4-(6-nitro-1H-indol-3-yl)butan-2-one | 1335106-53-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-(6-nitro-1H-indol-3-yl)butan-2-one
• CAS: 1335106-53-0
• 化学式: C₁₂H₁₂N₂O₃
• 分子量: 232.239
• InChiKey: OOLPDOBFZPHFKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  78.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-硝基吲哚 、 丁烯酮 在 graphite oxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 6.5h， 以77%的产率得到4-(6-nitro-1H-indol-3-yl)butan-2-one
  参考文献：
  名称：

  Recyclable graphite oxide catalyzed Friedel–Crafts addition of indoles to α,β-unsaturated ketones

  摘要：

  The Friedel-Crafts addition of indoles to alpha,beta-unsaturated ketones, and nitro styrenes was studied with graphite oxide as catalyst. Various indole derivatives were synthesized in good to excellent yields. The preparation of graphite oxide catalyst from simple and readily available starting materials makes this method more affordable. The heterogeneous graphite oxide can be easily recovered and recycled up to five cycles without loss of activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.002

文献信息

• Recyclable graphite oxide catalyzed Friedel–Crafts addition of indoles to α,β-unsaturated ketones
  作者：A. Vijay Kumar、K. Rama Rao

  DOI：10.1016/j.tetlet.2011.08.002

  日期：2011.10

  The Friedel-Crafts addition of indoles to alpha,beta-unsaturated ketones, and nitro styrenes was studied with graphite oxide as catalyst. Various indole derivatives were synthesized in good to excellent yields. The preparation of graphite oxide catalyst from simple and readily available starting materials makes this method more affordable. The heterogeneous graphite oxide can be easily recovered and recycled up to five cycles without loss of activity. (C) 2011 Elsevier Ltd. All rights reserved.