ethyl-2-{1-[2-(piperidin-1-yl)ethyl]-1H-indol-3-yl} 2-oxoacetate | 1312545-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: ethyl-2-{1-[2-(piperidin-1-yl)ethyl]-1H-indol-3-yl} 2-oxoacetate
• 英文别名: ethyl-2-{1-[2-(piperidin-1-yl)ethyl]-1H-indol-3-yl}2-oxoacetate；ethyl 2-oxo-2-[1-(2-piperidin-1-ylethyl)indol-3-yl]acetate
• CAS: 1312545-44-0
• 化学式: C₁₉H₂₄N₂O₃
• 分子量: 328.411
• InChiKey: YZTWZYWQONJYLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  51.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(2-氯乙基)哌啶 、 2-氧代-3-吲哚羧酸乙酯 在 potassium carbonate 作用下， 以66%的产率得到ethyl-2-{1-[2-(piperidin-1-yl)ethyl]-1H-indol-3-yl} 2-oxoacetate
  参考文献：
  名称：

  3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma

  摘要：

  本发明涉及使用式(I)的化合物，其中R1和R3如描述中所定义，R2是带有2或3个C1-G6烷氧基取代的苯基，或其生理上可接受的盐，或式(I)的化合物或其盐的溶剂，用于治疗结肠或胃腺癌。

  公开号：

  EP2338486A1

文献信息

• [EN] 3-(INDOLYL)- OR 3-(AZAINDOLYL)-4-ARYLMALEIMIDE COMPOUNDS AND THEIR USE IN TUMOR TREATMENT<br/>[FR] COMPOSÉS DE 3-(INDOLYL) OU 3-(AZAINDOLYL)-4-ARYLMALÉIMIDE ET LEUR UTILISATION DANS LE TRAITEMENT DES TUMEURS
  申请人：UNIV MAINZ JOHANNES GUTENBERG

  公开号：WO2011073092A1

  公开（公告）日：2011-06-23

  The present invention relates to a compound of formula (I) wherein R1, R2 and R3 are as defined in the description and the physiologically acceptable salts thereof as well as the physiologically acceptable solvates of the compounds of formula I and of the salts thereof. The compounds of formula I are suitable for treating tumors.

  本发明涉及一种化合物，其化学式为（I），其中R1、R2和R3如描述中所定义，并且其生理上可接受的盐以及化合物（I）及其盐的生理上可接受的溶剂。化合物（I）适用于治疗肿瘤。
• 3-(INDOLYL)- OR 3-(AZAINDOLYL)- 4-ARYLMALEIMIDE DERIVATIVES FOR USE IN THE TREATMENT OF COLON AND GASTRIC ADENOCARZINOMA
  申请人：Dannhardt Gerd

  公开号：US20130029986A1

  公开（公告）日：2013-01-31

  The present invention relates to the use of a compound of formula (I) wherein R 1 and R 3 are as defined in the description and R 2 is a phenyl group which is substituted with 2 or 3 C 1 -C 6 alkoxy groups, or a physiologically acceptable salt thereof, or a solvate of the compound of formula (I) or of the salt thereof, for treatment of colorectal or gastric adenocarcinoma.

  本发明涉及使用式(I)的化合物，其中R1和R3如描述中所定义，而R2是一个苯基团，其被2或3个C1-C6烷氧基取代，或其生理上可接受的盐，或式(I)的化合物或其盐的溶剂，用于治疗结直肠或胃腺癌。
• 3-(INDOLYL)- OR 3-(AZAINDOLYL)- 4-ARYLMALEIMIDE COMPOUNDS AND THEIR USE IN TUMOR TREATMENT
  申请人：Dannhardt Gerd

  公开号：US20130131060A1

  公开（公告）日：2013-05-23

  The present invention relates to a compound of formula (I) wherein R 1 , R 2 and R 3 are as defined in the description and the physiologically acceptable salts thereof as well as the physiologically acceptable solvates of the compounds of formula I and of the salts thereof. The compounds of formula I are suitable for treating tumors.

  本发明涉及一种化合物(I)及其生理学上可接受的盐和溶剂，其中R1、R2和R3如描述中所定义。化合物I和其盐的生理学上可接受的溶剂适用于治疗肿瘤。
• 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
  申请人：Dannhardt Gerd

  公开号：US09012659B2

  公开（公告）日：2015-04-21

  The present invention relates to a compound of formula (I) wherein R1, R2 and R3 are as defined in the description and the physiologically acceptable salts thereof as well as the physiologically acceptable solvates of the compounds of formula I and of the salts thereof. The compounds of formula I are suitable for treating tumors.

  本发明涉及一种化合物，其化学式为（I），其中R1、R2和R3如描述中所定义，以及其在生理上可接受的盐和化合物的生理上可接受的溶剂，化合物的式子I和它们的盐的生理上可接受的溶剂，这些化合物适用于治疗肿瘤。
• 3-(indolyl)- or 3-(azaindolyl)- 4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma
  申请人：Dannhardt Gerd

  公开号：US09364459B2

  公开（公告）日：2016-06-14

  The present invention relates to the use of a compound of formula (I) wherein R1 and R3 are as defined in the description and R2 is a phenyl group which is substituted with 2 or 3 C1-C6 alkoxy groups, or a physiologically acceptable salt thereof, or a solvate of the compound of formula (I) or of the salt thereof, for treatment of colorectal or gastric adenocarcinoma.

  本发明涉及使用式(I)的化合物，其中R1和R3在描述中已定义，而R2是一个苯基团，其被2或3个C1-C6烷氧基取代，或其生理上可接受的盐，或式(I)的化合物或其盐的溶剂，用于治疗结直肠或胃腺癌。