ethyl 2-(N,N-dimethylamino)-propionate | 82614-49-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2-(N,N-dimethylamino)-propionate
• 英文别名: N,N-dimethylalanine ethyl ester；N,N-dimethyl-DL-alanine ethyl ester；N,N-Dimethyl-DL-alanin-aethylester；DL-2-Dimethylamino-propionsaeure-aethylester；N,N-Dimethyl-alanin-aethylester；Inakt.α-Dimethylamino-propionsaeure-aethylester；Dimethyl-dl-alanin-aethylester；ethyl 2-(dimethylamino)propanoate
• CAS: 82614-49-1
• 化学式: C₇H₁₅NO₂
• 分子量: 145.202
• InChiKey: UPGMLKNCPUCDSU-UHFFFAOYSA-N

物化性质

• 沸点：
  156.5 °C
• 密度：
  0.9207 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 2-(N,N-dimethylamino)-propionate 在 水 、 sodium hydroxide 、 盐酸 作用下， 以 水 为溶剂， 反应 4.5h， 以100%的产率得到2-(二甲基氨基)丙酸
  参考文献：
  名称：

  EP3091003

  摘要：

  公开号：
• 作为产物：
  描述：

  Dimethyl-(1-ethoxycarbonyl-ethyl)-<3-methyl-buten-(2)-yl>-ammonium 以 乙醚 为溶剂， 生成 ethyl 2-(N,N-dimethylamino)-propionate
  参考文献：
  名称：

  Babayan,A.T. et al., Journal of Organic Chemistry USSR (English Translation), 1966, vol. 2, p. 1939 - 1945

  摘要：

  DOI：

文献信息

• [EN] NOVEL INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)<br/>[FR] NOUVEAUX INDOLE-2-CARBOXAMIDES ACTIFS CONTRE LE VIRUS DE L'HÉPATITE B (VHB)
  申请人：AICURIS GMBH & CO KG

  公开号：WO2020221826A1

  公开（公告）日：2020-11-05

  The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

  本发明一般涉及新型抗病毒药剂。具体地，本发明涉及能够抑制乙型肝炎病毒（HBV）编码的蛋白质或干扰HBV复制周期功能的化合物，包括这种化合物的组合物，抑制HBV病毒复制的方法，治疗或预防HBV感染的方法，以及制备这些化合物的工艺和中间体。
• [EN] NOVEL PHENYL AND PYRIDYL UREAS ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)<br/>[FR] NOUVELLES URÉES DE PHÉNYLE ET DE PYRIDYLE ACTIVES CONTRE LE VIRUS DE L'HÉPATITE B (VHB)
  申请人：AICURIS GMBH & CO KG

  公开号：WO2020221816A1

  公开（公告）日：2020-11-05

  The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

  本发明一般涉及新型抗病毒剂。具体地，本发明涉及能够抑制乙型肝炎病毒（HBV）编码的蛋白质或干扰HBV复制周期功能的化合物，包含这种化合物的组合物，抑制HBV病毒复制的方法，治疗或预防HBV感染的方法，以及制备这些化合物的工艺和中间体。
• The electrochemical fluorination of nitrogen-containing carboxylic acids. Fluorination of dimethylamino- or diethylamino-substituted carboxylic acid derivatives
  作者：Takashi Abe、Eiji Hayashi、Hajime Baba、Haruhiko Fukaya

  DOI：10.1016/s0022-1139(00)80438-8

  日期：1990.6

  The electrochemical fluorination of six derivatives of dimethylamino- or diethylamino-substituted carboxylic acids has been conducted. As the main fluorination products, cyclized and cleaved products as well as the desired N-containing perfluoroacid fluorides were formed, and their ratios depended on the chain length and the structure of the starting carboxylic acids, and the nature of the dialkylamino

  已经进行了二甲氨基或二乙氨基取代的羧酸的六种衍生物的电化学氟化。作为主要的氟化产物，形成环化和裂解的产物以及所需的含N的全氟氟化物，它们的比例取决于链长和起始羧酸的结构以及二烷基氨基的性质。通过这项工作，全氟（二甲基氨基-乙酰氟），全氟（二乙基氨基-乙酰氟），全氟（2-二甲基氨基-丙酰氟），全氟（2-二甲基氨基-丁酰氟）和全氟（3-二甲基氨基-丙酰氟）是准备好了。
• Aminomethyl chromans
  申请人：Beecham Group Limited

  公开号：US04303656A1

  公开（公告）日：1981-12-01

  A compound of the general formula (III), having anorexic activity: ##STR1## or a salt thereof, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and are each a hydrogen or halogen atom, or a trifluoromethyl, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxyl, carboxyl, C.sub.1 to C.sub.4 alkoxycarbonyl, amino or acetamido group; R.sub.6 is a hydrogen atom or a C.sub.1 to C.sub.4 alkyl group; X is a straight or branched alkylene group of up to 4 carbon atoms; and R.sub.7 and R.sub.8 which may be the same or different are each a hydrogen atom or a C.sub.1 to C.sub.4 alkyl group, or R.sub.7 is joined to R.sub.8 so that NR.sub.7 R.sub.8 forms a 5-7 membered heterocyclic ring.

  通式（III）的化合物，具有厌食活性：##STR1##或其盐，其中R.sub.1、R.sub.2、R.sub.3和R.sub.4可以相同也可以不同，每个都是氢或卤素原子，或三氟甲基，C.sub.1到C.sub.4烷基，C.sub.1到C.sub.4烷氧基，羟基，羧基，C.sub.1到C.sub.4烷氧羰基，氨基或乙酰氨基；R.sub.6是氢原子或C.sub.1到C.sub.4烷基；X是最多含有4个碳原子的直链或支链烷基基团；R.sub.7和R.sub.8可以相同也可以不同，每个都是氢原子或C.sub.1到C.sub.4烷基，或R.sub.7与R.sub.8结合，使NR.sub.7R.sub.8形成5-7成员杂环环。
• ANTIMICROBIAL COMPOUNDS AND METHODS OF USE
  申请人：NEXMED HOLDINGS, INC.

  公开号：US20140170207A1

  公开（公告）日：2014-06-19

  The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.

  本公开提供抗微生物化合物，包含这些抗微生物化合物的组合物，以及它们的使用方法，特别是抗菌化合物和抗真菌化合物。在某些方面，这些抗微生物化合物对医院感染的病原体具有有效性。在某些方面，这些抗微生物化合物对抗生素耐药的病原体具有有效性。这些抗微生物化合物可用于抗菌组合物、抗真菌组合物、防腐剂组合物和消毒剂组合物。这些抗微生物化合物可用作抗菌组合物和抗真菌组合物的辅助剂。