4,5-Dichloro-2-(1,3-thiazol-2-yl)pyridazin-3-one | 1295575-74-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4,5-Dichloro-2-(1,3-thiazol-2-yl)pyridazin-3-one
• 英文别名: 4,5-dichloro-2-(1,3-thiazol-2-yl)pyridazin-3-one
• CAS: 1295575-74-4
• 化学式: C₇H₃Cl₂N₃OS
• 分子量: 248.092
• InChiKey: RHQZHGIPLHLWNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,5-Dichloro-2-(1,3-thiazol-2-yl)pyridazin-3-one 在 盐酸 、 sodium hexamethyldisilazane 、 三乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醇 、 二氯甲烷 为溶剂， 生成 4-Cyclopentyloxy-5-(4-propan-2-ylsulfonylpiperazin-1-yl)-2-(1,3-thiazol-2-yl)pyridazin-3-one
  参考文献：
  名称：

  The synthesis and structure–activity relationship of pyridazinones as glucan synthase inhibitors

  摘要：

  A structure-activity relationship study of the lead 5-[4-(benzylsulfonyl) piperazin-1-yl]-4-morpholino-2- phenyl-pyridazin-3(2H)-one 1 has resulted in the identification of 2-(3,5-difluorophenyl)-4-(3-fluorocyclopentyloxy)- 5-[4-(isopropylsulfonyl) piperazin-1-yl]-pyridazin-3(2H)-one 11c as a beta- 1,3-glucan synthase inhibitor. Compound 11c exhibited significant efficacy in an in vivo mouse model of Candida glabrata infection. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.058
• 作为产物：
  描述：

  2-肼噻唑盐酸盐 、 糠氯酸 在 sodium hydroxide 作用下， 生成 4,5-Dichloro-2-(1,3-thiazol-2-yl)pyridazin-3-one
  参考文献：
  名称：

  The synthesis and structure–activity relationship of pyridazinones as glucan synthase inhibitors

  摘要：

  A structure-activity relationship study of the lead 5-[4-(benzylsulfonyl) piperazin-1-yl]-4-morpholino-2- phenyl-pyridazin-3(2H)-one 1 has resulted in the identification of 2-(3,5-difluorophenyl)-4-(3-fluorocyclopentyloxy)- 5-[4-(isopropylsulfonyl) piperazin-1-yl]-pyridazin-3(2H)-one 11c as a beta- 1,3-glucan synthase inhibitor. Compound 11c exhibited significant efficacy in an in vivo mouse model of Candida glabrata infection. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.058

文献信息

• The synthesis and structure–activity relationship of pyridazinones as glucan synthase inhibitors
  作者：Pauline C. Ting、Rongze Kuang、Heping Wu、Robert G. Aslanian、Jianhua Cao、David W. Kim、Joe F. Lee、John Schwerdt、Gang Zhou、Samuel Wainhaus、Todd A. Black、Anthony Cacciapuoti、Paul M. McNicholas、Yiming Xu、Scott S. Walker

  DOI：10.1016/j.bmcl.2011.01.058

  日期：2011.3

  A structure-activity relationship study of the lead 5-[4-(benzylsulfonyl) piperazin-1-yl]-4-morpholino-2- phenyl-pyridazin-3(2H)-one 1 has resulted in the identification of 2-(3,5-difluorophenyl)-4-(3-fluorocyclopentyloxy)- 5-[4-(isopropylsulfonyl) piperazin-1-yl]-pyridazin-3(2H)-one 11c as a beta- 1,3-glucan synthase inhibitor. Compound 11c exhibited significant efficacy in an in vivo mouse model of Candida glabrata infection. (C) 2011 Elsevier Ltd. All rights reserved.