5-methoxy-2-(2,2,2-trifluoroacetyl)-1-indanone | 1373824-02-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 5-methoxy-2-(2,2,2-trifluoroacetyl)-1-indanone
• 英文别名: 5-Methoxy-2-(2,2,2-trifluoroacetyl)-2,3-dihydroinden-1-one；5-methoxy-2-(2,2,2-trifluoroacetyl)-2,3-dihydroinden-1-one
• CAS: 1373824-02-2
• 化学式: C₁₂H₉F₃O₃
• 分子量: 258.197
• InChiKey: ODPDXSNWOWYNQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-甲氧基-1-茚酮 、 三氟乙酸乙酯 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 14.5h， 以66%的产率得到5-methoxy-2-(2,2,2-trifluoroacetyl)-1-indanone
  参考文献：
  名称：

  [3+3] Cyclizations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes—a new approach to diverse CF3-substituted fluorenes, dibenzofurans, 9,10-dihydrophenanthrenes and 6H-benzo[c]chromenes

  摘要：

  Trifluoromethyl-substituted fluorenes, dibenzofurans, 9,10-dihydrophenanthrenes and 6H-benzo[c] chromenes were prepared by formal [3+3] cyclizations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes. The reactions proceeded with very good regioselectivity. The product distribution depends on the type of 1,3-dielectrophile employed and can be explained by electronic reasons. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.01.101

文献信息

• [3+3] Cyclizations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes—a new approach to diverse CF3-substituted fluorenes, dibenzofurans, 9,10-dihydrophenanthrenes and 6H-benzo[c]chromenes
  作者：Stefan Büttner、Nazken K. Kelzhanova、Zharylkasyn A. Abilov、Alexander Villinger、Peter Langer

  DOI：10.1016/j.tet.2012.01.101

  日期：2012.5

  Trifluoromethyl-substituted fluorenes, dibenzofurans, 9,10-dihydrophenanthrenes and 6H-benzo[c] chromenes were prepared by formal [3+3] cyclizations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes. The reactions proceeded with very good regioselectivity. The product distribution depends on the type of 1,3-dielectrophile employed and can be explained by electronic reasons. (C) 2012 Elsevier Ltd. All rights reserved.