1,3-Bis[(2-phenyl-1,3-dioxan-5-yl)oxy]propan-2-ol | 847682-11-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1,3-Bis[(2-phenyl-1,3-dioxan-5-yl)oxy]propan-2-ol
• CAS: 847682-11-5
• 化学式: C₂₃H₂₈O₇
• 分子量: 416.471
• InChiKey: FDBNVGFAAUZPJA-UHFFFAOYSA-N

物化性质

• 沸点：
  615.4±55.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1,3-Bis[(2-phenyl-1,3-dioxan-5-yl)oxy]propan-2-ol 在 吡啶 、 4-二甲氨基吡啶 、 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 5,5'-(2-azidopropane-1,3-diyl)bis(oxy)bis(2-phenyl-1,3-dioxane)
  参考文献：
  名称：

  Synthesis of Paclitaxel–BGL Conjugates

  摘要：

  Four kinds of symmetrically branched oligoglyceryl trimeric (BGL003)-paclitaxel conjugates and a corresponding heptameric (BGL007) conjugate were synthesized. Molecular weights of all the compounds were less than two times that of paclitaxel. The anti-tumor activity of the most water-soluble BGL003 conjugate was examined and found to be preserved in spite of the chemical modification that is displacement of the N3'-debenzoyl residue with the BGL003 succinyl residue. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.07.031

文献信息

• COMPOUND MODIFIED WITH GLYCEROL DERIVATIVE
  申请人：Nemoto Hisao

  公开号：US20100172967A1

  公开（公告）日：2010-07-08

  Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like. The present invention provides a compound in which a substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, is modified with a glycerol derivative represented by the following formula (1): wherein R represents a residue comprising a reactive group for the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance or for a spacer capable of binding the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, to R—X, or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: directly or via the spacer, or a salt thereof; a fine particle comprising the same; and the like.
• US7696359B2
  申请人：——

  公开号：US7696359B2

  公开（公告）日：2010-04-13
• Synthesis of Paclitaxel–BGL Conjugates
  作者：Hisao Nemoto、Ayato Katagiri、Masaki Kamiya、Tomoyuki Kawamura、Tsuyoshi Matsushita、Kosuke Matsumura、Tomohiro Itou、Hatsuhiko Hattori、Miho Tamaki、Keisuke Ishizawa、Licht Miyamoto、Shinji Abe、Koichiro Tsuchiya

  DOI：10.1016/j.bmc.2012.07.031

  日期：2012.9

  Four kinds of symmetrically branched oligoglyceryl trimeric (BGL003)-paclitaxel conjugates and a corresponding heptameric (BGL007) conjugate were synthesized. Molecular weights of all the compounds were less than two times that of paclitaxel. The anti-tumor activity of the most water-soluble BGL003 conjugate was examined and found to be preserved in spite of the chemical modification that is displacement of the N3'-debenzoyl residue with the BGL003 succinyl residue. (C) 2012 Elsevier Ltd. All rights reserved.