N-acetyl-sulfanilic acid-(2-chloro-ethylamide) | 90943-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-acetyl-sulfanilic acid-(2-chloro-ethylamide)
• 英文别名: N-Acetyl-sulfanilsaeure-(2-chlor-aethylamid)；Essigsaeure-[4-(2-chlor-aethylsulfamoyl)-anilid]；4-Acetamino-benzolsulfonsaeure-(1)-(2-chlor-ethylamid)；4-Acetamino-benzolsulfonsaeure-(2-chlor-ethylamid)；N-[4-(2-chloroethylsulfamoyl)phenyl]acetamide
• CAS: 90943-47-8
• 化学式: C₁₀H₁₃ClN₂O₃S
• 分子量: 276.744
• InChiKey: YOKNRRCFHGEJTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-acetyl-sulfanilic acid-(2-chloro-ethylamide) 在 盐酸 作用下， 生成 4-Amino-benzolsulfonsaeure-(2-chlor-ethylamid)
  参考文献：
  名称：

  Brintzinger; Pfannstiel; Koddebusch, Chemische Berichte, 1949, vol. 82, p. 389,397

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯乙胺盐酸盐 、 对乙酰胺基苯磺酰氯 在 吡啶 作用下， 生成 N-acetyl-sulfanilic acid-(2-chloro-ethylamide)
  参考文献：
  名称：

  Brintzinger; Pfannstiel; Koddebusch, Chemische Berichte, 1949, vol. 82, p. 389,397

  摘要：

  DOI：

文献信息

• Compositions useful in treating brain-related diseases or disorders and methods using same
  申请人：DREXEL UNIVERSITY

  公开号：US10287290B2

  公开（公告）日：2019-05-14

  The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.

  本发明提供了用于治疗或预防脑相关疾病或紊乱的化合物。本发明进一步提供了一种治疗或预防患者脑相关疾病或紊乱的方法，包括向患者施用包含至少一种本发明化合物的药物组合物。本发明进一步提供了一种调节单胺转运体活性的方法。
• NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME
  申请人：DREXEL UNIVERSITY

  公开号：US20160074408A1

  公开（公告）日：2016-03-17

  The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, the method comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.
• US9616065B2
  申请人：——

  公开号：US9616065B2

  公开（公告）日：2017-04-11
• [EN] NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME<br/>[FR] NOUVELLES COMPOSITIONS UTILISÉES POUR LE TRAITEMENT DE MALADIES OU D'AFFECTIONS LIÉES AU CERVEAU, ET MÉTHODES UTILISANT CES COMPOSITIONS
  申请人：PHILADELPHIA HEALTH & EDUCATIO

  公开号：WO2014172453A2

  公开（公告）日：2014-10-23

  The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.
• Brintzinger; Pfannstiel; Koddebusch, Chemische Berichte, 1949, vol. 82, p. 389,397
  作者：Brintzinger、Pfannstiel、Koddebusch

  DOI：——

  日期：——