8-[[Furan-2-ylmethyl(methyl)amino]methyl]-5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one | 1021312-26-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 8-[[Furan-2-ylmethyl(methyl)amino]methyl]-5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
• CAS: 1021312-26-4
• 化学式: C₂₃H₂₁NO₆
• 分子量: 407.423
• InChiKey: KDMYADANUHLKCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  92.4
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-甲基糠基胺 、 聚合甲醛 、 千层纸素A 以 异丙醇 为溶剂， 生成 8-[[Furan-2-ylmethyl(methyl)amino]methyl]-5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
  参考文献：
  名称：

  Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as α-glucosidase inhibitors

  摘要：

  A series of 8-aminomethylated derivatives (1a-1j) were prepared by Mannich reaction of oroxylin A (1) with appropriate primary or secondary amines and para-formaldehyde. All the compounds were tested for their alpha-glucosidase inhibition activity against both yeast and rat intestinal alpha-glucosidase. Some of the compounds demonstrated significantly better alpha-glucosidase inhibitory activity than the parent compound (oroxylin A). (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.01.055