α-phenyl-N-(4-biphenyl)nitrone | 866999-39-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-phenyl-N-(4-biphenyl)nitrone
• 英文别名: 1-phenyl-N-(4-phenylphenyl)methanimine oxide
• CAS: 866999-39-5；94664-78-5
• 化学式: C₁₉H₁₅NO
• 分子量: 273.334
• InChiKey: CIYQFAVFVSVJIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.61
• 重原子数：
  21.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  α-phenyl-N-(4-biphenyl)nitrone 在 sodium carbonate 作用下， 以 甲醇 、 乙醇 、 苯 为溶剂， 反应 12.17h， 生成 8-((1,1'-联苯)-4-基氨基)-2'-脱氧鸟苷
  参考文献：
  名称：

  SYNTHESIS AND CHARACTERIZATION OF NUCLEOSIDE DERIVATIVES,N-(BENZOYL)-N-(DEOXYGUANOSIN-8-YL)-4-AMINOBIPHENYL ANDN-(2′-DEOXYGUANOSIN-8-YL)-4-AMINOBIPHENYL VIA α-PHENYL-N-(4-BIPHENYL)NITRONE

  摘要：

  Lead tetraacetate (LTA) oxidation of alpha-Phenyl-N-(4-biphenyl)nitrone (8) to give a new ultimate carcinogen, N-acetoxy-N-benzoyl-4-aminobiphenyl (9) which was reacted with deoxyguanosine (dG) at pH 6.9 to give nucleoside derivative, N-(benzoyl)-N-(deoxyguanosin-8-yl)-4-aminobiphenyl (10). Following debenzoylation with sodium carbonate-methanol leads to N-(2'-deoxyguanosin-8-yl)-4-aminobiphenyl (11).

  DOI：

  10.1081/ncn-120006832
• 作为产物：
  描述：

  硝基联苯 在 氯化铵 、 D,L-histidine 、 锌 作用下， 以 乙醚 、 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.5h， 生成 α-phenyl-N-(4-biphenyl)nitrone
  参考文献：
  名称：

  SYNTHESIS AND CHARACTERIZATION OF NUCLEOSIDE DERIVATIVES,N-(BENZOYL)-N-(DEOXYGUANOSIN-8-YL)-4-AMINOBIPHENYL ANDN-(2′-DEOXYGUANOSIN-8-YL)-4-AMINOBIPHENYL VIA α-PHENYL-N-(4-BIPHENYL)NITRONE

  摘要：

  Lead tetraacetate (LTA) oxidation of alpha-Phenyl-N-(4-biphenyl)nitrone (8) to give a new ultimate carcinogen, N-acetoxy-N-benzoyl-4-aminobiphenyl (9) which was reacted with deoxyguanosine (dG) at pH 6.9 to give nucleoside derivative, N-(benzoyl)-N-(deoxyguanosin-8-yl)-4-aminobiphenyl (10). Following debenzoylation with sodium carbonate-methanol leads to N-(2'-deoxyguanosin-8-yl)-4-aminobiphenyl (11).

  DOI：

  10.1081/ncn-120006832

文献信息

• SYNTHESIS AND CHARACTERIZATION OF NUCLEOSIDE DERIVATIVES,<i>N</i>-(BENZOYL)-<i>N</i>-(DEOXYGUANOSIN-8-YL)-4-AMINOBIPHENYL AND<i>N</i>-(2′-DEOXYGUANOSIN-8-YL)-4-AMINOBIPHENYL VIA α-PHENYL-<i>N</i>-(4-BIPHENYL)NITRONE
  作者：H. Mallesha、K. R. Ravi Kumar、K. S. Rangappa

  DOI：10.1081/ncn-120006832

  日期：2002.7

  Lead tetraacetate (LTA) oxidation of alpha-Phenyl-N-(4-biphenyl)nitrone (8) to give a new ultimate carcinogen, N-acetoxy-N-benzoyl-4-aminobiphenyl (9) which was reacted with deoxyguanosine (dG) at pH 6.9 to give nucleoside derivative, N-(benzoyl)-N-(deoxyguanosin-8-yl)-4-aminobiphenyl (10). Following debenzoylation with sodium carbonate-methanol leads to N-(2'-deoxyguanosin-8-yl)-4-aminobiphenyl (11).