1-(2-Chlorobenzyl)-1H-pyrrole-2,5-dione | 133517-61-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-Chlorobenzyl)-1H-pyrrole-2,5-dione
• 英文别名: 1-[(2-chlorophenyl)methyl]pyrrole-2,5-dione
• CAS: 133517-61-0
• 化学式: C₁₁H₈ClNO₂
• mdl: MFCD11149195
• 分子量: 221.643
• InChiKey: QVENOWGJIRIZAR-UHFFFAOYSA-N

物化性质

• 沸点：
  369.4±25.0 °C(Predicted)
• 密度：
  1.417±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-二甲基甲酰胺 、 1-(2-Chlorobenzyl)-1H-pyrrole-2,5-dione 在 potassium iodate 、 甲酸 、 copper(ll) sulfate pentahydrate 作用下， 以69 %的产率得到1-(2-chlorobenzyl)-3-(dimethylamino)-1H-pyrrole-2,5-dione
  参考文献：
  名称：

  在氧化剂 KIO3 存在下，铜催化马来酰亚胺和醌与甲酰胺的直接氧化胺化

  摘要：

  开发了一种在氧化剂 KIO 存在下铜催化马来酰亚胺和醌与甲酰胺直接胺化的简便、高效且实用的方法。它可以轻松获得各种功能化分子，并在药物和天然产物（如马来酰亚胺和醌）中具有特殊的支架。合成了多种取代的3-氨基马来酰亚胺和2-氨基醌，产率中等至优异。

  DOI：

  10.1016/j.tet.2024.133916
• 作为产物：
  描述：

  马来酸酐 、 邻氯苯甲胺 在 溶剂黄146 作用下， 生成 1-(2-Chlorobenzyl)-1H-pyrrole-2,5-dione
  参考文献：
  名称：

  在氧化剂 KIO3 存在下，铜催化马来酰亚胺和醌与甲酰胺的直接氧化胺化

  摘要：

  开发了一种在氧化剂 KIO 存在下铜催化马来酰亚胺和醌与甲酰胺直接胺化的简便、高效且实用的方法。它可以轻松获得各种功能化分子，并在药物和天然产物（如马来酰亚胺和醌）中具有特殊的支架。合成了多种取代的3-氨基马来酰亚胺和2-氨基醌，产率中等至优异。

  DOI：

  10.1016/j.tet.2024.133916

文献信息

• Bicyclic guanidine-catalyzed asymmetric Michael additions of 3-benzyl-substituted oxindoles to N-maleimides
  作者：Lixin Li、Wenchao Chen、Wenguo Yang、Yuanhang Pan、Hongjun Liu、Choon-Hong Tan、Zhiyong Jiang

  DOI：10.1039/c2cc31587d

  日期：——

  guanidine-catalyzed Michael addition of 3-benzyl substituted oxindoles to N-maleimides has been developed to produce oxindole derivatives with a quaternary carbon chiral center at the 3-position in excellent yields and enantio- and diastereoselectivities. This is the first incorporation of N-benzylic alpha-branched succinimides into 3,3-disubstituted oxindoles.

  已经开发了双苄基催化的3-苄基取代的羟吲哚到N-马来酰亚胺的迈克尔加成反应，以优异的收率和对映和非对映选择性生产具有季碳手性中心在3-位的羟吲哚衍生物。这是将N-苄基α-支化琥珀酰亚胺首次引入3,3-二取代的羟吲哚中。
• STYRENE RESIN COMPOSITION AND PROCESS FOR PRODUCING THE SAME
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP1026183A1

  公开（公告）日：2000-08-09

  A styrene resin composition excellent in luster, rigidity and surface impact strength is provided. A mixed solution of (b1) a homopolymer of a diene monomer or (b2) a copolymer of a styrene monomer and a diene monomer, the copolymer having 15% or less on a weight basis of the styrene structure units, (b3) a copolymer of a styrene monomer and a diene monomer, the copolymer having 20 to 50% on a weight basis of the styrene structure units, (a1) a styrene monomer, and (a2) a (meth)acrylic acid alkyl ester is continuously bulk polymerized in a continuous bulk polymerization line having incorporated therein a tubular reactor with a plurality of mixing elements that have no mobile part fixed inside thereof.

  本发明提供了一种在光泽、硬度和表面冲击强度方面都非常出色的苯乙烯树脂组合物。(b1)二烯单体的均聚物或(b2)苯乙烯单体和二烯单体的共聚物（共聚物中苯乙烯结构单元的重量比为 15%或以下）、(b3)苯乙烯单体和二烯单体的共聚物（共聚物中苯乙烯结构单元的重量比为 20%至 50%）的混合溶液、(a1) 苯乙烯单体和 (a2) (甲基)丙烯酸烷基酯在连续大体积聚合生产线中进行连续大体积聚合，该连续大体积聚合生产线包含一个管状反应器，该反应器具有多个混合元件，其内部没有固定的移动部件。
• Alkali-soluble maleimide copolymer and liquid crystal display comprising the same
  申请人：Tatsuzawa Masahiro

  公开号：US20050074563A1

  公开（公告）日：2005-04-07

  It is an object of the present invention to provide an alkali-soluble maleimide-based copolymer excellent in resistance for thermally yellowing, high in hardness, excellent in solubility in solvents and capable of readily forming uniform coat films and, in addition, capable of being satisfactorily dissolved in alkali water when remaining uncured, as well as a pigment dispersion composition comprising such copolymer and an ionizing radiation-curable resin composition comprising such copolymer. Another object of the present invention is to provide a color filter and a liquid crystal display which are formed by using the ionizing radiation-curable resin composition. The present invention is related to an alkali-soluble maleimide-based copolymer which comprises, as essential constituents, 5 to 50% by mass of a maleimide monomer unit which is at least one unit selected from the group consisting of a N-cyclohexylmaleimide monomer unit, a N-benzylmaleimide monomer unit and a substituted N-benzylmaleimide monomer unit, 8 to 30% by mass of the (meth)acrylic acid monomer unit and 30 to 87% by mass of a (meth)acrylic acid ester monomer unit and which satisfies the condition represented by the formula: 0.4×X≦Y≦0.5×X+10 where X is the content, in % by mass, of the N-cyclohexylmaleimide monomer unit, the N-benzylmaleimide monomer unit and the substituted N-benzylmaleimide monomer unit and Y is the content, in % by mass, of the (meth)acrylic acid monomer unit.

  本发明的目的是提供一种碱溶性马来酰亚胺基共聚物，该共聚物具有优异的耐热黄变性、高硬度、优异的溶剂溶解性和易于形成均匀涂膜的性能，此外，在未固化时能够令人满意地溶解于碱水中，本发明还提供一种包含这种共聚物的颜料分散组合物和一种包含这种共聚物的电离辐射固化树脂组合物。本发明的另一个目的是提供使用电离辐射固化树脂组合物形成的彩色滤光片和液晶显示器。本发明涉及一种碱溶性马来酰亚胺基共聚物，其基本成分包括 5-50%（质量）的马来酰亚胺单体单元，马来酰亚胺单体单元至少是选自以下组别的一个单元： N-环己基马来酰亚胺单体单元、N-苄基马来酰亚胺单体单元和取代的 N-苄基马来酰亚胺单体单元组成的组中的至少一种单元；8%至 30%（质量分数）的（甲基）丙烯酸单体单元和 30%至 87%（质量分数）的（甲基）丙烯酸酯单体单元，且满足由式表示的条件： 0.4×x≦y≦0.5×x+10 其中，X 为 N-环己基马来酰亚胺单体单元、N-苄基马来酰亚胺单体单元和取代的 N-苄基马来酰亚胺单体单元的含量（质量百分比），Y 为（甲基）丙烯酸单体单元的含量（质量百分比）。
• [EN] ALKALI-SOLUBLE MALEIMIDE COPOLYMER AND LIQUID CRYSTAL DISPLAY COMPRISING THE SAME<br/>[FR] COPOLYMERE DE MALEIMIDE SOLUBLE ALCALIN ET ECRAN A CRISTAUX LIQUIDES CONTENANT CE COPOLYMERE
  申请人：DAINIPPON PRINTING CO LTD

  公开号：WO2003027156A1

  公开（公告）日：2003-04-03

  It is an object of the present invention to provide an alkali-soluble maleimide-based copolymer excellent in resistance for thermally yellowing, high in hardness, excellent in solubility in solvents and capable of readily forming uniform coat films and, in addition, capable of being satisfactorily dissolved in alkali water when remaining uncured, as well as a pigment dispersion composition comprising such copolymer and an ionizing radiation-curable resin composition comprising such copolymer. Another object of the present invention is to provide a color filter and a liquid crystal display which are formed by using the ionizing radiation-curable resin composition. The present invention is related to an alkali-soluble maleimide-based copolymer which comprises, as essential constituents, 5 to 50% by mass of a maleimide monomer unit which is at least one unit selected from the group consisting of a N-cyclohexylmaleimide monomer unit, a N-benzylmaleimide monomer unit and a substituted N-benzylmaleimide monomer unit, 8 to 30% by mass of the (meth)acrylic acid monomer unit and 30 to 87% by mass of a (meth)acrylic acid ester monomer unit and which satisfies the condition represented by the formula: 0.4 X Y 0.5 X + 10 where X is the content, in % by mass, of the N-cyclohexylmaleimide monomer unit, the N-benzylmaleimide monomer unit and the substituted N-benzylmaleimide monomer unit and Y is the content, in % by mass, of the (meth)acrylic acid monomer unit.

  本发明的目的是提供一种耐热黄变性优异、硬度高、在溶剂中溶解性良好，并且能够轻易形成均匀涂膜的碱溶性马来酰亚胺基共聚物，以及一种包含此类共聚物的色料分散组合物和一种包含此类共聚物的离子辐射固化树脂组合物。本发明的另一个目的是提供一种使用所述离子辐射固化树脂组合物制成的色阻滤光片和液晶显示器。本发明涉及一种包含以下主要成分的碱溶性马来酰亚胺基共聚物：5%至50%质量百分含量的马来酰亚胺单体单元，所述马来酰亚胺单体单元选自以下至少一种：N-环己基马来酰亚胺单体单元、N-苄基马来酰亚胺单体单元和取代的N-苄基马来酰亚胺单体单元；8%至30%质量百分含量的（甲基）丙烯酸单体单元；以及30%至87%质量百分含量的（甲基）丙烯酸酯单体单元。并且，该共聚物满足以下公式表示的条件：0.4 ≤ X / Y ≤ 0.5X + 10，其中X为N-环己基马来酰亚胺单体单元、N-苄基马来酰亚胺单体单元和取代的N-苄基马来酰亚胺单体单元的质量百分含量之和，Y为（甲基）丙烯酸单体单元的质量百分含量。
• Organocatalytic enantioselective synthesis of N-alkyl/aryl-3-alkyl-pyrrolidine-2,5-dione in brine
  作者：Suhel Mahajan、Pankaj Chauhan、Akshay Kumar、Swapandeep Singh Chimni

  DOI：10.1016/j.tetasy.2016.09.004

  日期：2016.12

  A highly enantioselective approach has been developed for synthesising chiral succinimide derivatives via asymmetric Michael addition of diketones to maleimide using dihydroquinine as a catalyst in brine. The Michael adducts were obtained in yields up to 98% and with enantiomeric excesses up to 98% ee. (C) 2016 Elsevier Ltd. All rights reserved.