Boltorn H20 | 286831-93-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: Boltorn H20
• 英文别名: [3-[2-[3-[2-[3-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxy-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methylpropanoyl]oxyethoxy]-2,2-bis[2-[3-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxy-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methylpropanoyl]oxyethoxymethyl]propoxy]ethoxy]-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methyl-3-oxopropyl] 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate；[3-[2-[3-[2-[3-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxy-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methylpropanoyl]oxyethoxy]-2,2-bis[2-[3-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxy-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methylpropanoyl]oxyethoxymethyl]propoxy]ethoxy]-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methyl-3-oxopropyl] 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
• CAS: 286831-93-4
• 化学式: C₇₃H₁₂₄O₄₄
• 分子量: 1705.76
• InChiKey: WOMILJRHQMDYSM-UHFFFAOYSA-N

物化性质

• 沸点：
  1370.7±65.0 °C(Predicted)
• 密度：
  1.352±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -8.6
• 重原子数：
  117
• 可旋转键数：
  76
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  676
• 氢给体数：
  16
• 氢受体数：
  44

反应信息

• 作为反应物：
  描述：

  Boltorn H20 在 氯化亚砜 作用下， 以 1,4-二氧六环 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  基于Boltorn H20聚酯多元醇的新型带有末端阳离子基团的超支化树状大分子的合成

  摘要：

  摘要合成了超支化聚酯多元醇Boltorn H20的末端多氯化物。随后用无水吡啶或三苯基膦处理所得的多氯化物导致形成不同官能度的产物，在末端位置含有吡啶鎓或三苯基phenyl部分。

  DOI：

  10.1134/s1070363220040118

文献信息

• [EN] HYPERBRANCHED POLYMERS AND POLYPLEXES AND DNA OR RNA DELIVERY SYSTEMS INCLUDING THE SAME<br/>[FR] POLYMÈRES HYPER-RAMIFIÉS ET POLYPLEXES ET SYSTÈMES D'ADMINISTRATION D'ADN OU D'ARN EN COMPORTANT
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2016161345A1

  公开（公告）日：2016-10-06

  A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least three branches of the hyperbranched, hydrophobic molecular core, and respective polyethylene glycol chains attached to at least two other branches of the hyperbranched, hydrophobic molecular core. Examples of the hyperbranched polymer may be used to form hyperbranched polyplexes, and may be included in DNA or RNA delivery systems.

  一种超支化聚合物包括一个超支化、疏水性分子核，连接至该超支化、疏水性分子核至少三个支链的低分子量聚乙烯亚胺链，以及连接至该超支化、疏水性分子核至少两个其他支链的聚乙烯醇链。这种超支化聚合物的示例可用于形成超支化聚合物复合物，并可包含在DNA或RNA传递系统中。
• FT-IR characterization and hydrolysis of PLA-PEG-PLA based copolyester hydrogels with short PLA segments and a cytocompatibility study
  作者：David K. Wang、Srinivas Varanasi、Peter M. Fredericks、David J.T. Hill、Anne L. Symons、Andrew K. Whittaker、Firas Rasoul

  DOI：10.1002/pola.26930

  日期：2013.12.15

  rate of ester hydrolysis increased due to the increased concentration of the hydrolytically sensitive poly(lactic acid) (PLA) ester groups in the network. However, incorporation of Boltorn into the PLA‐PEG‐PLA copolymer did not significantly change the kinetic rate constant for hydrolysis of the PLA segments. The cytocompatibility of a typical one of these materials in the presence of its degradation

  使用氧化还原引发的聚合反应制备了一系列可生物降解的共聚酯水凝胶，其中Boltorn基丙烯酸酯和二丙烯酸三嵌段共聚单体的摩尔比恒定为1：9。Boltorn®大分子单体衍生自超支化聚酯Boltorn H20，其在每个末端均用聚丙烯酸乙二醇酯官能化，而二丙烯酸三嵌段大单体为聚丙交酯b乙二醇b-丙交酯）二丙烯酸酯。使用ATR-FTIR光谱研究了在37°C的磷酸盐缓冲盐溶液中pH 7.4时共聚酯的水解。结果发现，Boltorn，PEG和丙交酯嵌段的长度在确定这些材料的结构-性质关系中都起着至关重要的作用。ATR-FTIR研究表明，随着丙交酯链段长度的增加，由于网络中水解敏感的聚乳酸（PLA）酯基团的浓度增加，酯的水解速率也增加了。但是，将Boltorn掺入PLA-PEG-PLA共聚物中并不会显着改变PLA链段水解的动力学速率常数。使用大鼠培养的成骨细胞评估了其中一种典型材料在降解副产物存在下的细胞相
• Peptide-based multimeric targeted contrast agents
  申请人：Zhang Zhaoda

  公开号：US20060039861A1

  公开（公告）日：2006-02-23

  Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.

  本文描述了肽和肽靶向多聚对比剂，以及制备和使用对比剂的方法。
• Fluorinated modification of hyperbranched polyesters used for improving the surface property of UV curing coatings
  作者：Hui Miao、Fenfen Bao、Liangliang Cheng、Wenfang Shi

  DOI：10.1016/j.jfluchem.2010.09.008

  日期：2010.12

  The commercial hyperbranched aliphatic polyols (Hn) were modified by thioglycolic acid (TA) and hexafluorobutyl acrylate (HFBA) or dodecafluoroheptyl methacrylate (DFHMA) to prepare a series of fluorinated hyperbranched polyesters. For comparison, a linear fluorinated polymer, poly(n-BMA-co-DFHMA), was synthesized through the copolymerization of n-butyl methacrylate (BMA) and DFHMA. The molecular structures were characterized by H-1 NMR spectroscopic analysis. The synthesized polymers were incorporated into UV-curable formulations as additives, and exposed to a UV lamp. After UV curing, the wettability of the films was investigated by contact angle measurement with water and bromonaphthalene. The results showed that both the hydrophobicity and oleophobicity were greatly enhanced. Moreover, the fluorinated hyperbranched polymers possessed better water and oil repellency than the copolymer poly(n-BMA-co-DFHMA) at a very low concentration. The surface F/C ratio values of the cured films were detected by XPS analysis, and the film with TAH20-DFHMA showed the highest F/C ratio value, indicating its most efficient aggregation effect at the film surface. (C) 2010 Elsevier B.V. All rights reserved.
• Dendritic High-molecular-weight Polymer Drug Carriers and Their Conjugates with Drugs Especially for Treatment of Solid Tumours
  申请人：Etrych Tomas

  公开号：US20120296048A1

  公开（公告）日：2012-11-22

  The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.