diethyl 2-ethoxysuccinate | 17596-10-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: diethyl 2-ethoxysuccinate
• 英文别名: diethyl ethoxysuccinate；ethoxysuccinic acid diethyl ester；O-Aethyl-DL-aepfelsaeure-diaethylester；Aethoxy-bernsteinsaeure-diaethylester；inakt.Aethoxy-bernsteinsaeure-diaethylester；Aethylaether-dl-aepfelsaeure-diaethylester；2-Ethoxy-succinic acid diethyl ester；diethyl 2-ethoxybutanedioate
• CAS: 17596-10-0
• 化学式: C₁₀H₁₈O₅
• 分子量: 218.25
• InChiKey: SYCKGYYABBRUOZ-UHFFFAOYSA-N

物化性质

• 沸点：
  92-93 °C(Press: 2 Torr)
• 密度：
  1.052±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  diethyl 2-ethoxysuccinate 在 sodium ethanolate 作用下， 以 丙酮 为溶剂， 反应 1.0h， 以57 g的产率得到3,5-二氧代环己烷羧酸乙酯
  参考文献：
  名称：

  调环酸钙和抗倒酯的合成方法

  摘要：

  本发明公开了一种调环酸钙和抗倒酯的合成方法。本发明将马来酸二乙酯(α，β不饱和羧酸酯)与乙醇钠反应得到高纯度的中间体式Ⅱ所示化合物，然后以式Ⅱ所示化合物作为原料即可制备得到调环酸钙和抗倒酯。制备式Ⅱ所示化合物的反应步骤中，其中乙醇钠是作为反应物参与的，并非作为强碱催化剂；中间体式Ⅱ所示化合物与丙酮在回流条件下得到1,3‑环己基二酮类化合物，两步反应的总收率高达87％。本发明方法以1,3‑环己基二酮类化合物为中间体，具有能耗低、反应时间短易操作等优点，可用于高收率制备调环酸钙和抗倒酯。

  公开号：

  CN107162907B
• 作为产物：
  描述：

  diethyl ethoxymaleate 在 镍 作用下， 30.0 ℃ 、7.35 MPa 条件下， 生成 diethyl 2-ethoxysuccinate
  参考文献：
  名称：

  Croxall; Schneider, Journal of the American Chemical Society, 1949, vol. 71, p. 1259

  摘要：

  DOI：

文献信息

• Enolate ion reactions of leucoquinizarin. Micheal additions
  作者：Gilles Arsenault、A. Douglas Broadbent、Peter Hutten-Czapski

  DOI：10.1039/c39830000437

  日期：——

  The base-catalysed reaction of leucoquinizarin with various Michael acceptors gives derivatives of potential value as anthracyclinone precursors.

  亮氨酸喹啉林与各种迈克尔受体的碱催化反应产生了潜在的衍生物，作为蒽环素酮前体。
• Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates their preparation and use
  申请人：——

  公开号：US20040198987A1

  公开（公告）日：2004-10-07

  This invention relates to a compound of Formula I, a method for its preparation and its use in the preparation of a compound of Formula II wherein R 1 , R 2 , R 3 , X and n are as defined in the disclosure. This invention also discloses preparation of compounds of Formula III wherein R 1 , R 2 , R 6 , R 7 , R 8 and n are as defined in the disclosure. Also disclosed are certain intermediates of Formula 4 for the preparation of compounds of Formula I wherein X is N and R 2 , R 3 and n are as defined in the disclosure. 1

  本发明涉及一种I式化合物，其制备方法及其在制备II式化合物中的应用，其中R1、R2、R3、X和n如本公开说明书所定义。本发明还揭示了制备III式化合物的方法，其中R1、R2、R6、R7、R8和n如本公开说明书所定义。还揭示了某些4式中间体，用于制备I式化合物，其中X为N，R2、R3和n如本公开说明书所定义。
• Subtituted dihydro 3-halo-1H-pyrazole-5-carboxylates their preparation and use
  申请人：Freudenberger Herbert John

  公开号：US20070203342A1

  公开（公告）日：2007-08-30

  This invention relates to a compound of Formula I, a method for its preparation and its use in the preparation of a compound of Formula II wherein R 1 , R 2 , R 3 , X and n are as defined in the disclosure. This invention also discloses preparation of compounds of Formula III wherein R 1 , R 2 , R 6 , R 7 , R 8 and n are as defined in the disclosure. Also disclosed are certain intermediates of Formula 4 for the preparation of compounds of Formula I wherein X is N and R 2 , R 3 and n are as defined in the disclosure.

  本发明涉及一种公式I的化合物，其制备方法以及在制备公式II的化合物中的使用，其中R1、R2、R3、X和n如本公开说明书中所定义。 本发明还揭示了公式III的化合物的制备方法，其中R1、R2、R6、R7、R8和n如本公开说明书中所定义。 还揭示了公式4的某些中间体，用于制备公式I的化合物，其中X为N，R2、R3和n如本公开说明书中所定义。
• NONAQUEOUS ELECTROLYTE SOLUTION AND ELECTROCHEMICAL ELEMENT USING SAME
  申请人：Abe Koji

  公开号：US20120171581A1

  公开（公告）日：2012-07-05

  Disclosed are a nonaqueous electrolytic solution of an electrolyte dissolved in a nonaqueous solvent, which contains a carboxylate represented by the following general formula (I) in an amount of from 0.01 to 10% by mass of the nonaqueous electrolytic solution; and an electrochemical element using it. (In the formula, R 1 represents an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, or a cyanoalkyl group; R 2 represents a hydrogen atom, an alkoxy group, a formyloxy group, an acyloxy group, an alkoxycarbonyloxy group, an alkanesulfonyloxy group, an arylsulfonyloxy group, an alkylsilyloxy group, a dialkylphosphoryloxy group, an alkoxy(alkyl)phosphoryloxy group, or a dialkoxyphosphoryloxy group; R 3 represents a hydrogen atom, —CH 2 COOR 6 , or an alkyl group; R 4 represents a hydrogen atom or an alkyl group; R 5 has the same meaning as R 2 , or represents a hydrogen atom, an alkyl group, or —CH 2 COOR 7 ; R 6 and R 7 each independently represent an alkyl group, an alkenyl group, an alkynyl group, or a cycloalkyl group; X represents —OR 8 , -A 2 -C≡Y 2 , -A 2 -C(═O)O-A 3 -C≡Y 2 , -A 2 -C(═O)O-A 4 or COOR 1 ; R 5 is the same as R 1 ; A 1 to A 3 each independently represent an alkylene group; A 4 represents an alkyl group; Y 2 represents CH or N; m indicates an integer of from 0 to 4; n indicates 0 or 1.)

  本发明涉及一种非水电解质溶液，其中包含以下述通式（I）表示的羧酸盐，其质量占非水电解质溶液的0.01至10％；以及使用该电解质溶液的电化学元件。（在式中，R1表示烷基、烯基、炔基、环烷基或氰基烷基；R2表示氢原子、烷氧基、甲酰氧基、酰氧基、烷氧羰基氧基、烷基磺酰氧基、芳基磺酰氧基、烷基硅氧基、二烷基磷酰氧基、烷氧（烷基）磷酰氧基或二烷氧基磷酰氧基；R3表示氢原子、-CH2COOR6或烷基；R4表示氢原子或烷基；R5与R2的含义相同，或表示氢原子、烷基或-CH2COOR7；R6和R7各自独立地表示烷基、烯基、炔基或环烷基；X表示-OR8，-A2-C≡Y2，-A2-C（═O）O-A3-C≡Y2，-A2-C（═O）O-A4或COOR1；R5与R1的含义相同；A1至A3各自独立地表示烷基；A4表示烷基；Y2表示CH或N；m表示0至4的整数；n表示0或1。）
• Process for the production of butyrolactone
  申请人：DAVY McKEE (LONDON) LIMITED

  公开号：EP0255400A1

  公开（公告）日：1988-02-03

  A process is described for the production of substantially pure gamma-butyrolactone from a feed mixture containing a major amount of gamma-butyrolactone and a minor amount of diethyl succinate which comprises fractionally distilling the mixture in a fractionation zone in the presence of added diethyl maleate and recovering from the fractionation zone an overhead vaporous product comprising gamma-butyrolactone which is substantially free from diethyl succinate and a liquid bottom product comprising diethyl maleate and diethyl succinate in admixture one with another. This procedure can be used to separate a gamma-butyrolactone rich fraction obtained by distillation in one or more stages of a crude reaction product obtained by hydrogenation of a C₄ dicarboxylic acid ester feedstock that contains a major molar amount of diethyl maleate and a minor molar amount of diethyl succinate, using a diethyl maleate feedstock from an esterification plant to provide both diethyl maleate for use in the fractionation zone and also diethyl maleate for use as feedstock for the hydrogenation process.

  描述了一种从含有大量γ-丁内酯和少量丁二酸二乙酯的进料混合物中生产基本纯的γ-丁内酯的工艺，该工艺包括在添加马来酸二乙酯的情况下，在分馏区对混合物进行分馏，并从分馏区回收由基本不含丁二酸二乙酯的γ-丁内酯组成的顶层蒸气产品和由马来酸二乙酯和丁二酸二乙酯相互混合组成的底层液体产品。丁内酯组成的顶层蒸发产物，其中基本上不含丁二酸二乙酯；以及由马来酸二乙酯和丁二酸二乙酯混合组成的底层液体产物。该步骤可用于分离富含γ-丁内酯的馏分，该馏分是通过对 C₄二羧酸酯原料进行氢化而得到的粗反应产物进行一个或多个阶段的蒸馏而得到的，该原料含有主要摩尔量的马来酸二乙酯和少量摩尔量的丁二酸二乙酯、使用来自酯化工厂的马来酸二乙酯原料，既提供马来酸二乙酯用于分馏区，也提供马来酸二乙酯用作氢化工艺的原料。