N-isopentylmethacrylamide | 110613-29-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-isopentylmethacrylamide
• 英文别名: Methacrylamide, N-(3-methylbutyl)-；2-methyl-N-(3-methylbutyl)prop-2-enamide
• CAS: 110613-29-1
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: IOTUYWDLDODZIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-isopentylmethacrylamide 在 palladium on activated charcoal 三异丙氧基氯化钛 、 盐酸 、 正丁基锂 、 氢气 、 间氯过氧苯甲酸 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 为溶剂， 反应 31.0h， 生成
  参考文献：
  名称：

  基于新型二肽类似物的肾素抑制剂。在易裂键处引入脱氢羟基乙烯等排酯。

  摘要：

  描述了肾素抑制剂的设计和合成，该抑制剂结合了新型二肽等排物（4S，5S）-5-氨基-6-环己基-4-羟基己基-1-烯-2-羧酸作为过渡态类似物。钛促进的二锂化N-烷基甲基丙烯酰胺与受保护的氨基醛缩合，可有效制备受保护的二肽类似物7和8。将7掺入血管紧张素原的部分序列可提供有效的人肾素体外抑制剂。对不饱和酰胺部分的进一步化学处理允许研究P1'和P2'位点的结构-活性关系。介绍了合成，立体化学测定和体外肾素抑制的详细信息。

  DOI：

  10.1021/jm00394a008

文献信息

• Glaucoma treatment
  申请人：Abbott Laboratories

  公开号：US04927807A1

  公开（公告）日：1990-05-22

  A method and a composition for treating or reducing and/or controlling intraocular pressure comprising administering an effective amount of a renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 wherein R.sub.2 is hydrogen or loweralkyl; with the proviso that when W is CHOH then U is CH.sub.2 ; R.sub.1 is loweralkyl, cycloalkyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-hydroxybenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino; R.sub.3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, benzyl or heterocyclic ring substituted methyl; and R.sub.4 is a substituted amino group; or pharmaceutically acceptable salts or esters thereof. Also disclosed are compositions, methods and kits for treating glaucoma or reducing and/or controlling intraocular pressure wherein the renin inhibiting compound is administered in combination with a beta-adrenergic antagonist, a steroidal antiinflammatory agent or an angiotensin converting enzyme inhibiting compound.

  一种用于治疗或减少和/或控制眼内压的方法和组合物，包括给予有效量的一种肾素抑制化合物，该化合物的化学式为：##STR1## 其中A是取代基；W是CO或CHOH，U是CH.sub.2或NR.sub.2，其中R.sub.2是氢或低碳基；但当W是CHOH时，U是CH.sub.2；R.sub.1是低碳基，环烷基，苯甲基，(α，α)-二甲基苯甲基，4-羟基苯甲基，4-甲氧基苯甲基，卤代苯甲基，(1-萘基)甲基，(2-萘基)甲基，(4-咪唑基)甲基，苯乙基，1-苄氧基乙基，苯氧基，噻吩氧基或苯胺基；R.sub.3是低碳基，低烯基，((烷氧基)烷氧基)烷基，羧基烷基，(硫代烷氧基)烷基，苯甲基或杂环环取代甲基；而R.sub.4是取代氨基基团；或其药学上可接受的盐或酯。还公开了用于治疗青光眼或减少和/或控制眼内压的组合物、方法和试剂盒，其中肾素抑制化合物与β-肾上腺素受体拮抗剂、类固醇抗炎药或血管紧张素转换酶抑制剂联合给药。
• Non-peptide renin inhibitors
  申请人：ABBOTT LABORATORIES

  公开号：EP0364804A1

  公开（公告）日：1990-04-25

  A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), S02, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.

  式中的肾素抑制化合物： 其中 A 是取代基；R1 是氢、低级烷基、取代的低级烷基或低级烯基；X 是 CH2、CHOH、C(O)、O、S、S(O)、S02、NH、N(O)或-P(O)O-；R3 是低级烷基、低级烯基或取代的低级烷基；T 是血管紧张素原的 Leu-Val 裂解位点的模拟物；或其药学上可接受的盐、酯或原药。
• Thermosensitive copolymers, and forward osmosis water treatment devices and methods of using the same
  申请人：Samsung Electronics Co., Ltd

  公开号：EP2641927A1

  公开（公告）日：2013-09-25

  Disclosed is a thermosensitive copolymer, which includes a first repeating unit having a temperature-sensitive oligomer grafted thereto and a second repeating unit having an ionic moiety and a counter ion to the ionic moiety, wherein the temperature-sensitive oligomer is an oligomer including a repeating unit derived from a unsaturated monomer with a moiety represented by Chemical Formula 1 or Chemical Formula 2, or an oligomer including a repeating unit derived from a heterocyclic compound having C, N, and O and having a C=N bond in its ring.          [Chemical Formula 1]     *-C(=O)N(R2)(R3) In Chemical Formula 1, R2 and R3 are each independently hydrogen or a linear or branched C1 to C6 alkyl group, a C3 to C7 cycloalkyl group, or a C6 to C10 aryl group, R2 and R3 are not both be hydrogen, and R2 and R3 may be combined to form a nitrogen containing heterocycle. In Chemical Formula 2, R4 is a C2 to C5 alkylene group.

  本发明公开了一种热敏共聚物，它包括具有接枝到其上的热敏低聚物的第一重复单元和具有离子基团及离子基团的反离子的第二重复单元，其中热敏低聚物是一种低聚物，包括从具有化学式 1 或化学式 2 所代表的基团的不饱和单体衍生的重复单元，或包括从具有 C、N 和 O 且在其环中具有 C=N 键的杂环化合物衍生的重复单元的低聚物。 [化学式 1] *-C(=O)N(R2)(R3) 在化学式 1 中 R2 和 R3 各自独立地为氢或直链或支链 C1 至 C6 烷基、C3 至 C7 环烷基或 C6 至 C10 芳基，R2 和 R3 不能都是氢，R2 和 R3 可结合形成含氮杂环。 在化学式 2 中，R4 是 C2 至 C5 亚烷基。
• SURFACE TREATMENT METHOD, SURFACE TREATMENT LIQUID, AND SURFACE-TREATED ARTICLE
  申请人：Tokyo Ohka Kogyo Co., Ltd.

  公开号：EP3476464A1

  公开（公告）日：2019-05-01

  To provide a surface treatment method capable of successfully making a treatment target including polyimide on a surface thereof hydrophilic or hydrophobic with a safe operation; a two-liquid type surface treatment liquid that can be suitably used for the surface treatment method; and a surface-treated polyimide product that can be obtained by the above-described surface treatment method. A first resin having a primary amino group and/or a hydroxyl group, and a secondary amino group is bonded to a surface of a treatment target including polyimide on a surface thereof, and then a second resin having a (meth)acryloyl group and/or a carbamoyl group, a hydrophilic group and/or a hydrophobic group is bonded to the first resin.

  提供一种表面处理方法，该方法能够成功地使处理目标（包括其表面的聚酰亚胺）亲水或疏水，且操作安全；提供一种双液型表面处理液，该处理液可适当用于该表面处理方法；以及提供一种表面处理过的聚酰亚胺产品，该产品可通过上述表面处理方法获得。将具有伯氨基和/或羟基和仲氨基的第一种树脂粘合到包括聚酰亚胺在内的处理目标的表面上，然后将具有（甲基）丙烯酰基和/或氨基甲酰基、亲水基团和/或疏水基团的第二种树脂粘合到第一种树脂上。
• SURFACE TREATMENT LIQUID AND SURFACE TREATMENT METHOD
  申请人：Tokyo Ohka Kogyo Co., Ltd.

  公开号：EP3476904A1

  公开（公告）日：2019-05-01

  To provide a surface treatment liquid capable of making a base material including polyorganosiloxane on at least a part of a surface thereof hydrophilic stably over a long period of time, and provide a surface treatment method using the surface treatment liquid. In a surface treatment liquid including (A) resin and a (B) solvent, as the (A) resin, resin having a functional group I that is a hydroxyl group and/or a cyano group is used, and a functional group II that is a hydrophilic group other than the functional group I, and a ratio of a structural unit having an anionic group to total structural units of the (A) resin is 5 mol% or less, or resin including a cationic group including an anion moiety and a cation moiety that can be bonded to the (A) resin is used.

  提供一种表面处理液，该表面处理液能够使包括聚有机硅氧烷在内的基质材料的至少部分表面长期稳定地亲水，并提供一种使用该表面处理液的表面处理方法。在包括（A）树脂和（B）溶剂的表面处理液中，作为（A）树脂，使用具有羟基和/或氰基官能团 I 的树脂，以及具有除官能团 I 以外的亲水性官能团 II 的官能团，且具有阴离子基团的结构单元占（A）树脂的总结构单元的比例为 5 mol%或以下，或使用具有阳离子基团的树脂，该阳离子基团包括阴离子基团和可与（A）树脂结合的阳离子基团。