N-benzyl-1-[dimethoxy(oxido)phosphaniumyl]-1-(4-methylphenyl)methanamine | 1021190-24-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-1-[dimethoxy(oxido)phosphaniumyl]-1-(4-methylphenyl)methanamine
• CAS: 1021190-24-8
• 化学式: C₁₇H₂₂NO₃P
• 分子量: 319.34
• InChiKey: UGNJDYDHCWJDRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  53.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对甲基苯甲醛 、 亚磷酸二甲酯 、 苄胺 在 SbCl₃/Al₂O₃ 5A molecular sieve 作用下， 以 乙腈 为溶剂， 反应 4.5h， 以83%的产率得到N-benzyl-1-[dimethoxy(oxido)phosphaniumyl]-1-(4-methylphenyl)methanamine
  参考文献：
  名称：

  One-pot synthesis of α-aminophosphonates catalyzed by antimony trichloride adsorbed on alumina

  摘要：

  SbCl3 adsorbed on Al2O3 is found to be an efficient and recyclable catalyst in promoting three-component coupling reactions of aldehydes (aromatic and aliphatic), amines (aryl amines, aliphatic amines and esters of S-cc-amino acids) and dialkylphosphites to afford the corresponding alpha-aminophosphonates in high yields. The ethyl ester of S-phenylalanine was observed to yield the corresponding ot-aminophosphonate with S,S-diastereoisomer formed in dominance over the S,R-diastereoisomer. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.02.047

文献信息

• One-pot synthesis of α-aminophosphonates catalyzed by antimony trichloride adsorbed on alumina
  作者：Ambica、Satish Kumar、Subhash C. Taneja、Maninder S. Hundal、Kamal K. Kapoor

  DOI：10.1016/j.tetlet.2008.02.047

  日期：2008.3

  SbCl3 adsorbed on Al2O3 is found to be an efficient and recyclable catalyst in promoting three-component coupling reactions of aldehydes (aromatic and aliphatic), amines (aryl amines, aliphatic amines and esters of S-cc-amino acids) and dialkylphosphites to afford the corresponding alpha-aminophosphonates in high yields. The ethyl ester of S-phenylalanine was observed to yield the corresponding ot-aminophosphonate with S,S-diastereoisomer formed in dominance over the S,R-diastereoisomer. (C) 2008 Elsevier Ltd. All rights reserved.