benzoic 4-chlorobenzoic anhydride | 21961-55-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzoic 4-chlorobenzoic anhydride
• 英文别名: Benzoyl 4-chlorobenzoate
• CAS: 21961-55-7
• 化学式: C₁₄H₉ClO₃
• 分子量: 260.677
• InChiKey: YLSUXJGOPMIUBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzoic 4-chlorobenzoic anhydride 、 异丙醇 在 [Cp(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)Ru(pyridine)₂][PF₆] 、 potassium tert-butylate 作用下， 反应 4.0h， 生成 异丙基4-氯苯甲酸酯
  参考文献：
  名称：

  N-杂环卡宾负载的钌半三明治络合物催化的腈，烯烃和N-杂环的转移加氢

  摘要：

  In the presence of KOBut, N-heterocyclic carbene-supported half-sandwich complex [Cp(IPr)Ru(pyr)(2)][PF6] (3) (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2ylidene) catalyzes transfer hydrogenation (TH) of nitriles, activated N-heterocycles, olefins, and conjugated olefins in isopropanol at the catalyst loading of 0.5%. The TH of nitriles leads to imines, produced as a result of coupling of the initially formed amines with acetone (produced from isopropanol), and showed good chemoselectivity. Reduction of N-heterocycles occurs for activated polycyclic substrates (e.g., quinoline) and takes place exclusively in the heterocycle. The TH also works well for linear and cyclic olefins but fails for trisubstituted substrates. However, the C=C bond of alpha,beta-unsaturated esters, amides, and acids is easily reduced even for trisubstituted species, such as isovaleriates. Mechanistic studies suggest that the active species in these catalytic reactions is the trihydride Cp(IPr)RuH3 (5), which can catalyze these reactions in the absence of any base. Kinetic studies are consistent with a classical inner sphere hydride-based mechanism of TH.

  DOI：

  10.1021/acs.organomet.5b00967
• 作为产物：
  描述：

  苯甲酸苄酯 在 iron(III) chloride 、 二氯二苯甲烷 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 benzoic 4-chlorobenzoic anhydride
  参考文献：
  名称：

  在温和条件下使用催化氯化铁 (III) 将苄基酯直接转化为酯、酰胺和酸酐

  摘要：

  描述了一种将苄酯轻松一锅转化为酯、酰胺和酸酐的方法。采用α,α-二氯二苯甲烷和FeCl 3分别作为氯化剂和催化剂，将苄酯转化为酰氯中间体，直接与醇、胺、羧酸反应。在温和的条件下很容易以高产率获得各种酯、酰胺和酸酐。该方法有望用于从苄酯实际合成酯、酰胺和酸酐。

  DOI：

  10.1039/d3ob01443f

文献信息

• Iron-Doped Single-Walled Carbon Nanotubes as New Heterogeneous and Highly Efficient Catalyst for Acylation of Alcohols, Phenols, Carboxylic Acids and Amines under Solvent-Free Conditions
  作者：Hashem Sharghi、Mahboubeh Jokar、Mohammad Mahdi Doroodmand

  DOI：10.1002/adsc.201000365

  日期：2011.2.11

  single-walled carbon nanotubes (Fe/SWCNTs) represent an efficient and new heterogeneous reusable catalyst for the acylation of a variety of alcohols, phenols, carboxylic acids and amines with acid chlorides or acid anhydrides under solvent-free conditions. The reactions of various primary, secondary, tertiary, and benzylic alcohols, diols, phenols, as well as aromatic and aliphatic amines give acylated

  掺杂铁的单壁碳纳米管（Fe / SWCNT）代表了一种高效且新型的多相可重复使用的催化剂，用于在无溶剂条件下将各种醇，酚，羧酸和胺与酰氯或酸酐酰化。各种伯，仲，叔和苯甲醇，二醇，苯酚以及芳族和脂族胺的反应均以极好的收率得到了酰化的加合物。
• [EN] PROCESS FOR THE PRODUCTION OF DIACYL PEROXIDES<br/>[FR] PROCÉDÉ DE PRODUCTION DE PEROXYDES DE DIACYLE
  申请人：NOURYON CHEMICALS INT BV

  公开号：WO2020249688A1

  公开（公告）日：2020-12-17

  Process for the production of a diacyl peroxide involving the reaction of an anhydride with hydrogen peroxide, removal of the formed carboxylic acid, production of an anhydride from said carboxylic acid, and recycling of the anhydride within the process.

  生产二酰过氧化物的过程涉及酐与过氧化氢的反应，去除形成的羧酸，从所述羧酸生产酐，并在过程中循环使用酐。
• AN EFFICIENT AND SIMPLE PROCEDURE FOR PREPARATION OF ESTERS AND ANHYDRIDES FROM ACID CHLORIDES IN THE PRESENCE OF 1,4-DIAZABICYCLO[2.2.2]OCTANE (DABCO) UNDER SOLVENT-FREE CONDITIONS
  作者：A. R. Hajipour、Gh. Mazloumi

  DOI：10.1081/scc-120001504

  日期：2002.1.1

  one-pot and rapid method for the synthesis of aliphatic and aromatic ester and anhydride from acid chloride and alcohol or potassium salt of carboxylic acid under solvent-free conditions is reported. The reaction has been carried out in excellent yield and short reaction time in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) under solvent-free conditions.

  摘要报道了一种在无溶剂条件下从酰氯和羧酸的醇或钾盐合成脂肪族和芳香族酯和酸酐的可操作的一锅法和快速方法。该反应在 1,4-二氮杂双环 [2.2.2] 辛烷 (DABCO) 的存在下，在无溶剂条件下以优异的收率和较短的反应时间进行。
• Anhydrides from aldehydes or alcohols via oxidative cross-coupling
  作者：Silvia Gaspa、Ida Amura、Andrea Porcheddu、Lidia De Luca

  DOI：10.1039/c6nj02625g

  日期：——

  A novel type of metal-free oxidative cross-coupling for the synthesis of symmetrical and mixed anhydrides from aldehydes or benzylic alcohols has been developed. The aldehydes or alcohols were converted in situ into their corresponding acyl chlorides, which were then reacted with an array of carboxylic acids. The methodology has a general applicability, and was successfully employed to prepare either

  已经开发了一种新型的无金属氧化交叉偶联反应，用于从醛或苯甲醇合成对称和混合酸酐。将醛或醇原位转化为其相应的酰氯，然后使其与一系列羧酸反应。该方法具有普遍适用性，已成功用于制备非常不稳定的芳族或脂族对称酸酐和混合酸酐。
• [EN] COMPOUNDS AND METHODS FOR TREATING ESTROGEN RECEPTOR-RELATED DISEASES<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR TRAITER DES MALADIES LIÉES À UN RÉCEPTEUR D'OETROGÈNE
  申请人：SHENOGEN PHARMA GROUP LTD

  公开号：WO2009129372A1

  公开（公告）日：2009-10-22

  Provided herein in certain embodiments are compounds, pharmaceutical compositions and methods for modulating the functions of estrogen receptor alpha 36, for preventing and/or treating diseases mediated by estrogen receptor alpha 36, for preventing and/or treating osteoporosis, for inducing cell death and/or inhibiting cell proliferation and for preventing and/or treating diseases involving abnormal cell proliferation such as cancers.

  在某些实施例中提供了化合物、药物组合物和方法，用于调节雌激素受体α36的功能，用于预防和/或治疗由雌激素受体α36介导的疾病，用于预防和/或治疗骨质疏松症，用于诱导细胞死亡和/或抑制细胞增殖，以及用于预防和/或治疗涉及异常细胞增殖的疾病，如癌症。