methacryloyl sulfamethazine | 59941-98-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methacryloyl sulfamethazine
• 英文别名: N-<4-(4,6-Dimethyl-2-pyrimidinylsulfamoyl)-phenyl>-methacrylamid；N-[4-(4,6-dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-2-methyl-acrylamide；N-{4-[(4,6-Dimethyl-2-pyrimidinyl)sulfamoyl]phenyl}-2-methylacrylamide；N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-methylprop-2-enamide
• CAS: 59941-98-9
• 化学式: C₁₆H₁₈N₄O₃S
• 分子量: 346.41
• InChiKey: FTDWQQAHMIKKGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,4,6-三甲基溴化苄 、 methacryloyl sulfamethazine 在 sodium hydride 作用下， 以 四氢呋喃 、 paraffin oil 为溶剂， 反应 0.08h， 以1.47 g的产率得到N-(4-(N-(4,6-dimethylpyrimidin-2-yl)-N-(2,4,6-trimethylbenzyl)sulfamoyl)phenyl)-N-(2,4,6-trimethylbenzyl)methacrylamide
  参考文献：
  名称：

  N-杂环碳烯催化的休斯-微笑通过未活化的C（芳基）-N键的裂解重新排列N-芳基丙烯酰胺

  摘要：

  我们报道了N-杂环卡宾（NHC）催化的苯胺衍生物的Truce-Smiles重排，其中未活化的C（芳基）-N键被裂解，导致形成新的C（芳基）-C键。该反应成功的关键是利用高度亲核的NHC，它能够形成由α，β-不饱和酰胺生成的高度亲核的叶立德中间体。

  DOI：

  10.1021/acs.orglett.0c04281
• 作为产物：
  描述：

  磺胺二甲嘧啶 、 甲基丙烯酰氯 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 methacryloyl sulfamethazine
  参考文献：
  名称：

  N-杂环碳烯催化的休斯-微笑通过未活化的C（芳基）-N键的裂解重新排列N-芳基丙烯酰胺

  摘要：

  我们报道了N-杂环卡宾（NHC）催化的苯胺衍生物的Truce-Smiles重排，其中未活化的C（芳基）-N键被裂解，导致形成新的C（芳基）-C键。该反应成功的关键是利用高度亲核的NHC，它能够形成由α，β-不饱和酰胺生成的高度亲核的叶立德中间体。

  DOI：

  10.1021/acs.orglett.0c04281

文献信息

• lithographic printing plate precursor
  申请人：André Xavier

  公开号：US20120088191A1

  公开（公告）日：2012-04-12

  A positive-working lithographic printing plate precursor is disclosed which comprises on a support having a hydrophilic surface or which is provided with a hydrophilic layer a heat and/or light-sensitive coating including an infrared absorbing agent and a compound including a benzoxazine group.

  本发明揭示了一种阳性光刻印刷版前体，其包括在具有亲水表面或具有亲水层的支撑体上的热和/或光敏涂层，包括红外吸收剂和含有苯并噁嗪基团的化合物。
• New Alkali Soluble Resin
  申请人：Loccufier Johan

  公开号：US20110247516A1

  公开（公告）日：2011-10-13

  An alkali soluble resin is disclosed comprising a first monomeric unit including at least one sulfonamide group and a second monomeric unit derived from the monomer according to the following structure (I) wherein R 1 represents a structural moiety comprising an ethylenically unsaturated polymerisable group; R 2 , R 3 and R 4 independently represent hydrogen, an optionally substituted alkyl, alkenyl, alkynyl, alkaryl, aralkyl, aryl or heteroaryl group or, the necessary atoms to form a five to eight membered ring.

  揭示了一种碱溶性树脂，包括第一单体单元，其中包括至少一个磺酰胺基团和从具有以下结构（I）的单体得到的第二单体单元，其中R1表示包括乙烯基不饱和可聚合基团的结构基团; R2、R3和R4独立地表示氢、可选地取代的烷基、烯基、炔基、烷基芳基、芳基烷基、芳基或杂环芳基基团或形成五至八元环所必需的原子。
• A lithographic printing plate precursor
  申请人：Agfa Graphics N.V.

  公开号：EP2489512A1

  公开（公告）日：2012-08-22

  A positive-working lithographic printing plate precursor which comprises on a support having a hydrophilic surface or which is provided with a hydrophilic layer, a heat and/or light-sensitive coating comprising an infrared absorbing agent and a binder including a monomeric unit including a salicyclic acid group and a monomeric unit including a sulfonamide group.

  一种正向工作平版印刷板前体，它包括在具有亲水表面或提供亲水层的支撑物上的热敏和/或光敏涂层，该涂层由红外线吸收剂和粘合剂组成，粘合剂包括包括水杨酸基团的单体单元和包括磺酰胺基团的单体单元。
• Tunable pH- and CO₂-Responsive Sulfonamide-Containing Polymers by RAFT Polymerization
  作者：Brooks A. Abel、Michael B. Sims、Charles L. McCormick

  DOI：10.1021/acs.macromol.5b01453

  日期：2015.8.25

  The controlled RAFT polymerization of a library of pH- and CO2-responsive methacryloyl sulfonamides (MSAs) that possess pK(a) values in the biologically relevant regime (pH = 4.5-7.4) is reported. Initial polymerizations were conducted at 70 degrees C in DMF with 4-cyano-4-(ethylsulfanylthiocarbonylsulfanyl)pentanoic acid (CEP) or 4-cyanopentanoic acid dithiobenzoate (CTP), resulting in polymers of broad molecular weight distributions (K-w/M-n > 1.20). As well, chain extension of a poly(methacryloyl sulfacetamide) (pSAC) macro-CTA at 70 degrees C was unsuccessful, indicating a loss of "living" chain ends during polymerization. However, by conducting the RAFT polymerization of MSAs at 30 degrees C with 2,2'-azobis(4-methoxy-2,4-dimethylvaleronitrile), polymers with narrow molecular weight distributions (M-w/M-n < 1.15) and improved chain end retention were obtained. Homopolymers of each MSA derivative were synthesized, and the influence of the sulfonamide R group on monomer pK(a) and pH-dependent polymer solubility was determined during these studies. The facility by which these controlled poly(MSAs) can be prepared via low-temperature RAFT without the need for functional group protection and the resulting pK(a)-dependent pH- and CO2-responsive properties point to significant potential in areas including drug and gene delivery and environmental remediation.
• US8978554B2
  申请人：——

  公开号：US8978554B2

  公开（公告）日：2015-03-17