decane-1,10-diyl bis(3-oxobutanoate) | 501426-98-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: decane-1,10-diyl bis(3-oxobutanoate)
• 英文别名: 10-(3-Oxobutanoyloxy)decyl 3-oxobutanoate
• CAS: 501426-98-8
• 化学式: C₁₈H₃₀O₆
• 分子量: 342.433
• InChiKey: GBJRXKDAEZOJHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  decane-1,10-diyl bis(3-oxobutanoate) 在 [Ru(2,6-Cl2tpp)CO] 对甲苯磺酰叠氮 、 三乙胺 作用下， 以 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 31.0h， 生成 (Z)-1,6-Dioxa-cyclohexadec-3-ene-2,5-dione
  参考文献：
  名称：

  Highly Selective Intra- and Intermolecular Coupling Reactions of Diazo Compounds to Form cis-Alkenes Using a Ruthenium Porphyrin Catalyst

  摘要：

  [Ru(2,6-Cl2TPP)(CO)] catalyzed intramolecular coupling reactions of bisdiazoacetates and intermolecular coupling reactions of monodiazoacetates to afford the coupling products in up to 76% and 93% yields, respectively. Only the cis isomers were obtained from the reactions. Employing such a ruthenium-catalyzed coupling reaction of a diazo compound as a key step allowed the synthesis of Patulolide B in 67% yield with a ratio of >40:1 against its trans isomer.

  DOI：

  10.1021/ol049626a
• 作为产物：
  描述：

  1,10-癸二醇 、 乙酰乙酸甲酯 在 碘 作用下， 以 甲苯 为溶剂， 反应 7.0h， 以79%的产率得到decane-1,10-diyl bis(3-oxobutanoate)
  参考文献：
  名称：

  碘催化β-酮酯酯交换的简单高效方法

  摘要：

  描述了一种使用催化碘进行的简单酯交换反应，适用于β-酮酯。

  DOI：

  10.1055/s-2003-42433

文献信息

• Multicomponent Combinatorial Polymerization via the Biginelli Reaction
  作者：Haodong Xue、Yuan Zhao、Haibo Wu、Zilin Wang、Bin Yang、Yen Wei、Zhiming Wang、Lei Tao

  DOI：10.1021/jacs.6b04425

  日期：2016.7.20

  A multicomponent combinatorial polymerization method has been exploited as a new intersection between combinatorial chemistry, polymer chemistry, and organic chemistry. The tricomponent Biginelli reaction has been employed as a model multicomponent reaction (MCR) to efficiently prepare a library of polycondensates with continuously changed chain structure but different physical properties. The naturally

  多组分组合聚合方法已被用作组合化学、聚合物化学和有机化学之间的新交叉点。三组分 Biginelli 反应已被用作模型多组分反应 (MCR)，以有效地制备具有不断变化的链结构但物理性质不同的缩聚物库。自然增加的反应模块（单体）直接使库中聚合物的数量增加了一倍，有效提高了聚合物制备的效率。首次绘制了这些同源聚合物的玻璃化转变温度 (Tg) 以预测不存在的聚合物同系物的 Tg 值，并且具有良好到出色的准确度。同时，Tg图还被用来揭示Tg根据聚合物结构（连接基团、单体链长等）的规律变化，初步表明了多组分组合聚合体系的学术意义。我们相信，当前的研究为通过 MCR 合成新的聚合物库铺平了道路，并可能促进跨学科领域对 MCR 的更广泛研究。
• Transesterification. I. β-Keto Esters
  作者：Alfred R. Bader、Lowell O. Cummings、Henry A. Vogel

  DOI：10.1021/ja01153a045

  日期：1951.9
• Zinc mediated transesterification of β-ketoesters and coumarin synthesis
  作者：Subhash P Chavan、K Shivasankar、R Sivappa、Ramesh Kale

  DOI：10.1016/s0040-4039(02)02006-3

  日期：2002.11

  The transesterification of ketoesters using zinc and iodine is described. The reaction has been done on a variety of alcohols and phenols. Alcohols furnish transesterified products whereas phenols gave 4-methylcoumarins. The method is highly promising compared with existing methods. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Inner Complexes. II. Macrocyclic Beryllium Chelates and their Polymers¹
  作者：Rudolph W. Kluiber、Joseph W. Lewis

  DOI：10.1021/ja01507a003

  日期：1960.11
• Efficient macrocyclization using methylene-tethered terminal dienes and bis(manganese(III)-enolate)s
  作者：Yosuke Ito、Tomomi Yoshinaga、Hiroshi Nishino

  DOI：10.1016/j.tet.2010.02.022

  日期：2010.4

  Macrocyclic compounds, which have two fused dihydrofuran rings, were synthesized with complete control by the oxidation of alpha,alpha,omega,omega-tetraaryl-alpha(omega-1)-alkadienes 1(x) with manganese(III)-oligomethylenebis(enolate) complexes directly formed by the reaction of the ohgomethylene bis(3-oxobutanoate)s 2(y) with manganese(III) acetate in situ The oxamethylene-tethered macrodiolides 5 and 7 were also produced in good to moderate yields by a similar oxidation The key intermediate, an election donor-acceptor-like complex, was proposed for the efficient macrocyclization reaction (C) 2010 Elsevier Ltd. All rights reserved