2-(4-fluorophenyl)-4-hydroxypyrimidine-5-carbonitrile | 30748-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(4-fluorophenyl)-4-hydroxypyrimidine-5-carbonitrile
• 英文别名: 2-(4-Fluorophenyl)-1,6-dihydro-6-oxo-5-pyrimidinecarbonitrile；2-(4-fluorophenyl)-6-oxo-1H-pyrimidine-5-carbonitrile
• CAS: 30748-60-8
• 化学式: C₁₁H₆FN₃O
• 分子量: 215.187
• InChiKey: XHSILRSYQBGLPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-fluorophenyl)-4-hydroxypyrimidine-5-carbonitrile 在 三氯氧磷 作用下， 以1.0 g的产率得到4-chloro-2-(4-fluorophenyl)pyrimidine-5-carbonitrile
  参考文献：
  名称：

  [EN] 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD
  [FR] 2-PYRAZOLE ANILINES ET ANALOGUES APPARENTÉS POUR INHIBER YAP/TAZ-TEAD

  摘要：

  The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.

  公开号：

  WO2023122780A2
• 作为产物：
  描述：

  4-氟苄脒盐酸盐 、 2-cyano-3-ethoxyacrylic acid ethyl ester 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以1.2 g的产率得到2-(4-fluorophenyl)-4-hydroxypyrimidine-5-carbonitrile
  参考文献：
  名称：

  [EN] 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD
  [FR] 2-PYRAZOLE ANILINES ET ANALOGUES APPARENTÉS POUR INHIBER YAP/TAZ-TEAD

  摘要：

  The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.

  公开号：

  WO2023122780A2

文献信息

• [EN] 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD<br/>[FR] 2-PYRAZOLE ANILINES ET ANALOGUES APPARENTÉS POUR INHIBER YAP/TAZ-TEAD
  申请人：[en]THE KATHOLIEKE UNIVERSITEIT LEUVEN

  公开号：WO2023122780A2

  公开（公告）日：2023-06-29

  The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.