2-bromo-3-isobutylthiophene | 786456-99-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 2-bromo-3-isobutylthiophene
• 英文别名: 2-Bromo-3-(2-methylpropyl)thiophene；2-bromo-3-(2-methylpropyl)thiophene
• CAS: 786456-99-3
• 化学式: C₈H₁₁BrS
• 分子量: 219.145
• InChiKey: AXQHOFLGRCTYDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-bromo-3-isobutylthiophene 在 N-溴代丁二酰亚胺(NBS) 、 四(三苯基膦)钯 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 26.0h， 生成 3,3'4'',4'''-tetraisobutyl-2,5':2',2'':5'',2'''-quaterthiophene
  参考文献：
  名称：

  Oligothiophene Isocyanides for Platinum-Based Molecular Electronic Applications

  摘要：

  Understanding molecular orientation on a metal surface is key to designing molecular electronic device junctions. Though platinum device electrodes are of particular interest as a more stable alternative to the often used gold electrodes, the chemisorption of conducting molecules onto platinum surfaces has not been thoroughly studied. We present herein the first detailed study of the ability and manner in which soluble oligothiophene isocyanides, of lengths ranging from 2 to 7 nm, chemisorb onto platinum surfaces and nanoparticles. It was found that these oligothiophene isocyanides stand at a 41 degrees angle from the platinum surface normal, suggesting their applicability in molecule-bridged platinum electrode devices.

  DOI：

  10.1021/ja045904p
• 作为产物：
  描述：

  3-(isobutyl)thiophene 在 溴 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以98%的产率得到2-bromo-3-isobutylthiophene
  参考文献：
  名称：

  Oligothiophene Isocyanides for Platinum-Based Molecular Electronic Applications

  摘要：

  Understanding molecular orientation on a metal surface is key to designing molecular electronic device junctions. Though platinum device electrodes are of particular interest as a more stable alternative to the often used gold electrodes, the chemisorption of conducting molecules onto platinum surfaces has not been thoroughly studied. We present herein the first detailed study of the ability and manner in which soluble oligothiophene isocyanides, of lengths ranging from 2 to 7 nm, chemisorb onto platinum surfaces and nanoparticles. It was found that these oligothiophene isocyanides stand at a 41 degrees angle from the platinum surface normal, suggesting their applicability in molecule-bridged platinum electrode devices.

  DOI：

  10.1021/ja045904p

文献信息

• BICYCLO [2.2.1] ACID GPR120 MODULATORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160016880A1

  公开（公告）日：2016-01-21

  The present invention provides compounds of Formula (I): (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.

  本发明提供了Formula (I)的化合物：(I)或其立体异构体，或其药用可接受的盐，其中所有变量如本文所定义。这些化合物是GPR120 G蛋白偶联受体调节剂，可用作药物。
• US9518000B2
  申请人：——

  公开号：US9518000B2

  公开（公告）日：2016-12-13
• Oligothiophene Isocyanides for Platinum-Based Molecular Electronic Applications
  作者：Dennis Bong、Iris Tam、Ronald Breslow

  DOI：10.1021/ja045904p

  日期：2004.9.1

  Understanding molecular orientation on a metal surface is key to designing molecular electronic device junctions. Though platinum device electrodes are of particular interest as a more stable alternative to the often used gold electrodes, the chemisorption of conducting molecules onto platinum surfaces has not been thoroughly studied. We present herein the first detailed study of the ability and manner in which soluble oligothiophene isocyanides, of lengths ranging from 2 to 7 nm, chemisorb onto platinum surfaces and nanoparticles. It was found that these oligothiophene isocyanides stand at a 41 degrees angle from the platinum surface normal, suggesting their applicability in molecule-bridged platinum electrode devices.