Phenyl N-(2-hydroxyethyl)carbamate | 65935-01-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenyl N-(2-hydroxyethyl)carbamate
• CAS: 65935-01-5
• 化学式: C₉H₁₁NO₃
• mdl: MFCD00462428
• 分子量: 181.191
• InChiKey: ZGXHYTYJUGGTMG-UHFFFAOYSA-N

物化性质

• 沸点：
  304.9±34.0 °C(Predicted)
• 密度：
  1.208±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  DL-苯丙氨酸 、 Phenyl N-(2-hydroxyethyl)carbamate 在 甲烷磺酸 作用下， 以 甲苯 为溶剂， 100.0 ℃ 、80.0 kPa 条件下， 反应 8.0h， 以73%的产率得到2-(Phenoxycarbonylamino)ethyl 2-amino-3-phenylpropanoate
  参考文献：
  名称：

  METHOD FOR PRODUCING AMINO ACID AMINOALKYL ESTER OR INORGANIC ACID SALT THEREOF

  摘要：

  本发明提供了一种通过使下面显示的一般式（I）所代表的化合物或下面显示的一般式（III）所代表的化合物或其盐与下面显示的一般式（IV-I）所代表的化合物、下面显示的一般式（IV-II）所代表的化合物、下面显示的一般式（IV-III）所代表的化合物和下面显示的一般式（IV-IV）所代表的化合物或其无机酸盐中的至少一种化合物反应，从而制备氨基酸氨基醇酯或其无机酸盐的方法。

  公开号：

  US20210253517A1
• 作为产物：
  描述：

  碳酸二苯酯 、 C.I.酸性橙108 以 氯仿 为溶剂， 生成 Phenyl N-(2-hydroxyethyl)carbamate
  参考文献：
  名称：

  Catalyst-free amino-alcoholysis depolymerization strategy: a facile and powerful tool for chemical recycling of poly(bisphenol A carbonate)

  摘要：

  使用无催化剂的氨基醇解聚方法，对聚碳酸双酚A（BPA-PC）进行了化学升级回收。

  DOI：

  10.1039/d2gc03568e

文献信息

• Methods For Preparing Fluoroalkyl Arylsulfinyl Compounds And Fluorinated Compounds Thereto
  申请人：Umemoto Teruo

  公开号：US20110190511A1

  公开（公告）日：2011-08-04

  Novel preparative methods for fluoroalkyl arylsulfinyl compounds are disclosed. Fluorinated compounds as useful fluorinated compounds, intermediates, or builing blocks are disclosed. Useful applications of the fluoroalkyl arylsulfinyl compounds are shown.

  本发明揭示了一种用于制备氟烷基芳基亚磺酰化合物的新型制备方法。本发明还揭示了氟化合物作为有用的氟化合物、中间体或构建块。同时，本发明还展示了氟烷基芳基亚磺酰化合物的有用应用。
• Methods for Preparing Fluoroalkyl Arylsulfinyl Compounds and Fluorinated Compounds Thereto
  申请人：Umemoto Teruo

  公开号：US20100152463A1

  公开（公告）日：2010-06-17

  Novel preparative methods for fluoroalkyl arylsulfinyl compounds are disclosed. Fluorinated compounds as useful fluorinated compounds, intermediates, or building blocks are disclosed. Useful applications of the fluoroalkyl arylsulfinyl compounds are shown.

  本发明公开了用于制备氟烷基芳基磺酰基化合物的新型制备方法。本发明还公开了作为有用的氟化合物、中间体或构建块的氟化合物。本发明还展示了氟烷基芳基磺酰基化合物的有用应用。
• 1-Carbacephalosporin antibiotics
  申请人：ELI LILLY AND COMPANY

  公开号：EP0232623A1

  公开（公告）日：1987-08-19

  7β-Acylamino-3-alkoxycarbonyl-(and 3-keto)-1-carba (1-dethia)-3-cephem-4-carboxylic acids and derivatives and related 3-substituted compounds are provided as antibiotics useful for treating infections in man and other animals. Pharmaceutical formulations comprising the antibiotics, intermediates, and a process for their preparation are also provided.

  本发明提供了 7β-乙酰氨基-3-烷氧基羰基-（和 3-酮基）-1-咔巴（1-二硫杂）-3-头孢-4-羧酸及其衍生物和相关的 3-取代化合物，作为抗生素可用于治疗人类和其他动物的感染。此外，还提供了包含这些抗生素、中间体及其制备工艺的药物制剂。
• Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
  申请人：——

  公开号：US20040142857A1

  公开（公告）日：2004-07-22

  The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as cancer or viral infections.

  本发明提供了吉西他滨原药、制作吉西他滨原药的方法、吉西他滨原药的药物组合物以及使用吉西他滨原药及其药物组合物治疗或预防癌症或病毒感染等疾病或紊乱的方法。
• Aminolyses of 4-Nitrophenyl Phenyl Carbonate and Thionocarbonate:  Effect of Modification of Electrophilic Center from CO to CS on Reactivity and Mechanism
  作者：Ik-Hwan Um、Eun Young Kim、Hye-Ran Park、Sang-Eun Jeon

  DOI：10.1021/jo052417z

  日期：2006.3.1

  [GRAPHICS]A kinetic study is reported for nucleophilic substitution reactions of 4-nitrophenyl phenyl carbonate (5) and 4-nitrophenyl phenyl thionocarbonate (6) with a series of primary amines. The thiono compound 6 is less reactive than its oxygen analogue 5 toward strongly basic amines but is more reactive toward weakly basic CF3CH2NH2. The Bronsted-type plots obtained from the aminolyses of 5 and 6 are curved downwardly. The reactions are proposed to proceed through a stepwise mechanism with a change in the RDS on the basis of the curved Bronsted-type plots. The microscopic rate constants (k(1) and k(2)/k(-1) ratio) associated with the current aminolyses are consistent with the proposed reaction mechanism. The replacement of the C=O bond in 5 by a polarizable C=S group results in a decrease in the k(1) value but an increase in the k(2)/k(-1) ratio. Besides, such a modification of the electrophilic center causes a decrease in pK(a)degrees, defined as the pK(a) at the curvature center of curved Bronsted-type plots, but does not alter the reaction mechanism. The larger k(2)/k(-1) ratio for the reactions of 6 compared to those of 5 is proposed to be responsible for the decreased pK(a)degrees value.