2-hydroxy-4'-chloro-4-methylbenzophenone | 107622-28-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-4'-chloro-4-methylbenzophenone
• 英文别名: 4'-Chlor-2-hydroxy-4-methyl-benzophenon；4'-chloro-2-hydroxy-4-methyl-benzophenone；(4-Chlorophenyl)(2-hydroxy-4-methylphenyl)methanone；(4-chlorophenyl)-(2-hydroxy-4-methylphenyl)methanone
• CAS: 107622-28-6
• 化学式: C₁₄H₁₁ClO₂
• 分子量: 246.693
• InChiKey: GYVFYXJLIDHYMG-UHFFFAOYSA-N

物化性质

• 熔点：
  83–84°C
• 沸点：
  381.1±32.0 °C(Predicted)
• 密度：
  1.270±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxy-4'-chloro-4-methylbenzophenone 在 sodium 、 一水合肼 、 二乙二醇 作用下， 生成 2-(4-chloro-benzyl)-5-methyl-phenol
  参考文献：
  名称：

  Malik; Saharia, Journal Of Scientific and Industrial Research, 1956, vol. 15 B, p. 633

  摘要：

  DOI：
• 作为产物：
  描述：

  4-chloro-benzoic acid m-tolyl ester 在 三氯化铝 作用下， 生成 2-hydroxy-4'-chloro-4-methylbenzophenone
  参考文献：
  名称：

  Malik; Saharia, Journal Of Scientific and Industrial Research, 1956, vol. 15 B, p. 633

  摘要：

  DOI：

文献信息

• Direct Acylation of Phenol and Naphthol Derivatives in a Mixture of Graphite and Methanesulfonic Acid
  作者：Hashem Sharghi、Mona Hosseini-Sarvari、Razieh Eskandari

  DOI：10.1055/s-2006-942384

  日期：2006.6

  Graphite in methanesulfonic acid is used to prepare o-hydroxyketones by direct acylation of phenol and naphthol derivatives with carboxylic acids.

  甲磺酸中的石墨用于通过苯酚和萘酚衍生物与羧酸的直接酰化来制备邻羟基酮。
• Chiral Phosphoric Acid Catalyzed Enantioselective Transfer Hydrogenation of ortho-Hydroxybenzophenone NH Ketimines and Applications
  作者：Thanh Binh Nguyen、Qian Wang、Françoise Guéritte

  DOI：10.1002/chem.201101694

  日期：2011.8.22

  Unprotected synthesis: The first enantioselective chiral phosphoric acid catalyzed transfer hydrogenation of unprotected ortho‐hydroxybenzophenone NH imines by using a Hantzsch ester as the hydrogen source afforded the corresponding chiral N,O‐unprotected ortho‐hydroxydiarylmethylamines in high yields with excellent enantioselectivities (see scheme).

  未受保护的合成：第一对映选择性的手性磷酸催化的传递未受保护的氢化邻-hydroxybenzophenoneÑ  ħ亚胺通过使用汉奇酯作为得到相应的手性氢源N，O -unprotected邻-hydroxydiarylmethylamines以高收率和优异的对映选择性（见方案）。
• Phosphoric Acid-Catalyzed Enantioselective Transfer Hydrogenation of N-Aryl-ortho-Hydroxybenzophenone Ketimines
  作者：Thanh Binh Nguyen、Hadjira Bousserouel、Qian Wang、Françoise Guéritte

  DOI：10.1002/adsc.201000754

  日期：2011.2.11

  The first enantioselective chiral phosphoric acid-catalyzed transfer hydrogenation of N-aryl-ortho-hydroxybenzophenone ketimines using a Hantzsch ester as hydrogen source was developed to afford, after removal of the N-aryl group, the corresponding chiral diarylmethylamines in high yields and enantioselectivities.

  第一对映选择性的手性磷酸催化的转移氢化ñ -芳基-邻-hydroxybenzophenone酮亚胺使用汉奇酯作为氢源的开发是为了得到，在除去后Ñ -芳基，以高收率和对映选择性的相应的手性diarylmethylamines。
• Cellulose Acylate Film, Method of Producing the Same, Cellulose Derivative Film, Optically Compensatory Film Using the Same, Optically-Compensatory Film Incorporating Polarizing Plate, Polarizing Plate and Liquid Crystal Display Device
  申请人：Haruta Hiromoto

  公开号：US20090290100A1

  公开（公告）日：2009-11-26

  A method of producing a cellulose derivative film, the method comprising: forming a film with a solvent cast method from a dope including a cellulose derivative satisfying following conditions (a) and (b): (a) at least one among three hydroxyl groups included in a glucose unit of cellulose is substituted by a substituent of which a polarizability anisotropy Δα represented as following Expression (1) is 2.5×10 −24 cm 3 or higher: Expression (1): Δα=αx−(αy+αz)/2, wherein αx, αy and αz is as defined in the specification; and (b) when a substitution degree by a substituent of which Δα is 2.5×10 −24 cm 3 or higher is P A , and a substitution degree by a substituent of which Δα is lower than 2.5×10 −24 cm 3 is P B , the P A and P B satisfy following Expressions (3) and (4): Expression (3): 2P A +P B >3.0; and Expression (4): P A >0.2.

  一种生产纤维素衍生物薄膜的方法，该方法包括：使用包括满足以下条件（a）和（b）的纤维素衍生物的溶胶，通过溶剂浇铸法形成薄膜：（a）纤维素的葡萄糖单元中的三个羟基中的至少一个被取代为极化率各向异性Δα（以下表达式（1）表示）为2.5×10-24cm3或更高的取代基：表达式（1）：Δα=αx-（αy+αz）/ 2，其中αx，αy和αz如规范中定义的；并且（b）当Δα为2.5×10-24cm3或更高的取代基的取代度为PA时，Δα低于2.5×10-24cm3的取代基的取代度为PB，PA和PB满足以下表达式（3）和（4）：表达式（3）：2PA + PB> 3.0；表达式（4）：PA> 0.2。
• Sharghi, Hashem; Kaboudin, Babak, Journal of Chemical Research, Miniprint, 1998, # 10, p. 2678 - 2695
  作者：Sharghi, Hashem、Kaboudin, Babak

  DOI：——

  日期：——