acryloyltryptophan | 59095-24-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acryloyltryptophan
• 英文别名: N-acryloyltriptophan；ATrp；3-(1H-indol-3-yl)-2-(prop-2-enoylamino)propanoic acid
• CAS: 59095-24-8
• 化学式: C₁₄H₁₄N₂O₃
• mdl: MFCD09935780
• 分子量: 258.277
• InChiKey: GYODWQURPCBMLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  82.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  DL-色氨酸 、 丙烯酰氯 生成 acryloyltryptophan
  参考文献：
  名称：

  Interaction of poly(N-acryloyl-amino acids) with saccharides in aqueous media

  摘要：

  The interaction of a series of poly(N-acryloyl-amino acids) (pAXaa) with saccharides has been investigated by (1)H NMR (1)H NMR for methyl-beta-D-galactopyranoside (M beta Gal) in the presence of pAXaa indicated that hydrophobic interaction or hydrogen bonding was not considerable in the interaction of the polymers with M beta Gal in aqueous media whereas CH-pi interaction was relatively important. (1)H NMR for several saccharides in the presence of poly(N-acryloyltryptophan) (pATrp) indicated that pATrp interacted more strongly with the beta-anomers than with the alpha-anomers presumably because of the triple CH-pi interactions of the three axial protons in the beta-anomers. In the interaction of pATrp with M beta Gal, M beta Gal interacted with two or more Trp residues because Trp residues were localized on the polymer chain. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2009.10.070

文献信息

• AMINO ACID-BASED POLYMERIZABLE COMPOUNDS AND OPHTHALMIC DEVICES PREPARED THEREFROM
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20210388142A1

  公开（公告）日：2021-12-16

  Provided are amino acid based polymerizable compounds and their applications in ophthalmic devices. The amino acid based polymerizable compounds are of formula I: wherein R, R 1 , and R 2 are as described herein.

  提供了基于氨基酸的可聚合化合物及其在眼科设备中的应用。该基于氨基酸的可聚合化合物的化学式为I：其中R，R1和R2如本文所述。
• Propenamide derivatives, polymers, copolymers and use thereof
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0488258B1

  公开（公告）日：1996-04-17
• US6046289A
  申请人：——

  公开号：US6046289A

  公开（公告）日：2000-04-04
• [EN] AMINO ACID-BASED POLYMERIZABLE COMPOUNDS AND OPHTHALMIC DEVICES PREPARED THEREFROM<br/>[FR] COMPOSÉS POLYMÉRISABLES À BASE D'ACIDES AMINÉS ET DISPOSITIFS OPHTALMIQUES PRÉPARÉS À PARTIR DE CEUX-CI
  申请人：JOHNSON & JOHNSON VISION CARE

  公开号：WO2021255552A1

  公开（公告）日：2021-12-23

  Provided are amino acid based polymerizable compounds and their applications in ophthalmic devices. The amino acid based polymerizable compounds are of formula I: wherein R, R1, and R2 are as described herein.
• Interaction of poly(N-acryloyl-amino acids) with saccharides in aqueous media
  作者：Akihito Hashidzume、Atsushi Tanaka、Takahiro Sato

  DOI：10.1016/j.polymer.2009.10.070

  日期：2010.1

  The interaction of a series of poly(N-acryloyl-amino acids) (pAXaa) with saccharides has been investigated by (1)H NMR (1)H NMR for methyl-beta-D-galactopyranoside (M beta Gal) in the presence of pAXaa indicated that hydrophobic interaction or hydrogen bonding was not considerable in the interaction of the polymers with M beta Gal in aqueous media whereas CH-pi interaction was relatively important. (1)H NMR for several saccharides in the presence of poly(N-acryloyltryptophan) (pATrp) indicated that pATrp interacted more strongly with the beta-anomers than with the alpha-anomers presumably because of the triple CH-pi interactions of the three axial protons in the beta-anomers. In the interaction of pATrp with M beta Gal, M beta Gal interacted with two or more Trp residues because Trp residues were localized on the polymer chain. (C) 2009 Elsevier Ltd. All rights reserved.