1-Carbomethoxy-2,3-dihydro-2,3'-diindole | 94512-22-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-Carbomethoxy-2,3-dihydro-2,3'-diindole
• 英文别名: N-methoxycarbonyl-2-(3'-indolyl)indoline；methyl 2-(1H-indol-3-yl)-2,3-dihydroindole-1-carboxylate
• CAS: 94512-22-8
• 化学式: C₁₈H₁₆N₂O₂
• 分子量: 292.337
• InChiKey: HMQIEGXKOCDFIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  45.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吲哚 在 barium dihydroxide 作用下， 以 苯 为溶剂， 反应 4.0h， 生成 1-Carbomethoxy-2,3-dihydro-2,3'-diindole
  参考文献：
  名称：

  Husain, Mashkoor; Husain, Mubarak; Khan, Naseem H., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 10, p. 986 - 988

  摘要：

  DOI：

文献信息

• Synthesis of Indolylindolines Mediated by tert-BuNH2
  作者：Oscar R. Suárez-Castillo、Ana L. Morales-García、Indira C. Cano-Escudero、Yaneth M. A. Contreras-Martínez、Myriam Meléndez-Rodríguez、Martha S. Morales-Ríos、Pedro Joseph-Nathan

  DOI：10.3987/com-08-11627

  日期：——

  An improved synthesis of N1-carbomethoxylated indolylindolines 2 from 5-substituted indoles 1, by replacing the previously employed strong acids or toxic metals with t-BuNH2/MeOCOCl in CH2Cl2/H2O, is described. The substituent effect of electron donor or acceptor groups was examined, revealing that electron-deficient indoles are less reactive to dimerization than electron-rich indoles, with 5-cyano and 5-nitroindoles leading to no reaction. A dynamic process caused by the restricted rotation of the N-CO2Me bond of 2 was evidenced by H-1 NMR measurements.
• HUSAIN, MASHKOOR;HUSAIN, MUBARAK;KHAN, NASEEM, H., INDIAN J. CHEM., 1984, 23, N 10, 986-988
  作者：HUSAIN, MASHKOOR、HUSAIN, MUBARAK、KHAN, NASEEM, H.

  DOI：——

  日期：——
• Husain, Mashkoor; Husain, Mubarak; Khan, Naseem H., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 10, p. 986 - 988
  作者：Husain, Mashkoor、Husain, Mubarak、Khan, Naseem H.

  DOI：——

  日期：——