indoline-5-sulfonic acid | 98487-89-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: indoline-5-sulfonic acid
• 英文别名: 5-indolinesulfonic acid；5-Sulfo-indolin；2,3-dihydro-indole-5-sulfonic acid；2,3-dihydro-1H-indole-5-sulfonic acid
• CAS: 98487-89-9
• 化学式: C₈H₉NO₃S
• 分子量: 199.23
• InChiKey: PAIWTNHDWUIISN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  indoline-5-sulfonic acid 在 盐酸 、 五氯化磷 、 三氯氧磷 作用下， 以 水 为溶剂， 反应 15.0h， 生成 1-(4-octyl-1,3-thiazol-2-yl)indoline-5-sulfonyl chloride
  参考文献：
  名称：

  A Concise Synthesis of N‐(1,3‐Thiazol‐2‐yl) Indoline‐5‐Sulfonic Acids and Sulfonyl Chlorides

  摘要：

  A general and practical synthetic method was developed for indoline-5-sulfonic acids hearing a thiazole heterocycle attached to the nitrogen atom. Two select sulfonic acids were further converted to their corresponding sulfonyl chlorides, key intermediates to the indoline-5-sulfonamide pharmacophore.

  DOI：

  10.1081/scc-200034827

文献信息

• [EN] HYDROPHILIC, THIOL-REACTIVE CYANINE DYES AND CONJUGATES THEREOF WITH BIOMOLECULES FOR FLUORESCENCE DIAGNOSIS<br/>[FR] COLORANTS DE CYANINE THIOL-REACTIFS, HYDROPHILES ET PRODUITS CONJUGUES DE CEUX-CI AVEC DES BIOMOLECULES POUR PERMETTRE LE DIAGNOSTIC PAR FLUORESCENCE
  申请人：SCHERING AG

  公开号：WO2004065491A1

  公开（公告）日：2004-08-05

  This invention relates to new fluorescence dyes from the class of cyanine dyes, especially indotricarbocyanines with an absorption and fluorescence maximum in the spectral range of 700 to 900 nm, a thiol-specific reactive group, and three, preferably four, sulfonate groups, to an increase of water solubility as well as the production of dyes. This invention also relates to the conjugates of these dyes with biomolecules and uses thereof.

  本发明涉及一种新的荧光染料，属于青菁染料类，特别是吲哚三碳青菁染料，具有吸收和荧光最大值在700至900纳米波长范围内，具有硫醇特异性反应基团和三个，最好是四个，磺酸基团，以提高水溶性以及染料的生产。本发明还涉及这些染料与生物分子的结合物及其用途。
• HYDROPHILIC, THIOL-REACTIVE CYANINE DYES AND CONJUGATES THEREOF WITH BIOMOLECULES FOR FLUORESCENCE DIAGNOSIS
  申请人：Schering AG

  公开号：EP1585791A1

  公开（公告）日：2005-10-19
• CYANINE DYES CONJUGATED WITH ANTIBODIES FOR THE DIAGNOSIS OF MICROMETASTASIS
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP1784226A2

  公开（公告）日：2007-05-16
• USE OF BACTERIAL BETA-LACTAMASE FOR IN VITRO DIAGNOSTICS AND IN VIVO IMAGING, DIAGNOSTICS AND THERAPEUTICS
  申请人：Cirillo Jeffrey D.

  公开号：US20140127712A1

  公开（公告）日：2014-05-08

  Provided herein are assays and in vitro methods to determine susceptibility to a drug effective against a pathogenic bacteria, for example, a pathogenic Mycobacteria, that has a beta-lactamase activity. An excitation wavelength is delivered to a biological sample obtained from a subject having an infection from the pathogenic bacteria in the presence of a beta-lactamase substrate. The intensity of a signal, such as a fluorescent, luminescent or colorimetric signal, at an emission wavelength of a product of the beta-lactamase on the subject is correlated to drug susceptibility. Also provided is an assay system for monitoring drug susceptibility of a pathogenic bacteria comprising color-producing substrates for a beta-lactamase of the pathogenic bacteria, an assay device for visibly detecting a product of the beta-lactamase on the substrate thereof and a reader configured to quantify the visibly detected product.
• US4267251A
  申请人：——

  公开号：US4267251A

  公开（公告）日：1981-05-12