leptosin I

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: leptosin I
• 英文别名: (1R,2R,4R,7S,10R,18S,19R,27S,30R,37R)-37-hydroxy-7-(hydroxymethyl)-6,36-dimethyl-30-propan-2-yl-3-oxa-31,32,33,34-tetrathia-6,9,11,26,28,36-hexazadecacyclo[28.4.2.14,18.01,28.02,19.04,9.010,18.012,17.019,27.020,25]heptatriaconta-12,14,16,20,22,24-hexaene-5,8,29,35-tetrone
• 化学式: C₃₂H₃₂N₆O₇S₄
• 分子量: 740.906
• InChiKey: PZFMMBJJDMZAIP-ZHAQRSJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  49
• 可旋转键数：
  2
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  256
• 氢给体数：
  4
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 leptosin I 在 吡啶 作用下， 以4.2 mg的产率得到leptosin I diacetate
  参考文献：
  名称：

  Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures.

  摘要：

  Leptosins I and J, belonging to a series of epipolythiodioxopiperazines, have been isolated from the mycelium of a strain of Leptosphaeria sp. OUPS-4 attached to the marine alga Sargasssum tortile. Their relative stereostructures have been elucidated by chemical and spectral evidence. These compounds exhibited significant cytotoxic activity against cultured P388 cells.

  DOI：

  10.7164/antibiotics.47.1242

文献信息

• Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures.
  作者：CHIKA TAKAHASHI、ATSUSHI NUMATA、EIKO MATSUMURA、KATSUHIKO MINOURA、HIROKI ETO、TETSURO SHINGU、TADAYOSHI ITO、TORU HASEGAWA

  DOI：10.7164/antibiotics.47.1242

  日期：——

  Leptosins I and J, belonging to a series of epipolythiodioxopiperazines, have been isolated from the mycelium of a strain of Leptosphaeria sp. OUPS-4 attached to the marine alga Sargasssum tortile. Their relative stereostructures have been elucidated by chemical and spectral evidence. These compounds exhibited significant cytotoxic activity against cultured P388 cells.