3-Octyloxy-propionsaeure-octylester | 94434-74-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Octyloxy-propionsaeure-octylester
• 英文别名: 3-octyloxy-propionic acid octyl ester；octyl 3-(octyloxy)propanoate；3-Octyloxy-propionic acid octyl ester；octyl 3-octoxypropanoate
• CAS: 94434-74-9
• 化学式: C₁₉H₃₈O₃
• 分子量: 314.509
• InChiKey: HVBILFHICZRGTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  辛醇 、 Schwefelsaeure-<2-carbamoyl-aethylester> 生成 3-Octyloxy-propionsaeure-octylester
  参考文献：
  名称：

  Zil'berman,E.N.; Michurin,A.A., Journal of general chemistry of the USSR, 1963, vol. 33, p. 2694 - 2698

  摘要：

  DOI：

文献信息

• Process for the manufacture of 2-ethylhexyl acrylate
  申请人：ATOFINA

  公开号：US20020193623A1

  公开（公告）日：2002-12-19

  2-Ethylhexyl acrylate is obtained by esterification of acrylic acid (AA) with 2-ethylhexanol (2-EtHexOH), in the presence of at least one stabilizer for AA, with H 2 SO 4 as catalyst, the crude reaction mixture (B 1 ) obtained comprising the desired acrylate, 2-EtHexOH, AA, 2-ethylhexyl hydrogensulphate (2-EtHexSO 4 H), traces of H 2 SO 4 and impurities. (B 1 ) is washed with water in an extraction column C 2 to remove, at the bottom, the aqueous phase (A 1 ), the top organic phase (O 2 ) being sent to a topping column C 3 to obtain, at the top, the AA and the 2-EtHexOH, which are recycled to the esterification, the topped desired acrylate being sent to a distillation column C 4 , from where it exits, purified from the heavy products; a stage of hydrolysis of the 2-EtHexSO 4 H present in (A 1 ) being carried out to form, in this phase, 2-EtHexOH and H 2 SO 4 , the acidic entities resulting from the hydrolysis being neutralized by introduction of a base into the medium, and the resulting aqueous phase (A 3 ) being sent to the recovery of the 2-EtHexOH in a distillation column C 1.

  2-乙基己基丙烯酸酯是通过丙烯酸（AA）与2-乙基己醇（2-EtHexOH）在至少一种AA稳定剂的存在下酯化得到的，硫酸（H2SO4）作为催化剂，得到的粗反应混合物（B1）包括所需的丙烯酸酯、2-EtHexOH、AA、2-乙基己基硫酸酯（2-EtHexSO4H）、少量H2SO4和杂质。将（B1）在萃取柱C2中用水洗涤，底部去除水相（A1），将顶部有机相（O2）送入顶部柱C3，以得到顶部的AA和2-EtHexOH，这些被回收用于酯化，而顶部的所需丙烯酸酯被送入蒸馏柱C4，从中纯化出来，经重质产品退出；将（A1）中存在的2-乙基己基硫酸酯进行水解，生成2-乙基己醇和H2SO4，水解产生的酸性物质通过向介质中引入碱来中和，所得的水相（A3）被送入蒸馏柱C1中回收2-乙基己醇。
• INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA
  申请人：Ammendola Aldo

  公开号：US20090192192A1

  公开（公告）日：2009-07-30

  The present invention relates to the use of compounds as broad spectrum inhibitors of bacterial biofilm formation. In particular the invention refers to a family of compounds that block the quorum sensing system of Gram-negative and Gram-positive bacteria, a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of bacterial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.

  本发明涉及使用化合物作为广谱细菌生物膜形成的抑制剂。具体而言，本发明涉及一系列化合物，能够阻断革兰氏阴性和革兰氏阳性细菌的群体感应系统，一种制造它们的方法，含有它们的制药组合物以及它们用于治疗和预防细菌损害和疾病的用途，特别是对于需要抑制病原体的群体感应调节表型的疾病有优势的情况。
• Preparation and Physical Properties of n-Alkyl β-n-Alkoxypropionates
  作者：C. E. Rehberg、Marion B. Dixon、C. H. Fisher

  DOI：10.1021/ja01204a010

  日期：1947.12
• [EN] INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA<br/>[FR] INHIBITEURS DE LA FORMATION DE BIOFILMS DE BACTÉRIES GRAM POSITIF ET GRAM NÉGATIF
  申请人：QUONOVA LLC

  公开号：WO2009077844A3

  公开（公告）日：2009-11-05
• US2870195
  申请人：——

  公开号：——

  公开（公告）日：——