(2-Bromo-3-methoxy-5-phenylmethoxyphenyl)methanol | 97227-86-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Bromo-3-methoxy-5-phenylmethoxyphenyl)methanol
• 英文别名: (2-bromo-3-methoxy-5-phenylmethoxyphenyl)methanol
• CAS: 97227-86-6
• 化学式: C₁₅H₁₅BrO₃
• 分子量: 323.186
• InChiKey: LDUUMXGWTBRGTJ-UHFFFAOYSA-N

物化性质

• 沸点：
  455.1±40.0 °C(Predicted)
• 密度：
  1.416±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-Bromo-3-methoxy-5-phenylmethoxyphenyl)methanol 在 吡啶 、 palladium dihydroxide 、 potassium permanganate 、 重铬酸吡啶 、 正丁基锂 、 Bu₄(NH₄) 、 potassium carbonate 、 三苯基膦 、 环己烯 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 硫赭曲菌素
  参考文献：
  名称：

  Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation

  摘要：

  Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00305-4
• 作为产物：
  描述：

  3-(苄氧基)-5-羟基苯甲酸甲酯 在 N-溴代丁二酰亚胺(NBS) 、 lithium aluminium tetrahydride 、 potassium carbonate 作用下， 以 四氢呋喃 、 四氯化碳 、 乙腈 为溶剂， 生成 (2-Bromo-3-methoxy-5-phenylmethoxyphenyl)methanol
  参考文献：
  名称：

  Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation

  摘要：

  Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00305-4

文献信息

• Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation
  作者：Hiroshi Ohashi、Akihiro Ueno、Toyoo Nakao、Junko Ito、Kaname Kimura、Masaharu Ishikawa、Hiroyuki Kawai、Hiroshi Iijima、Tatsushi Osawa

  DOI：10.1016/s0960-894x(99)00305-4

  日期：1999.7

  Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described. (C) 1999 Elsevier Science Ltd. All rights reserved.