N,N-ethylbutylacetamide | 10601-68-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-ethylbutylacetamide
• 英文别名: ethylbutylacetamide；N-Butyl-N-ethyl acetamide；Essigsaeure-；N-Butyl-N-ethylacetamide
• CAS: 10601-68-0
• 化学式: C₈H₁₇NO
• mdl: MFCD01741319
• 分子量: 143.229
• InChiKey: OCEMJNHDGIPDDE-UHFFFAOYSA-N

物化性质

• 沸点：
  207.3±8.0 °C(Predicted)
• 密度：
  0.868±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-乙基正丁胺 、 乙酰氯 以 乙醚 为溶剂， 生成 N,N-ethylbutylacetamide
  参考文献：
  名称：

  N-烷基酰胺的自氧化。第一部分N-乙酰胺作为氧化产物

  摘要：

  已经鉴定了N-烷基-和NN-二烷基酰胺的热和光敏自氧化的产物。Ñ -n烷基酰胺得到主要Ñ -acylamides，伯酰胺，和Ñ -formylamides，如从与氮相邻碳氢原子的初始抽象的结果。的形成Ñ -formylamides，以及Ñ从-acylamides Ñ -s-三烷基酰胺，涉及Ç （1） -C （2）键的断裂中ñ -烷基。NN的氧化-二烷基酰胺遵循相似的模式。给出了89种酰胺的气相色谱-液相色谱保留数据。

  DOI：

  10.1039/j29660000690

文献信息

• [EN] SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS<br/>[FR] TRIAZOLES AMINO-SUBSTITUÉS UTILES EN TANT QU'INHIBITEURS DE CHITINASE HUMAINE
  申请人：ONCOARENDI THERAPEUTICS SP Z O O

  公开号：WO2017037670A1

  公开（公告）日：2017-03-09

  Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.

  揭示了一种氨基三唑化合物，其带有一个被杂环环取代的哌啶环。这些化合物是酸性哺乳动物几丁质酶和几丁三糖酶的抑制剂。还公开了使用这些化合物治疗由过敏原引起的哮喘反应，以及急性和慢性炎症性疾病、自身免疫疾病、牙科疾病、神经系统疾病、代谢性疾病、肝脏疾病、多囊卵巢综合征、子宫内膜异位症和癌症的方法。
• 2-Phenyl-2h-pyridazine-3-ones
  申请人：——

  公开号：US20030162662A1

  公开（公告）日：2003-08-28

  The invention relates to 2-phenyl-2H-pyridazin-3-ones of the general formula I 1 in which the variables R 1 , R 2 , X, Y and Z have the following meanings: X is halogen; Y is fluorine or chlorine; Z is oxygen; R 1 is hydrogen or C 1 -C 4 -alkyl; R 2 is chlorine, OR 3 or NR 4 R 5 , in which R 3 , R 4 and R 5 have the meanings indicated in claim 1, Z can also be a group NR 6 if R 2 is a group OR 7 , in which R 6 and R 7 have the meanings indicated in claim 1, and to the agriculturally utilizable salts of compounds of the formula I. The invention furthermore relates to the use of compounds I and their salts as herbicides and/or for the desiccation and/or defoliation of plants, herbicidal compositions and compositions for the desiccation and/or defoliation of plants, which contain the compounds I and/or their salts as active substances, and processes for controlling undesired vegetation (weeds) and for the desiccation and/or defoliation of plants using the compounds I and/or their salts.

  该发明涉及一般式I中的2-苯基-2H-吡啶并三酮，其中变量R1、R2、X、Y和Z具有以下含义：X为卤素；Y为氟或氯；Z为氧；R1为氢或C1-C4-烷基；R2为氯、OR3或NR4R5，其中R3、R4和R5具有权利要求1中所指的含义，如果R2为OR7，则Z也可以是NR6基团，其中R6和R7具有权利要求1中所指的含义，并且该发明还涉及一般式I化合物的农业可利用盐。此外，该发明涉及将化合物I及其盐用作除草剂和/或用于植物脱水和/或落叶，含有化合物I和/或其盐作为活性物质的除草剂组合物和用于植物脱水和/或落叶的组合物，以及利用化合物I和/或其盐控制不受欢迎的植被（杂草）和对植物进行脱水和/或落叶的过程。
• Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer
  申请人：——

  公开号：US20030092757A1

  公开（公告）日：2003-05-15

  Disclosed herein is a method for favorably modulating the health-related quality of life and the health-related quality-adjusted time-to-disease progression in a patient having prostate cancer and a method for measuring of the health-related quality-adjusted time-to-disease progression.

  本文揭示了一种有利地调节患有前列腺癌患者的健康相关生活质量和健康相关质量调整的疾病进展时间的方法，以及一种测量健康相关质量调整的疾病进展时间的方法。
• Photo stable organic sunscreen compositions
  申请人：EMD CHEMICALS, INC.

  公开号：US20040247536A1

  公开（公告）日：2004-12-09

  Photostable broad-spectrum organic sunscreen compositions comprising a UV-A sunscreen, such as Avobenzone, a photostabilizer, a UV-B liquid organic sunscreen, and a solubilizer and further enhancing the photostability by encapsulation using a sol-gel process.

  具有光稳定性的广谱有机防晒霜组合物包括UV-A防晒霜，如阿伏苯宗，光稳定剂，UV-B液体有机防晒霜，溶解剂，并通过溶胶-凝胶过程进行封装以进一步增强光稳定性。
• Benzimidazole and Pyridylimidazole Derivatives
  申请人：Li Guiying

  公开号：US20080227793A1

  公开（公告）日：2008-09-18

  This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABA A receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABA A receptors in tissue sections.

  本发明涉及苯并咪唑、吡啶咪唑和相关的双环杂芳烃化合物，所有这些化合物都可以用公式I描述。本发明特别涉及与GABAA受体的苯二氮卓位点具有高选择性和高亲和力的这种化合物。本发明还涉及包含这种化合物的制药组合物以及在治疗某些中枢神经系统（CNS）疾病中使用这种化合物的用途。还公开了制备公式I化合物的新方法。本发明还涉及将公式I的苯并咪唑、吡啶咪唑和相关的双环杂芳烃化合物与一个或多个其他CNS药剂联合使用以增强其他CNS药剂的效果。此外，本发明还涉及将这些化合物用作定位组织切片中的GABAA受体的探针。