(E)-3-(2-Ethoxyphenyl)-1-phenyl-2-propen-1-one | 32111-72-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-3-(2-Ethoxyphenyl)-1-phenyl-2-propen-1-one
• 英文别名: (E)-3-(2-ethoxyphenyl)-1-phenylprop-2-en-1-one；2-ethoxy-trans-chalcone；2-Aethoxy-trans-chalkon；2-Ethoxychalcon；(2E)-3-(2-Ethoxyphenyl)-1-phenylprop-2-en-1-one
• CAS: 32111-72-1
• 化学式: C₁₇H₁₆O₂
• 分子量: 252.313
• InChiKey: ICDGTQZUZLBPQV-OUKQBFOZSA-N

物化性质

• 沸点：
  396.6±34.0 °C(Predicted)
• 密度：
  1.095±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-3-(2-Ethoxyphenyl)-1-phenyl-2-propen-1-one 在 polymer-supported poly-L-leucine (PL₅) sodium hydroxide 、 双氧水 作用下， 以 水 、 甲苯 为溶剂， 以56%的产率得到(+)-2,3-Epoxy-3-(2-ethoxyphenyl)-1-phenyl-1-propanone
  参考文献：
  名称：

  Polymer-supported poly(amino acids) as new asymmetric epoxidation catalyst of .alpha.,.beta.-unsaturated ketones

  摘要：

  DOI：

  10.1021/jo00311a024
• 作为产物：
  描述：

  2-乙氧基苯甲醛 、 苯乙酮 在 sodium hydroxide 作用下， 生成 (E)-3-(2-Ethoxyphenyl)-1-phenyl-2-propen-1-one
  参考文献：
  名称：

  Chatterjea; Prasad, Journal Of Scientific and Industrial Research, 1955, vol. 14 B, p. 383,388

  摘要：

  DOI：

文献信息

• Asymmetric epoxidation of α,β-unsaturated ketones catalyzed by silica-grafted poly-(l)-leucine catalysts
  作者：Hua Yi、Gang Zou、Qiang Li、Qun Chen、Jie Tang、Ming-yuan He

  DOI：10.1016/j.tetlet.2005.06.096

  日期：2005.8

  A practical procedure has been developed for grafting poly(amino acid) on silica gel as an efficient and recoverable catalyst in the Juliá–Colonna asymmetric epoxidation with high enantioselectivities. Separation and recovery of the catalyst of poly(amino acid) have been remarkably improved by grafting on silica gel without a significant loss of enantioselectivity and activity.

  已经开发了一种实用程序，可将聚氨基酸接枝到硅胶上，作为具有高对映选择性的朱丽亚-可伦娜不对称环氧化反应中的一种有效且可回收的催化剂。通过在硅胶上接枝，聚氨基酸催化剂的分离和回收得到了显着改善，而对映选择性和活性没有明显损失。
• Specific features of heterocyclization of (E)-3-(2-ethoxyphenyl)-1-phenylprop-2-en-1-one with aminoazoles
  作者：I. G. Ovchinnikova、M. S. Valova、E. G. Matochkina、M. I. Kodess、A. A. Tumashov、P. A. Slepukhin、O. V. Fedorova、G. L. Rusinov、V. N. Charushin

  DOI：10.1007/s11172-014-0635-2

  日期：2014.7

  d chalcone with aminoazoles was studied. The nature of aza groups in aminoazoles was found to affect the regioselectivity of β-amination in the course of the formation of isomeric pyrazolo[3,4-b]pyridine, azolo[1,5-a]- and [4,3-a]-pyrimidine systems and the depth of the reaction were determined. A regulatory role of catalysts and solvents in the direction of the cascade reactions was established. Mechanisms

  研究了 3-(2-乙氧基苯基)-取代的查耳酮与氨基唑的反应。发现氨基唑中氮杂基团的性质在异构吡唑并[3,4-b]吡啶、唑并[1,5-a]-和[4,3-]的形成过程中影响β-胺化的区域选择性a]-嘧啶系统和反应深度被确定。建立了催化剂和溶剂在级联反应方向上的调节作用。提出了反应机理。查尔酮中烷氧基取代基对迈克尔加合物立体选择性合成的意义，包括 3-(2-ethoxyphenyl)-3-(7-(2-ethoxyphenyl)-5-phenyl-6,7-dihydroazolopyrimidin-6-yl)- 1-phenylpropan-1-ones，被证明。通过1H和13C NMR光谱和X射线衍射分析确定合成产物的结构。
• COPOLYMER AND OPTICAL FILM USING SAME
  申请人：Tosoh Corporation

  公开号：EP3553097A1

  公开（公告）日：2019-10-16

  Provided are a novel copolymer which is expected to form an optical film that has excellent retardation characteristics such as high retardation even in a thin film and an optical film using the same. A copolymer comprising a residue unit A represented by the general formula (1) and a residue unit B represented by the general formula (2): wherein R1 and R2 each independently represent hydrogen (provided that the case where R1 and R2 are both hydrogen is eliminated), a cyano group, an ester group (-C(=O)OX1), an amide group (-C(=O)N(X2)(X3)), or an acyl group (-C(=O)X4) (where X1 to X3 each independently represent a linear alkyl group having 1 to 12 carbon atoms, a branched alkyl group having 1 to 12 carbon atoms, or a cyclic alkyl group having 3 to 6 carbon atoms, and X4 represents a linear alkyl group having 1 to 12 carbon atoms, a branched alkyl group having 1 to 12 carbon atoms, or a cyclic group having 3 to 14 carbon atoms); R3 to R7 each independently represent hydrogen, a linear alkyl group having 1 to 12 carbon atoms, a branched alkyl group having 1 to 12 carbon atoms, a cyclic group having 3 to 14 carbon atoms, a halogen, a hydroxy group, a carboxy group, a nitro group, a cyano group, an alkoxy group (-OX5), an ester group (-C(=O)OX6), an amide group (-C(=O)N(X7)(X8)), an acyl group (-C(=O)X9), an amino group (-N(X10)(X11)), or a sulfonic acid group (-SOOX12) (where X5 to X8 each independently represent a linear alkyl group having 1 to 12 carbon atoms, a branched alkyl group having 1 to 12 carbon atoms, or a cyclic alkyl group having 3 to 6 carbon atoms, X9 to X12 each independently represent hydrogen, a linear alkyl group having 1 to 12 carbon atoms, a branched alkyl group having 1 to 12 carbon atoms, or a cyclic alkyl group having 3 to 6 carbon atoms); and adjacent substituents among R3 to R7 may form a fused ring structure each other, wherein R8 represents an m-membered heterocyclic residue containing one or more heteroatoms or a 5-membered or 6-membered ring residue containing no heteroatom (provided that, when R8 is a 6-membered ring residue containing no heteroatom, at least one of R3 to R7 in the general formula (1) represents a hydroxy group), and m represents an integer of 5 to 10; and the m-membered heterocyclic residue, the 5-membered ring residue, and the 6-membered ring residue may form a fused ring structure.

  本发明提供了一种新型共聚物，该共聚物可望形成一种光学薄膜，该光学薄膜具有优异的延缓特性，例如即使在薄膜中也具有高延缓性，本发明还提供了使用该共聚物的光学薄膜。 由通式（1）表示的残留单元 A 和通式（2）表示的残留单元 B 组成的共聚物： 其中 R1 和 R2 各自独立地代表氢（前提是排除 R1 和 R2 都是氢的情况）、氰基、酯基（-C(＝O)OX1）、酰胺基（-C(＝O)N(X2)(X3)）或酰基（-C(＝O)X4）（其中 X1 至 X3 各自独立地代表具有 1 至 12 个碳原子的直链烷基、具有 1 至 12 个碳原子的支链烷基或具有 3 至 6 个碳原子的环状烷基，而 X4 代表具有 1 至 12 个碳原子的直链烷基、具有 1 至 12 个碳原子的支链烷基或具有 3 至 14 个碳原子的环状基团）；R3 至 R7 各自独立地代表氢、具有 1 至 12 个碳原子的直链烷基、具有 1 至 12 个碳原子的支链烷基、具有 3 至 14 个碳原子的环基、卤素羟基、羧基、硝基、氰基、烷氧基 (-OX5)、酯基 (-C(=O)OX6)、酰胺基 (-C(=O)N(X7)(X8))、酰基 (-C(=O)X9)、氨基 (-N(X10)(X11))、或磺酸基（-SOOX12）（其中 X5 至 X8 各自独立地代表具有 1 至 12 个碳原子的直链烷基、具有 1 至 12 个碳原子的支链烷基或具有 3 至 6 个碳原子的环状烷基，X9 至 X12 各自独立地代表氢、具有 1 至 12 个碳原子的直链烷基、具有 1 至 12 个碳原子的支链烷基或具有 3 至 6 个碳原子的环状烷基）；R3 至 R7 中的相邻取代基可相互形成融合环结构、 其中 R8 代表含有一个或多个杂原子的 m 元杂环残基或不含杂原子的 5 元或 6 元环残基（条件是，当 R8 是不含杂原子的 6 元环残基时，通式（1）中 R3 至 R7 中至少有一个代表羟基），且 m 代表 5 至 10 的整数；且 m 元杂环残基、5 元环残基和 6 元环残基可形成融合环结构。
• Copolymer and optical film using same
  申请人：TOSOH CORPORATION

  公开号：US11225540B2

  公开（公告）日：2022-01-18

  A novel copolymer suitable for an optical film which is excellent in optical characteristics and has high retardation even in a thin film state, and an optical film containing the same are provided. A copolymer excellent in optical characteristics and easy to form a composite with a different polymer, and an optical film composed of the same are also provided.

  本发明提供了一种适用于光学薄膜的新型共聚物，这种共聚物具有优异的光学特性，即使在薄膜状态下也具有较高的延缓性，本发明还提供了一种含有这种共聚物的光学薄膜。此外，还提供了一种光学特性优异且易于与其他聚合物形成复合材料的共聚物，以及由其构成的光学薄膜。
• Synthesis of oxocyclohexenecarboxylic acids and podands derived therefrom under heterogeneous catalysis
  作者：M. S. Valova、O. V. Koryakova、I. N. Ganebnykh、A. N. Murashkevich、O. V. Fedorova

  DOI：10.1134/s1070428014100066

  日期：2014.10

  Nanosized Al, Mg, and Ti-Si oxides, as well as barium hydroxide, have been tested as heterogeneous catalysts in the Robinson reaction with 2-ethoxy-substituted chalcone and podands based thereon. Barium hydroxide catalyzes the first step of the Robinson reaction, Michael addition, while its activity in the second step involving intramolecular cyclization and dehydration is lower. Nanosized oxides effectively catalyze the second step of the Robinson reaction and hamper elimination of the carboxy group. Procedures have been developed for the synthesis of oxocyclohexenecarboxylic acid derivatives and symmetric and asymmetric podands based thereon.