diphenyl (4-(dimethylamino)phenylamino)(1-phenyl-3-(pyridin-2-yl)-1Hpyrazol-4-yl)methylphosphonate | 1401344-66-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: diphenyl (4-(dimethylamino)phenylamino)(1-phenyl-3-(pyridin-2-yl)-1Hpyrazol-4-yl)methylphosphonate
• 英文别名: 1-N-[diphenoxyphosphoryl-(1-phenyl-3-pyridin-2-ylpyrazol-4-yl)methyl]-4-N,4-N-dimethylbenzene-1,4-diamine
• CAS: 1401344-66-8
• 化学式: C₃₅H₃₂N₅O₃P
• 分子量: 601.645
• InChiKey: MRLZGENDSRAIDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  81.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  亚磷酸三苯酯 、 1-phenyl-3-pyridine-2-yl-1H-pyrazole-4-carboxaldehyde 、 N,N-二甲基-对苯二胺 在 lithium perchlorate 作用下， 以 二氯甲烷 为溶剂， 反应 0.2h， 以84%的产率得到diphenyl (4-(dimethylamino)phenylamino)(1-phenyl-3-(pyridin-2-yl)-1Hpyrazol-4-yl)methylphosphonate
  参考文献：
  名称：

  Synthesis and Antimicrobial Activities of Diphenyl(Arylamino)(1-Phenyl-3-(Pyridin-2-Yl)-1H-Pyrazol-4-Yl)Methylphosphonates

  摘要：

  A series of novel diphenyl(arylamino)(1-phenyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)methylphosphonates have been synthesized in high yields. They were screened for their antibacterial activities against Escherichia coli (NCIM2065) as a Gram-negative bacterium, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292) as Gram-positive bacteria, and Schccaromycies cerevisiae as a fungus. The minimum inhibitory concentrations (MICs) of the synthetic compounds showed moderate antibacterial and antifungal activities at low concentrations (10-1000 mu g/mL).

  DOI：

  10.1080/10426507.2012.690117