6-(methylamino)hexanoic acid hydrochloride | 121912-30-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(methylamino)hexanoic acid hydrochloride
• 英文别名: Hydron;6-(methylamino)hexanoic acid;chloride；hydron;6-(methylamino)hexanoic acid;chloride
• CAS: 121912-30-9
• 化学式: C₇H₁₅NO₂*ClH
• 分子量: 181.663
• InChiKey: AILMWCOKRFHBHG-UHFFFAOYSA-N

物化性质

• 熔点：
  66-67 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -3.17
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  53.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(methylamino)hexanoic acid hydrochloride 在 三乙胺 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 、 sodium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.66h， 生成
  参考文献：
  名称：

  N-Acetylgalactosamino Dendrons as Clearing Agents to Enhance Liver Targeting of Model Antibody-Fusion Protein

  摘要：

  Dendrimer clearing agents represent a unique class of compounds for use in multistep targeting (MST) in radioimmunotherapy and imaging. These compounds were developed to facilitate the removal of excess tumor-targeting monoclonal antibody (mAb) prior to administration of the radionuclide to minimize exposure of normal tissue to radiation. Clearing agents are designed to capture the circulating mAb, and target it to the liver for metabolism. Glycodendrons are ideally suited for MST applications as these highly branched compounds are chemically well-defined, thus advantageous over heterogeneous macromolecules. Previous studies have described glycodendron 3 as a clearing agent for use in three-step MST protocols, and early in vivo assessment of 3 showed promise. However, synthetic challenges have hampered its availability for further development. In this report we describe a new sequence of chemical steps which enables the straightforward synthesis and analytical characterization of this class of dendrons. With accessibility and analytical identification solved, we sought to evaluate both lower and higher generation dendrons for hepatocyte targeting as well as clearance of a model protein. We prepared a series of clearing agents where a single biotin is connected to glycodendrons displaying four, eight, sixteen or thirty-two alpha-thio-N-acetylgalactosamine (alpha-SGalNAc) units, resulting in compounds with molecular weights ranging from 2 to 17 kDa, respectively. These compounds were fully characterized by LCMS and NMR. We then evaluated the capacity of these agents to clear a model I-131-labeled single chain variable fragment antibody-streptavidin (I-131-scFv-SAv) fusion protein from blood and tissue in mice, and compared their clearing efficiencies to that of a 500 kDa dextran-biotin conjugate. Glycodendrons and dextran-biotin exhibited enhanced blood clearance of the scFv-SAv construct. Biodistribution analysis showed liver targeting/uptake of the scFv-SAv construct to be 2-fold higher for compounds 1 to 4, as well as for the 500 kDa dextran, over saline. Additionally, the data suggest the glycodendrons clear through the liver, whereas the dextran through reticuloendothelial system (RES) metabolism.

  DOI：

  10.1021/bc400333m
• 作为产物：
  描述：

  N-甲基己内酰胺 在 盐酸 作用下， 以 水 为溶剂， 以77 %的产率得到6-(methylamino)hexanoic acid hydrochloride
  参考文献：
  名称：

  附在荧光团上的通用光激活标签使其可用于单分子成像

  摘要：

  我们开发了一种通过在荧光分子上引入通用标签 SO 来构建可光激活探针的通用策略。该策略适用于大多数具有各种骨架结构的商业荧光团。我们成功地将这些光敏探针应用于活细胞中的延时超分辨率跟踪和固定神经元微管的超分辨率成像。

  DOI：

  10.1002/anie.202211767

文献信息

• [EN] BIOMOLECULE CONJUGATES<br/>[FR] CONJUGUÉS DE BIOMOLÉCULE
  申请人：CELGENE CORP

  公开号：WO2016090157A1

  公开（公告）日：2016-06-09

  The present invention relates to biomolecule conjugates which comprise a biomolecule wherein at least one non-natural amino acid (NNAA) is integral to the structure of the biomolecule and wherein the NNAA is a point of attachment of a linker to which a payload, particularly a cytotoxic agent, is attached. More specifically, this invention relates to conjugates of cell-binding agents and active release products comprising cytotoxic agents wherein the conjugates are produced by means of a cycloaddition reaction. Methods of production, pharmaceutical compositions and methods of use are provided.

  本发明涉及生物分子共轭物，其包括一种生物分子，其中至少有一种非天然氨基酸（NNAA）构成生物分子的结构，并且NNAA是连接物的附着点，连接物上附着有一种荷载物，特别是细胞毒性药剂。更具体地说，本发明涉及细胞结合剂和活性释放产物的共轭物，其中共轭物是通过环加成反应制备的。提供了生产方法、药物组合物和使用方法。
• [EN] ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS<br/>[FR] COMPOSÉS CIBLANT DES RÉCEPTEURS HORMONAUX NUCLÉAIRES ANTICANCÉREUX
  申请人：NUVATION BIO INC

  公开号：WO2019222272A1

  公开（公告）日：2019-11-21

  The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

  该披露涉及从核类固醇受体结合剂中衍生的抗癌化合物，以及含有这些化合物的产品，以及它们的使用和制备方法。
• Slow Self-Activation Enhances The Potency of Viridin Prodrugs
  作者：Joseph Blois、Hushan Yuan、Adam Smith、Michael E. Pacold、Ralph Weissleder、Lewis C. Cantley、Lee Josephson

  DOI：10.1021/jm800374f

  日期：2008.8.1

  When the viridin wortmannin (Wm) is modified by reaction with certain nucleophiles at the C20 position, the compounds obtained exhibit an improved antiproliferative activity even though a covalent reaction between C20 and a lysine in the active site of PI3 kinase is essential to Wm's ability to inhibit this enzyme. Here we show that this improved potency results from an intramolecular attack by the

  当 viridin wortmannin (Wm) 通过与 C20 位置的某些亲核试剂反应进行修饰时，即使 C20 与 PI3 激酶活性位点中的赖氨酸之间的共价反应对 Wm 的能力至关重要，但获得的化合物仍表现出改善的抗增殖活性。抑制这种酶。在这里，我们表明这种改进的效力是由 C6 羟基的分子内攻击导致的，该基团在抗增殖试验的 48 小时持续时间内将这些无活性的前药缓慢转化为活性物质 Wm。我们的结果为选择 Wm 样化合物提供了指导，以通过各种协议来最大限度地抑制激酶，这些协议用于评估 PI3 激酶在生物系统中的作用，或用于实现体内最佳治疗效果。此外，
• The preparation and properties of neutral diamide ionophores for group IIa metal cations
  作者：Irving J. Borowitz、Whei-Oh Lin、Tze-Chein Wun、Robert Bittman、Louis Weiss、Vladimir Diakiw、Grace B. Borowitz

  DOI：10.1016/0040-4020(77)84043-x

  日期：——

  featuring ether and N-methyl-N-carbethoxypentylamide groups is described. These ligands as well as related ones bearing other diamide groups are shown to selectively chelate Group IIA cations by picrate extraction from water to methylene chloride. The changes in UV absorption of aromatic rings and amide groups in the ligands upon titration with metal salts in methanol allow the estimation of the stoichiometry

  描述了一系列具有醚和N-甲基-N-碳乙氧基戊酰胺基团的中性配体的制备。这些配体以及带有其他二酰​​胺基团的相关配体显示出通过从水到二氯甲烷的苦味酸萃取选择性地螯合IIA组阳离子。用甲醇中的金属盐滴定后，配体中芳环和酰胺基团的紫外线吸收变化，可以估算络合的化学计量和阳离子结合的顺序。简要讨论了观察到的阳离子提取和结合的选择性序列。初步质子和13关于在甲醇中的一些配体上添加IIA族阳离子盐的影响的13 C NMR研究表明，大多数络合发生在中心醚和酰胺基上。通过反转恢复傅立叶变换法的13 C NMR T 1变化与阳离子诱导的位移数据一致。
• Wortmannin conjugates and uses thereof
  申请人：Yuan Hushan

  公开号：US20090324489A1

  公开（公告）日：2009-12-31

  The invention features conjugates of wortmannin, and wortmannin derivatives, and their use as inhibitors of PI3-kinase activity in treating cancer, inflammatory diseases, and C. albicans infections.

  本发明涉及沃特曼宁及其衍生物的共轭物，并将其用作PI3-激酶活性抑制剂，用于治疗癌症、炎症性疾病和C. albicans感染。