4-(1,3-oxathiolan-2-yl)benzaldehyde | 166768-62-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1,3-oxathiolan-2-yl)benzaldehyde
• CAS: 166768-62-3
• 化学式: C₁₀H₁₀O₂S
• 分子量: 194.254
• InChiKey: SDFMLSAMSJXOEY-UHFFFAOYSA-N

物化性质

• 沸点：
  365.0±42.0 °C(predicted)
• 密度：
  1.252±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(1,3-oxathiolan-2-yl)benzaldehyde 在 四丁基氟化铵 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 7.0h， 生成 2-<4-(1,3-oxathiolan-2-yl)benzylidene>cyclohexanone
  参考文献：
  名称：

  Synthesis ofO-methyloximes and nitrones of a series of substituted 4-[2-hydroxy-2-(1H-1,2,4-triazol-1-ylmethyl)cyclohexylidenemethyl]-benzaldehydes and their fungicidal activity

  摘要：

  O-Methyloximes and nitrones of a series of substituted 4-[2-hydroxy-2-(1H-1,2,4-triazol-1-ylmethyl)cyclohexylidenemethyl]benzaldehydes have been synthesized, and their fungicidal activity has been assayed. All of them exhibit low fungicidal activity in the in vitro assays and high activity in the in vivo assays; the O-methyl oximes are more active than the corresponding nitrones.

  DOI：

  10.1007/bf00698882
• 作为产物：
  描述：

  对苯二甲醛 、 2-巯基乙醇 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 反应 3.0h， 生成 4-(1,3-oxathiolan-2-yl)benzaldehyde
  参考文献：
  名称：

  具有高开启信号的高选择性双光子探针，用于对活细胞中的内源性HOCl进行成像

  摘要：

  次氯酸（HOCl）是典型的活性氧（ROS）之一，在免疫系统中起关键作用，并参与许多神经退行性疾病，例如缺血性中风，阿尔茨海默氏病和帕金森氏病。报道了一种用于检测HOCl的双光子探针，具有高选择性，快速响应（在30 s内），良好的穿透深度和低细胞毒性。在双光子激发下，探针对HOCl表现出显着的荧光“开启”响应。此外，该探针已成功地应用于监测活小胶质细胞BV-2细胞中脂多糖刺激的内源性HOCl。

  DOI：

  10.1016/j.dyepig.2017.07.006

文献信息

• Method for producing a hydroxyalkyl starch derivatives with two linkers
  申请人：Fresenius Kabi Deutschland GmbH

  公开号：EP2070951A1

  公开（公告）日：2009-06-17

  A method of producing a hydroxyalkyl starch (HAS) derivative, comprising a) reacting optionally oxidized hydroxyalkyl starch with a compound (D) comprising at least two functional groups -O-NH2 or a salt thereof, and b) reacting the hydroxyalkyl starch derivative obtained in step a) with a compound (L) comprising at least two functional groups W1 and W2 independently selected from the group consisting of an aldehyde group, a suitably protected aldehyde group, a keto group, and a suitably protected keto group.

  一种生产羟烷基淀粉（HAS）衍生物的方法，包括 a) 使任选氧化的羟烷基淀粉与包含至少两个官能团 -O-NH2 的化合物 (D) 或其盐反应，以及 b) 将步骤 a) 中得到的羟烷基淀粉衍生物与包含至少两个官能团 W1 和 W2 的化合物 （L）反应，这两个官能团独立地选自醛基、适当保护的醛基、酮基和适当保护的酮基组成的组。
• METHOD FOR PRODUCING A HYDROXYALKYL STARCH DERIVATIVE WITH TWO LINKERS
  申请人：Fresenius Kabi Deutschland GmbH

  公开号：EP2231710B1

  公开（公告）日：2012-06-20
• [EN] METHOD FOR PRODUCING A HYDROXYALKYL STARCH DERIVATIVE WITH TWO LINKERS<br/>[FR] PROCÉDÉ DE PRODUCTION D'UN DÉRIVÉ D'AMIDON HYDROXYALKYLÉ COMPORTANT DEUX SÉQUENCES DE LIAISON
  申请人：FRESENIUS KABI DE GMBH

  公开号：WO2009077153A1

  公开（公告）日：2009-06-25

  A method of producing a hydroxyalkyl starch (HAS) derivative, comprising a) reacting optionally oxidized hydroxyalkyl starch with a compound (D) comprising at least two functional groups -0-NH2 or a salt thereof, and b) reacting the hydroxyalkyl starch derivative obtained in step a) with a compound (L) comprising at least two functional groups W1 and W2 independently selected from the group consisting of an aldehyde group, a suitably protected aldehyde group, a keto group, and a suitably protected keto group.
• Synthesis ofO-methyloximes and nitrones of a series of substituted 4-[2-hydroxy-2-(1H-1,2,4-triazol-1-ylmethyl)cyclohexylidenemethyl]-benzaldehydes and their fungicidal activity
  作者：M. Z. Krimer、F. Z. Makaev、Yu. B. Kal'yan、V. P. Tashchi、Yu. G. Putsykin

  DOI：10.1007/bf00698882

  日期：1993.12

  O-Methyloximes and nitrones of a series of substituted 4-[2-hydroxy-2-(1H-1,2,4-triazol-1-ylmethyl)cyclohexylidenemethyl]benzaldehydes have been synthesized, and their fungicidal activity has been assayed. All of them exhibit low fungicidal activity in the in vitro assays and high activity in the in vivo assays; the O-methyl oximes are more active than the corresponding nitrones.
• A highly selective two-photon probe with large turn-on signal for imaging endogenous HOCl in living cells
  作者：Jingjing Cao、Dong-Ming Jiang、Xin Ren、Ting Li、Xiao-Ting Gong、Yong-Rui Yang、Zhu-Guo Xu、Chun-Lin Sun、Zi-Fa Shi、Shengxiang Zhang、Hao-Li Zhang

  DOI：10.1016/j.dyepig.2017.07.006

  日期：2017.11

  Hypochlorous acid (HOCl) is one of the typical reactive oxygen species (ROS), which plays a crucial role in the immune system, and is involved in many neurodegenerative disorders, such as ischemic stroke, Alzheimer's, and Parkinson's disease. A two-photon probe for sensing HOCl with high selectivity, fast response (within 30 s), good penetration depth and low cytotoxicity is reported. Under two-photon

  次氯酸（HOCl）是典型的活性氧（ROS）之一，在免疫系统中起关键作用，并参与许多神经退行性疾病，例如缺血性中风，阿尔茨海默氏病和帕金森氏病。报道了一种用于检测HOCl的双光子探针，具有高选择性，快速响应（在30 s内），良好的穿透深度和低细胞毒性。在双光子激发下，探针对HOCl表现出显着的荧光“开启”响应。此外，该探针已成功地应用于监测活小胶质细胞BV-2细胞中脂多糖刺激的内源性HOCl。