1,2-di(4-methoxyphenoxy)-2-propene | 199923-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,2-di(4-methoxyphenoxy)-2-propene
• 英文别名: 2,3-Bis(4-methoxyphenoxy)propene；1-methoxy-4-[2-(4-methoxyphenoxy)prop-2-enoxy]benzene
• CAS: 199923-55-2
• 化学式: C₁₇H₁₈O₄
• 分子量: 286.328
• InChiKey: UQRICKSMJITSQC-UHFFFAOYSA-N

物化性质

• 沸点：
  427.5±40.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基苯基氧化钠 、 2,3-二溴-1-丙烯 在 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 以71%的产率得到1,2-di(4-methoxyphenoxy)-2-propene
  参考文献：
  名称：

  涉及钯金环丁烷的新反应：酚盐离子对1-和2-溴（π-烯丙基）钯配合物中心碳的攻击

  摘要：

  酚盐离子的亲核攻击主要发生在卤素取代的（π-烯丙基）Pd配合物的中心碳上。

  DOI：

  10.1016/s0040-4039(97)10252-0

文献信息

• Selective synthesis of functionalized allylic compounds by Pd(0)-catalyzed three-component reaction of methyl propargyl carbonate with phenols and nucleophiles
  作者：Noriyuki Nishioka、Toshio Koizumi

  DOI：10.1016/j.tetlet.2011.05.030

  日期：2011.7

  A Pd(0)-catalyzed three-component reaction of methyl propargyl carbonate with phenols and nucleophiles is described. The reaction proceeded smoothly and various allylic compounds were synthesized selectively in good to excellent yields under neutral conditions. The regioselective introduction of functional groups into the allylic compounds could also be achieved. The reaction with nitrogen and carbon

  描述了Pd（0）催化的碳酸炔丙酯与酚和亲核试剂的三组分反应。反应进行顺利，并且在中性条件下以良好至优异的收率选择性地合成了各种烯丙基化合物。也可以实现将官能团区域选择性地引入烯丙基化合物中。与氮和碳亲核试剂的反应主要得到2-芳氧基烯丙基化合物。另一方面，脂族醇得到2-烷氧基烯丙基化合物。
• On the regiochemistry of nucleophilic attack on 2-halo π-allyl complexes. Part 3: The electronic effect of phenoxide ion and the ligand
  作者：Michael G. Organ、Elena A. Arvanitis、Stephen J. Hynes

  DOI：10.1016/s0040-4039(02)02183-4

  日期：2002.12

  2,3-Dibromo-1-propene was subjected to competitive attack by malonate and different phenoxide nucleophiles in the presence of Pd substituted with monodentate or bidentate ligands. The presence of phenoxide promotes central carbon attack on the initially-formed 2-bromo Pd-pi-allyl complex by malonate in the presence of mono or bidentate ligands on Pd. However, bidentate ligands on Pd disfavour the attack of phenoxide, either at the central position or the terminal position of either of the two pi-ally complexes formed during the course of these di-additions. (C) 2002 Elsevier Science Ltd. All rights reserved.
• New reactions involving palladacyclobutanes: The attack of phenoxide ion at the central carbon of both 1- and 2-bromo(π-allyl)palladium complexes
  作者：Michael G Organ、Michael Miller

  DOI：10.1016/s0040-4039(97)10252-0

  日期：1997.11

  Nucleophilic attack of phenoxide ion occurs primarily at the central carbon of halo-substituted (π-allyl)Pd complexes.

  酚盐离子的亲核攻击主要发生在卤素取代的（π-烯丙基）Pd配合物的中心碳上。