2-fluoroethyl formate | 462-76-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-fluoroethyl formate
• 英文别名: formic acid-(2-fluoro-ethyl ester)；Ameisensaeure-(2-fluor-aethylester)
• CAS: 462-76-0
• 化学式: C₃H₅FO₂
• 分子量: 92.0699
• InChiKey: MMNDXBQCAKGDMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  6
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2915120000

反应信息

• 作为反应物：
  描述：

  3-((5-chlorobenzo[d]thiazol-2-yl)methoxy)-2,6-difluorobenzamide 、 2-fluoroethyl formate 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 3.0h， 以49%的产率得到2-Fluoroethyl N-[3-[(5-chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluorobenzoyl]carbamate
  参考文献：
  名称：

  ANTIMICROBIAL AGENTS

  摘要：

  该发明提供了式(I)的化合物： 其中R1-R3，n和W具有规范中定义的任何值，并且其盐。这些化合物具有良好的溶解性，可用于治疗细菌感染。

  公开号：

  US20150133465A1
• 作为产物：
  描述：

  甲酸 、 2-氟乙醇 在 乙醚 、 水 、 copper(II) sulfate 作用下， 生成 2-fluoroethyl formate
  参考文献：
  名称：

  Cross-Cultural Perspectives: Implications for Attachment Theory and Family Therapy

  摘要：

  Cross‐cultural perspectives have always been useful for understanding behavior. They clarify the distinction between aspects that are essentially part of the human condition and those that are the most responsive to variation. The interesting article by Rothbaum and his colleagues is in that tradition, contrasting the cultural values and family patterns in Japanese society with those of Western cultures, including our own, and suggesting that these differences shape the nature and course of attachment. It stimulates questions about what we have taken for granted in our theories and in our evaluations of dysfunctional behavior.

  DOI：

  10.1111/j.1545-5300.2002.41316.x

文献信息

• Pd-Catalyzed Regioselective Hydroesterification of Olefins with 2,2,2-Trifluoroethyl Formate
  作者：Jinhua Chen、Minyan Huang、Wenlong Ren、Jianxiao Chu、Yian Shi

  DOI：10.1002/ejoc.201901601

  日期：2020.3.8

  A Pd‐catalyzed regioselective hydroesterification of olefins with 2,2,2‐trifluoroethyl formate (TFEF) is described. Either linear or branched esters can be selectively obtained with proper ligands in most cases. The reaction process is operationally simple and involves no toxic CO gas.

  描述了钯与2,2,2-三氟乙基甲酸（TFEF）的Pd催化的区域选择性加氢酯化。在大多数情况下，可以通过适当的配体选择性地获得直链或支链酯。该反应过程操作简单，不涉及有毒的CO气体。
• ANTIMICROBIAL AGENTS
  申请人：Rutgers, The State University of New Jersey

  公开号：US20150133465A1

  公开（公告）日：2015-05-14

  The invention provides compounds of formula (I): wherein R 1 -R 3 , n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.

  该发明提供了式(I)的化合物： 其中R1-R3，n和W具有规范中定义的任何值，并且其盐。这些化合物具有良好的溶解性，可用于治疗细菌感染。
• Cross-Cultural Perspectives: Implications for Attachment Theory and Family Therapy
  作者：Patricia Minuchin

  DOI：10.1111/j.1545-5300.2002.41316.x

  日期：2002.9

  Cross‐cultural perspectives have always been useful for understanding behavior. They clarify the distinction between aspects that are essentially part of the human condition and those that are the most responsive to variation. The interesting article by Rothbaum and his colleagues is in that tradition, contrasting the cultural values and family patterns in Japanese society with those of Western cultures, including our own, and suggesting that these differences shape the nature and course of attachment. It stimulates questions about what we have taken for granted in our theories and in our evaluations of dysfunctional behavior.