N-stearoyl-glutamic acid | 29923-36-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-stearoyl-glutamic acid
• 英文别名: stearoyl glutamic acid；2-(Octadecanoylamino)pentanedioic acid
• CAS: 29923-36-2
• 化学式: C₂₃H₄₃NO₅
• 分子量: 413.598
• InChiKey: ATFFFUXLAJBBDE-UHFFFAOYSA-N

物化性质

• 沸点：
  600.3±45.0 °C(Predicted)
• 密度：
  1.024±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  29
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  DL-谷氨酸 、 十八烷酰氯 在 sodium hydroxide 作用下， 以 水 、 丙酮 为溶剂， 反应 1.5h， 生成 N-stearoyl-glutamic acid
  参考文献：
  名称：

  螺旋碳载体上单铁位点的压缩应变调制促进电催化氧还原

  摘要：

  设计和调节金属位点的局部结构是获得单金属位点催化剂独特选择性和高活性的关键。在此，我们报告了弯曲单原子铁氮位点的应变工程，以提高电催化活性。首先，通过以自组装手性表面活性剂为模板的螺旋聚吡咯的碳化，实现了具有丰富高曲率表面的螺旋碳结构。高曲率表面在支撑的 Fe-N 4位点上引入压缩应变。因此，弯曲的 Fe-N 4具有 1.5% 压缩 Fe-N 键的位点比平面位点表现出下移的 d 带中心。这种变化会削弱含氧中间体和金属位点之间的结合强度，导致氧还原的能垒小得多。催化测试进一步证明，在碱性介质中，弯曲的 Fe-N 4位点在 0.9 V vs. RHE 下获得了 7.922 mA cm -2的动电流密度，比平面高 31 倍。我们的研究结果阐明了调节单个金属位点的局部三维结构并通过应变工程提高催化活性。

  DOI：

  10.1002/anie.202109058

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• [EN] METHODS OF TREATING OR AMELIORATING METABOLIC DISORDERS USING GROWTH DIFFERENTIATION FACTOR 15 (GDF-15)<br/>[FR] MÉTHODES DE TRAITEMENT OU D'AMÉLIORATION DE TROUBLES MÉTABOLIQUES À L'AIDE DU FACTEUR-15 DE CROISSANCE ET DE DIFFÉRENCIATION (GDF-15)
  申请人：NOVARTIS AG

  公开号：WO2017109706A1

  公开（公告）日：2017-06-29

  The disclosure relates to the treatment of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), as well as end-stage liver disease, hepatic steatosis (fatty liver), liver fibrosis, liver inflammation, liver cirrhosis, primary biliary cirrhosis (PBC), and hepatocellular carcinoma (HCC), by administering to a subject in need a GDF15 protein or a functional variant, mutation, fusion, or conjugate thereof, and to pharmaceutical compositions that contain the same.

  该披露涉及通过向需要的受试者施用GDF15蛋白或其功能变体、突变体、融合物或结合物，以及含有相同成分的药物组合物，治疗非酒精性脂肪肝病（NAFLD）和非酒精性脂肪性肝炎（NASH），以及晚期肝病、肝脂肪变性（脂肪肝）、肝纤维化、肝炎、肝硬化、原发性胆汁性肝硬化（PBC）和肝细胞癌（HCC）。
• MICRO/NANO MATERIALS, PRODUCTS OBTAINED BY COVALENTLY MODIFYING SURFACE OF MICRO/NANO MATERIALS WITH HYDROPHILIC MATERIALS, AND METHOD FOR MAKING SAME
  申请人：CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD.

  公开号：US20190077746A1

  公开（公告）日：2019-03-14

  Micro-nano materials, products obtained by covalently modifying the surfaces of micro/nano materials with hydrophilic materials, and methods for making the same. The micro/nano materials on the surfaces have carboxyl groups or/and pro-carboxyl groups which are converted into their active esters. The products are covalently modified by forming amide bonds between the active esters on the surfaces and the modification agents; where the modification agents are hydrophilic compounds and/or hydrophilic polymers bearing primary and/or secondary aliphatic amines. Monomers bearing carboxyl groups and/or pro-carboxyl groups are used to produce an adequate number of carboxyl groups and/or pro-carboxyl groups on the surface of a polymer material to be modified. The carboxyl groups and/or pro-carboxyl groups are converted into active esters. A reasonably-sized modification agent bearing primary and/or secondary amines, zwitterions and hydrophilic linear spacer arms is used to form amide bonds and obtain a covalently modified surface layer.

  微纳米材料，通过用亲水材料共价修饰微/纳米材料表面获得的产品，以及制备这些产品的方法。表面上的微/纳米材料具有羧基或/和前羧基，这些羧基或前羧基被转化为它们的活性酯。通过在表面上的活性酯和修饰剂之间形成酰胺键，共价修饰的产品；其中修饰剂是带有一次和/或二次脂肪胺基的亲水化合物和/或亲水性聚合物。使用带有羧基和/或前羧基的单体来产生足够数量的羧基和/或前羧基，以便在待修饰的聚合物材料表面上形成。将羧基和/或前羧基转化为活性酯。使用合理大小的带有一次和/或二次胺基、带有带电离子和亲水性线性间隔臂的修饰剂来形成酰胺键，并获得共价修饰的表面层。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Organic compounds
  申请人：Givaudan S.A.

  公开号：US10836712B2

  公开（公告）日：2020-11-17

  A flavour composition comprising a compound according to the formula (I) or edible salts thereof, wherein R1 is an alkyl residue containing 6 to 20 carbon atoms, or an alkene residue containing from 9 to 25 carbon atoms with 1 to 6 double bonds, R1 together with the carbonyl group to which it is attached is a residue of a carboxylic acid, and NR2R3, in which R3 is H or together with R2 and the N-atom to which they are attached, a 5-membered ring, is a residue of an amino acid, in particular a proteinogenic amino acid, ornithine, gamma-aminobutyric acid or beta alanine, or a 1-amino cycloalkyl carboxylic acid.

  一种包含符合式(I)的化合物或其可食用盐的风味组合物，其中R1是含有6至20个碳原子的烷基残基，或者含有9至25个碳原子且具有1至6个双键的烯烃残基，R1与其连接的羰基一起是羧酸的残基，NR2R3中，R3为H或与R2和它们连接的N原子一起是一个5元环的残基，是一种氨基酸的残基，特别是一种蛋白质原性氨基酸、鸟氨酸、γ-氨基丁酸或β-丙氨酸，或者是一种1-氨基环烷基羧酸的残基。