8-hydroxy-1-decen-6,9-dione | 82781-86-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-hydroxy-1-decen-6,9-dione
• 英文别名: 3-hydroxy-dec-9-ene-2,5-dione；3-Hydroxy-dec-9-en-2,5-dion；Decen-(1)-ol-(8)-dion-(6.9)；3-hydroxydec-9-ene-2,5-dione
• CAS: 82781-86-0
• 化学式: C₁₀H₁₆O₃
• 分子量: 184.235
• InChiKey: OVWMFHMKDUHZAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-hydroxy-1-decen-6,9-dione 在 sodium acetate 、 乙酸酐 作用下， 生成 deca-3,9-diene-2,5-dione
  参考文献：
  名称：

  Schechter; Green; La Forge, Journal of the American Chemical Society, 1949, vol. 71, p. 3168

  摘要：

  DOI：
• 作为产物：
  描述：

  6-硝基-1-己烯 在 acid Ti⁽³⁺⁾ 、 碳酸氢钠 、 对甲苯磺酸 、 三乙胺 、 锌 作用下， 以 甲醇 、 苯 为溶剂， 反应 3.0h， 生成 8-hydroxy-1-decen-6,9-dione
  参考文献：
  名称：

  Andersen, Soeren H.; Das, Nalin B.; Joergensen, Ruth D., Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1982, vol. 36, # 1, p. 1 - 14

  摘要：

  DOI：

文献信息

• Effects of 2% Ibopamine on Pupil, Refraction, Anterior Segment Anatomy and Intraocular Pressure
  作者：Giorgio Marchini、Silvia Babighian、Roberto Tosi、Sergio Perfetti、Luciano Bonomi

  DOI：10.1089/108076801750295254

  日期：2001.6

  The aim of the study was to determine the effects of a dopaminergic drug, 2% ibopamine, on the pupil, intraocular pressure and other ocular and ultrasound biometric variables.Thirty healthy subjects and 15 patients with primary open-angle glaucoma, aged from 40 to 78 years (mean age: 59.2 +/- 11), were included in two prospective open controlled trials. In the first, the mydriatic effect of 2% ibopamine and its inhibition and reversibility were evaluated in 15 healthy subjects using the alpha(1)-adrenergic drug, 0.5% dapiprazole. In the second, refraction, visual acuity, pupil diameter, intraocular pressure and 5 A-scan ultrasound biometric variables were evaluated in 15 healthy subjects and in 15 glaucoma patients.As early as forty min after administration of 2% ibopamine, a marked mydriatic ef feet (7.3 vs 3.9 mm; P < 0.0001), which was completely inhibited or reversed by 0.5% dapiprazole, was detected. The drug induced no changes in refraction, visual acuity or Ascan ultrasound biometric variables in any of the subjects examined. In healthy subjects, the intraocular pressure values were not changed to a statistically significant extent (13.8 vs 14.8 mm HE; P = 0.668), whereas a slight, though significant, hypertensive effect (24 vs 22.2 mm Hg, P = 0.002) was observed in the glaucoma patients.The study confirms the intense mydriatic effect of 2% ibopamine with no changes in refraction, visual acuity or A-scan ultrasound biometric variables, The drug has no effect on intraocular pressure in healthy subjects, but induces a significant hypertensive effect in patients with initial glaucoma. This characteristic could be used for early diagnosis of primary open-angle glaucoma.