2-Dimethylamino-2-methylpropancarbonsaeureethylester | 51015-89-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Dimethylamino-2-methylpropancarbonsaeureethylester
• 英文别名: 2-(Dimethylamino)-2-methylpropansaeure-ethylester；α-dimethylamino-isobutyric acid ethyl ester；α-Dimethylamino-isobuttersaeure-aethylester；N,N-Dimethyl-α-aminoisobuttersaeureaethylester；ethyl N,N,2-trimethylalaninate；ethyl 2-(dimethylamino)-2-methylpropanoate
• CAS: 51015-89-5
• 化学式: C₈H₁₇NO₂
• 分子量: 159.228
• InChiKey: OCULCHLXBPBUBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Dimethylamino-2-methylpropancarbonsaeureethylester 、 diborane(6) 以 neat (no solvent) 为溶剂， 生成
  参考文献：
  名称：

  Cyclic borane derivatives of amino acids

  摘要：

  DOI：

  10.1021/ic50136a041
• 作为产物：
  描述：

  2-溴-2-甲基丙酸乙酯 、 二甲胺 反应 10.0h， 以37.5%的产率得到2-Dimethylamino-2-methylpropancarbonsaeureethylester
  参考文献：
  名称：

  合成这些von 1,1-Diphenylaminoalkoholen

  摘要：

  Es wird über die Synthese des 2-Amino-2-methyl-1,1-diphenyl-1-propanols (2a), seiner kernsubstituierten 和 N-alkylierten Derivate aus Aminosäureestern und Grignardverbindungen berichtet。Die Grenzen dieser Synthese, andere Möglichkeiten zur Darstellung von Aminoalkoholen und die hierbei erhaltenen Produkte werden beschrieben。

  DOI：

  10.1002/ardp.19813140109

文献信息

• DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS
  申请人：Matsuyama Hironori

  公开号：US20100004438A1

  公开（公告）日：2010-01-07

  An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X 1 represents a nitrogen atom or a group —CH═, R 1 represents a group -Z-R 6 , in which Z represents a group —CO—, a group —CH(OH)— or the like, R 6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R 2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R 3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R 4 represents an imidazolyl lower alkyl group or the like.

  本发明的一个目的是提供一种在抗肿瘤活性方面大大改进且安全性优异的药物。根据本发明，提供了一种包含以下一般式（1）所表示的化合物或其盐作为活性成分的药物：[式1]其中X1代表氮原子或基团—CH═，R1代表一个基团-Z-R6，其中Z代表基团—CO—，基团—CH(OH)—或类似的基团，R6代表一个含有1至4个氮原子、氧原子或硫原子的5至15个成员的单环、双环或三环饱和或不饱和杂环基团，R2代表氢原子或卤原子，Y代表基团—O—，基团—CO—，基团—CH(OH)—或低碳烷基基团，A代表[式2]其中R3代表氢原子、低碳氧基基团或类似基团，p代表1或2，R4代表咪唑基低碳基团或类似基团。
• Aromatic Compounds
  申请人：Fukushima Tae

  公开号：US20070270422A1

  公开（公告）日：2007-11-22

  The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X 1 represents a nitrogen atom or a group —CH═; R 1 represents a group -Z-R 6 , wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R 6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R 2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R 3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R 4 represents an imidazolyl lower alkyl group or the like.

  本发明提供了一种新型化合物，具有抑制胶原生成的优异效果，并且具有较少的副作用，在安全性方面表现出色。本发明的化合物由以下通式（1）表示：[其中X1代表氮原子或基团—CH═；R1代表基团-Z-R6，其中Z代表基团—CO—、基团—CH(OH)—或类似基团，而R6代表具有1到4个氮原子、氧原子或硫原子的5-到15元的单环、双环或三环、饱和或不饱和杂环基团；R2代表氢原子、卤素原子或低碳链基团；Y代表基团—O—、基团—CO—、基团—CH(OH)—、低碳链基团或类似基团；A代表基团或类似基团，其中R3代表氢原子、低碳醚基团或类似基团，p代表1或2，而R4代表咪唑基低碳基团或类似基团。
• AROMATIC COMPOUND
  申请人：FUKUSHIMA Tae

  公开号：US20120238750A1

  公开（公告）日：2012-09-20

  The compound of the present invention is represented by the following general formula (1): [wherein X 1 represents a nitrogen atom or a group —CH═; R 1 represents a group —Z—R 6 , wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R 6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R 2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R 3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R 4 represents an imidazolyl lower alkyl group or the like.

  本发明的化合物由以下通式（1）表示：[其中X1表示氮原子或基团—CH═; R1表示基团—Z—R6，其中Z表示基团—CO—、基团—CH（OH）—或类似物，而R6表示具有1至4个氮原子、氧原子或硫原子的5至15环的单环、双环或三环、饱和或不饱和的杂环基团; R2表示氢原子、卤素原子或较低的烷基链; Y表示基团—O—、基团—CO—、基团—CH（OH）—、较低的烷基链或类似物; A表示基团或类似物，其中R3表示氢原子、较低的烷氧基或类似物，p表示1或2，而R4表示咪唑基较低的烷基链或类似物。
• ANTIMICROBIAL COMPOUNDS AND METHODS OF USE
  申请人：NexMed Holdings, Inc.

  公开号：US20150079163A1

  公开（公告）日：2015-03-19

  The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.

  本公开提供抗微生物化合物、包含该类抗微生物化合物的组合物以及它们的使用方法，特别是抗菌化合物和抗真菌化合物。在某些方面，这些抗微生物化合物对医院获得性感染的病原体有效。在某些方面，这些抗微生物化合物对抗生素耐药的病原体有效。这些抗微生物化合物可以用于抗菌组合物、抗真菌组合物、防腐组合物和消毒组合物。这些抗微生物化合物可以用作抗菌组合物和抗真菌组合物的辅助剂。
• Hair conditioner for wavy and curly hair
  申请人：Kao USA, Inc.

  公开号：US10179102B2

  公开（公告）日：2019-01-15

  The present application discloses hair conditioning compositions which provide effective hair conditioning, particularly to wavy or curly hair, the conditioning benefit lasting in the hair over several (up to 10) subsequent shampooings. The compositions comprise a film-forming polyester that is the reaction product of at least one diol, at least one polyol, and at least one dicarboxylic acid; polyquaternium-52 and/or polyquaternium-37; and at least one amino or aminopropyl-functional silicone, in an aqueous vehicle. The composition may additionally include dimethicone and/or a branched-chain ester. The method of conditioning hair using the defined compositions is also disclosed.

  本申请公开了护发组合物，可有效护发，特别是对波浪或卷发，其护发功效可在头发上持续数次（最多 10 次）。该组合物包括在水性载体中的成膜聚酯，它是至少一种二元醇、至少一种多元醇和至少一种二羧酸的反应产物；聚季铵盐-52 和/或聚季铵盐-37；以及至少一种氨基或氨丙基官能团硅氧烷。组合物还可包括二甲基硅氧烷和/或支链酯。此外，还公开了使用所定义的组合物调理头发的方法。