N-(3-chloropropyl)arachidonylamide | 220556-70-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(3-chloropropyl)arachidonylamide
• 英文别名: (5Z,8Z,11Z,14Z)-N-(3-Chloropropyl)-5,8,11,14-eicosatetraenamide；(5Z,8Z,11Z,14Z)-N-(3-chloropropyl)icosa-5,8,11,14-tetraenamide
• CAS: 220556-70-7
• 化学式: C₂₃H₃₈ClNO
• 分子量: 380.014
• InChiKey: QPBVZTQMIRREQE-DOFZRALJSA-N

物化性质

• 沸点：
  529.3±50.0 °C(Predicted)
• 密度：
  0.950±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  26
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  花生四烯酸 在 吡啶 、 草酰氯 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 1.5h， 生成 N-(3-chloropropyl)arachidonylamide
  参考文献：
  名称：

  Novel Analogues of Arachidonylethanolamide (Anandamide):  Affinities for the CB1 and CB2 Cannabinoid Receptors and Metabolic Stability

  摘要：

  Several analogues of the endogenous cannabinoid receptor ligand arachidonylethanolamide (anandamide) were synthesized and evaluated in order to study (a) the structural requirements for high-affinity binding to the CB1 and CB2 cannabinoid receptors and (b) their hydrolytic stability toward anandamide amidase. The series reported here was aimed at exploring structure-activity relationships (SAR) primarily with regard to stereoelectronic requirements of ethanolamido headgroup for interaction with the cannabinoid receptor active site. Receptor affinities, reported as K-i values, were obtained by a standard receptor binding assay using [H-3]CP-55,940 as the radioligand, while stability toward the amidase was evaluated by comparing the K-i of each analogue in the presence and absence of phenylmethanesulfonyl fluoride (PMSF), a serine protease blocker and inhibitor of anandamide amidase. Introduction of a methyl group in the 1'- and 2'-positions or substitution of the ethanolamido headgroup with a butylamido group gave analogues with vastly improved biochemical stability. This is accomplished in some cases with increased receptor affinity. Conversely, oxazolyl and methyloxazolyl headgroups led to low-affinity analogues. Substitution of the hydroxyl group with electronegative substituents such as fluoro, chloro, allyl, and propargyl groups significantly increased receptor affinity but did not influence the biochemical stability. The 2'-chloro analogue of anandamide was found to have the highest affinity for CB1. Additionally, reversing the positions of the carbonyl and NH in the amido group produces retro-anandamides possessing considerably higher metabolic stability. Replacement of the arachidonyl tail with oleyl or linoleyl results in analogues with low affinities for both receptors. All of the analogues in this study showed high selectivity for the CB1 receptor over the peripheral CB2 receptor. The most potent analogues were tested for their ability to stimulate the binding of [S-35]GTP gamma S to G-proteins and were shown to be potent cannabimimetic agonists. The results are discussed in terms of pharmacophoric features affecting receptor affinity and enzymatic stability.

  DOI：

  10.1021/jm970257g

文献信息

• CANNABIMIMETIC LIPID AMIDES AS USEFUL MEDICATIONS
  申请人：Makriyannis, Alexandros

  公开号：EP1049474A1

  公开（公告）日：2000-11-08
• EP1049474A4
  申请人：——

  公开号：EP1049474A4

  公开（公告）日：2004-12-29
• US7161016B1
  申请人：——

  公开号：US7161016B1

  公开（公告）日：2007-01-09
• [EN] CANNABIMIMETIC LIPID AMIDES AS USEFUL MEDICATIONS<br/>[FR] AMIDES LIPIDIQUES CANNABIMIMETIQUES S'UTILISANT COMME MEDICAMENTS
  申请人：MAKRIYANNIS ALEXANDROS

  公开号：WO2000032200A1

  公开（公告）日：2000-06-08

  Novel analogs of arachidonylethanolamide are presented which have higher affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and selectivity and/or greater metabolic stability make these analogs therapeutically useful as medications for relief of pain caused by cancer and nausea caused by chemotherapy, as well as for peripheral pain. The compounds may also be useful as oral and topical contraceptives, in suppression of the immune system, enhancement of appetite and in treatment of psychomotor disorders, multiple sclerosis and hypertension.