon-2-chloro-2-yl)phenyl C1-C5 non-cyclic hydrocarbyl ether and one selected from the group consisting of (RS)-2-(4-chloro-2methylphenoxy)propionic acid, 2,4-dichlorophenoxyacetic acid, (4-chloro-2-methyl)phenoxyacetic acid, 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-amino]carbonyl]amino]sulfonyl] benzoate, 2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide, ethyl (R)-2-[4(6-chloro-1 3-benzoxazol-2-yloxy)phenoxy]propanoate, methyl (RS)-2-[4-(2,4-dichlorophenoxy)phenoxy]propionate, 3,5-dibromo-4-hydroxybenzonitrile, 4-hydroxy-3,5-diiodobenzonitrile, 3-(4-isopropylphenyl)-N′, N′-dimethylurea, N′-(3-chloro-4-methylphenyl)-N,N-dimethylurea and N-(2,4-difluorophenyl)-2-[3-(trifluoromethyl)phenoxy]-3-pyridinecarboxamide; and a weeding method by foliar treatment of weeds therewith. The present compositions can be used for effective control of various weeds occurring on crop lands or non-crop lands, in which case the herbicidal activity is synergistically enhanced as compared with the cases where the active ingredients are used separately, which makes possible low-dose application, and the herbicidal spectra are expanded, so that a wide variety of weeds can be selectively controlled, particularly on wheat, barley, oat, or rye fields.

  本发明提供了一种除草剂组合物，用于叶面处理，每种组合物均含有以下活性成分：2-氯-4-氟-5-(4-甲基-5-三氟甲基-3-吡啶酮-2-氯-2-基)苯基C1-C5非环烃基醚和从以下组合中选择的一种：(RS)-2-(4-氯-2-甲基苯氧基)丙酸、2,4-二氯苯氧乙酸、(4-氯-2-甲基)苯氧乙酸、2-[[[(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)氨基]羰基]氨基]磺酰]苯甲酸酯、2-氯-N-[[[(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)氨基]羰基]苯磺酰]胺、乙基(R)-2-[[4-(6-氯-1,3-苯并噁唑-2-氧基)苯氧基]丙酸酯、甲基(RS)-2-[[4-(2,4-二氯苯氧基)苯氧基]丙酸甲酯、3,5-二溴-4-羟基苯甲腈、4-羟基-3,5-二碘苯甲腈、3-(4-异丙基苯基)-N'，N'-二甲基脲、N'-(3-氯-4-甲基苯基)-N，N-二甲基脲和N-(2,4-二氟苯基)-2-[[3-(三氟甲基)苯氧基]吡啶-3-羧酰胺；以及通过叶面处理除草草本植物的方法。本发明的组合物可用于有效控制作物土地或非作物土地上出现的各种杂草，与单独使用活性成分的情况相比，该除草剂活性具有协同增强作用，从而可以进行低剂量应用，并且除草谱扩展，从而可以选择性地控制各种杂草，特别是在小麦、大麦、燕麦或黑麦田上。
• Pyridazin-3-one derivatives, their use and intermediates for their production
  申请人：Katayama Tadashi

  公开号：US06869913B1

  公开（公告）日：2005-03-22

  Novel pyridazin-3-one derivatives of formula [1] are provided, which are useful as active ingredients of herbicides, wherein R 1 is haloalkyl; R 2 and R 3 are hydrogen, alkyl, haloalkyl, or alkoxyalkyl; and Q is [Q-1], [Q-2], [Q-3], [Q-4] or [Q-5]. Also provided are their use and intermediates for their production.

  本发明提供了式[1]的新型吡啶并嗪酮衍生物，其可用作除草剂的活性成分，其中R1为卤代烷基；R2和R3为氢、烷基、卤代烷基或烷氧基烷基；Q为[Q-1]、[Q-2]、[Q-3]、[Q-4]或[Q-5]。此外，还提供了它们的使用方法和生产中间体。